Faculty profile

Michael Hendzel

ResearcherOncologyUniversity of Alberta

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Alberta directory, so their courses and email address may be missing. Find their university profile.

Michael Hendzel

Researcher

Oncology

Health Sciences

University of Alberta

Edmonton, Alberta, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
1 publication in the last five years, latest in 2026.
Principal investigator on 5 research grants (4 CIHR, 1 NSERC), most recently in 2021.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Publications

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Chromatin Crc 53bp1 Brca1 Dna Double-Strand Break Repair Dna End Resection Electron Microscopy Histone

Latest papers

MeCP2 NID interaction with RNA: implications for Rett syndrome-relevant protein regulation.
Human molecular genetics · 2026
Polycomb group-mediated histone H2A monoubiquitination in epigenome regulation and nuclear processes.
Nature communications · 2020
The Interchromatin Compartment Participates in the Structural and Functional Organization of the Cell Nucleus.
BioEssays : news and reviews in molecular, cellular and developmental biology · 2020

All 7 publications

Latest funding

Determinants of chromatin rigidity during cancer cell invasion and migration
CIHR · 2023 · Co-investigator
$62,500
Canada Research Chair - Tier 1
CIHR · 2021 · Nominated PI
$1,400,000
Role of BRCT proteins in DNA damage signaling
CIHR · 2019 · Co-investigator
$826,200

All 12 grants and awards

7 publications.

MeCP2 NID interaction with RNA: implications for Rett syndrome-relevant protein regulation.

Good KV, Strickfaden H, Muhammad T, Vincent JB, Hendzel M, Nelson CJ, Ausió J

Human molecular genetics2026

DOI: 10.1093/hmg/ddag031 PMID: 42051147

Polycomb group-mediated histone H2A monoubiquitination in epigenome regulation and nuclear processes.

Barbour H, Daou S, Hendzel M, Affar EB

Nature communications2020

DOI: 10.1038/s41467-020-19722-9 PMID: 33230107

The Interchromatin Compartment Participates in the Structural and Functional Organization of the Cell Nucleus.

Cremer T, Cremer M, Hübner B, Silahtaroglu A, Hendzel M, Lanctôt C, Strickfaden H, Cremer C

BioEssays : news and reviews in molecular, cellular and developmental biology2020

DOI: 10.1002/bies.201900132 PMID: 31994771

Trichostatin A decreases the levels of MeCP2 expression and phosphorylation and increases its chromatin binding affinity.

Good KV, Martínez de Paz A, Tyagi M, Cheema MS, Thambirajah AA, Gretzinger TL, Stefanelli G, Chow RL, Krupke O, Hendzel M, Missiaen K, Underhill A, Landsberger N, Ausió J

Epigenetics2017

DOI: 10.1080/15592294.2017.1380760 PMID: 29099289

Interaction of chromatin with a histone H1 containing swapped N- and C-terminal domains.

Hutchinson JB, Cheema MS, Wang J, Missiaen K, Finn R, Gonzalez Romero R, Th'ng JP, Hendzel M, Ausió J

Bioscience reports2015

DOI: 10.1042/bsr20150087 PMID: 26182371

Improved transfection efficiency of an aliphatic lipid substituted 2 kDa polyethylenimine is attributed to enhanced nuclear association and uptake in rat bone marrow stromal cell.

Hsu CY, Hendzel M, Uludaǧ H

The journal of gene medicine2011

DOI: 10.1002/jgm.1526 PMID: 21259408

Modeling transcription factor binding events to DNA using a random walker/jumper representation on a 1D/2D lattice with different affinity sites.

Rezania V, Tuszynski J, Hendzel M

Physical biology2007Senior author

DOI: 10.1088/1478-3975/4/4/003 PMID: 18185004

Determinants of chromatin rigidity during cancer cell invasion and migration

Co-investigatorCIHR2023CIHR - ICR / Cancer Research Society Partnership - Res. Grants - Breast Cancer

Principal investigators: Underhill, D. A

Keywords: Imaging Technologies; Oncogenes And Tumour Suppressors ; Tumour Progression And Metastasis

$62,500

Canada Research Chair - Tier 1

Nominated PICIHR2021Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Hendzel, Michael J

Keywords: Crc

$1,400,000

Role of BRCT proteins in DNA damage signaling

Co-investigatorCIHR2019Project Grant

Principal investigators: Glover, J. N. Mark

Keywords: Brct Proteins; Dna Damage Signaling; Mcph1; Mdc1; Mrna Display; Nucleosome Structure; Phosphoprotein Signaling; Small Angle X-Ray Scattering; Structural Biology; X-Ray Crystallography

$826,200

Structure-function relationships at DNA double-strand break repair centers

Nominated PICIHR2018Project Grant

Principal investigators: Hendzel, Michael J

Keywords: 53bp1; Brca1; Chromatin; Dna Double-Strand Break Repair; Dna End Resection; Electron Microscopy; Histone; Homologous Recombination; Ir-Induced Foci; Nonhomologous End Joining

$837,675

Role of BRCT proteins in DNA damage signaling

Co-investigatorCIHR2018Project Grant

Principal investigators: Glover, J. N. Mark

Keywords: Brct Proteins; Dna Damage Signaling; Mdc1; Mrna Display; Nucleosome Structure; Phosphoprotein Signaling; Small Angle X-Ray Scattering; Structural Biology; Topbp1; X-Ray Crystallography

$100,000

Alberta Epigenetics Network Research Summit

Principal investigatorNSERC2017Connect Grants Level 2

Principal investigators: Hendzel, Michael

$5,000

Studying the role of DNA damage induced RNA in the molecular mechanisms promoting homologous recombination in mammalian cells

Nominated PICIHR2016Project Grant

Principal investigators: Hendzel, Michael J

Keywords: Argonaut Proteins; Chromatin; Dgcr8; Dna Damage Signaling; Dna Double-Strand Break; Drosha; Heterochromatin; Histone Methylation; Hp1; Rna Interference

$749,211

Development of inhibitors of Ubc13 and USP7 and assessment of their impact on cancer cell signaling

Co-investigatorCIHR2016Project Grant

Principal investigators: Glover, J. N. Mark

Keywords: Dna Damage Signaling,; Lys63 Polyubiquitination; Nf-Kb Signaling; Protein Ubiquitination; Rational Drug Design; Structural Biology; Ubc13; Usp7; X-Ray Crystallography

$100,000

Dissecting the signalling functions of polycomb-mediated ubiquitylation in DNA double-strand break repair

Nominated PICIHR2011Operating Grant

Principal investigators: Hendzel, Michael J

Keywords: Bap1; Cancer Stem Cell; Chromatin; Dna Double-Strand Breaks; Polycomb; Radiation Therapy; Ubiquitylation

$768,687

Mathematics of Information Technology and Complex Systems/Les mathématiques des technologies de l'information et des systèmes complexes

Co-investigatorNSERC2009Networks of Centres of Excellence

Principal investigators: Gupta, Arvind

$12,553,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Michael Hendzel

Research

Latest papers

Latest funding

MeCP2 NID interaction with RNA: implications for Rett syndrome-relevant protein regulation.

Polycomb group-mediated histone H2A monoubiquitination in epigenome regulation and nuclear processes.

The Interchromatin Compartment Participates in the Structural and Functional Organization of the Cell Nucleus.

Trichostatin A decreases the levels of MeCP2 expression and phosphorylation and increases its chromatin binding affinity.

Interaction of chromatin with a histone H1 containing swapped N- and C-terminal domains.

Improved transfection efficiency of an aliphatic lipid substituted 2 kDa polyethylenimine is attributed to enhanced nuclear association and uptake in rat bone marrow stromal cell.

Modeling transcription factor binding events to DNA using a random walker/jumper representation on a 1D/2D lattice with different affinity sites.

Determinants of chromatin rigidity during cancer cell invasion and migration

Canada Research Chair - Tier 1

Role of BRCT proteins in DNA damage signaling

Structure-function relationships at DNA double-strand break repair centers

Role of BRCT proteins in DNA damage signaling

Alberta Epigenetics Network Research Summit

Studying the role of DNA damage induced RNA in the molecular mechanisms promoting homologous recombination in mammalian cells

Development of inhibitors of Ubc13 and USP7 and assessment of their impact on cancer cell signaling

Dissecting the signalling functions of polycomb-mediated ubiquitylation in DNA double-strand break repair

Mathematics of Information Technology and Complex Systems/Les mathématiques des technologies de l'information et des systèmes complexes

Frequent collaborators

Jack Tuszynski