Michael James, University of Alberta

Research

Inhibitor Design For The Papain-Like Enzyme Form Covid-19 Enzyme Enchancement Therapy Lysosomal Storage Disease Mucopolysaccharidosis Type I Neurodegenerative Disease Structural Biology

Latest papers

The Ubiquitination of PINK1 Is Restricted to Its Mature 52-kDa Form.
Cell reports · 2017

All 1 publications

Latest funding

COVID-19 Variant Supplement - Towards anti-COVID-19 therapeutic development by targeting the viral papain-like proteinase
CIHR · 2021 · Nominated PI
$50,000
Towards anti-COVID-19 therapeutic development by targeting the viral papain-like proteinase
CIHR · 2020 · Nominated PI
$248,800
Mucopolysaccharidosis I Disease: Tools for Discovery and Design of Chaperone Therapeutics Based on Unique Enzyme Production Systems and the Elucidation of the Structure of alpha-L-Iduronidase
CIHR · 2012 · Nominated PI
$387,633

All 7 grants and awards

1 publications.

01

The Ubiquitination of PINK1 Is Restricted to Its Mature 52-kDa Form.

Liu Y, Guardia-Laguarta C, Yin J, Erdjument-Bromage H, Martin B, James M, Jiang X, Przedborski S

Cell reports2017

DOI: 10.1016/j.celrep.2017.06.022 PMID: 28683321

COVID-19 Variant Supplement - Towards anti-COVID-19 therapeutic development by targeting the viral papain-like proteinase

Nominated PICIHR2021Operating Grant: SARS-CoV-2 variants supplement stream 1

Principal investigators: James, Michael N

Keywords: Inhibitor Design For The Papain-Like Enzyme Form Covid-19

$50,000

Towards anti-COVID-19 therapeutic development by targeting the viral papain-like proteinase

Nominated PICIHR2020Operating Grant: COVID-19 - Therapeutics

Principal investigators: James, Michael N

Keywords: Inhibitor Design For The Papain-Like Enzyme Form Covid-19

$248,800

Mucopolysaccharidosis I Disease: Tools for Discovery and Design of Chaperone Therapeutics Based on Unique Enzyme Production Systems and the Elucidation of the Structure of alpha-L-Iduronidase

Nominated PICIHR2012Operating Grant

Principal investigators: James, Michael N

Keywords: Enzyme Enchancement Therapy; Lysosomal Storage Disease; Mucopolysaccharidosis Type I; Neurodegenerative Disease; Structural Biology

$387,633

X-ray crystal structure analysis of phosphoglycerate kinase from gram-negative pathogens: validation of an anti-microbial drug target

Principal investigatorNSERC2011Collaborative Research and Development Grants

Principal investigators: James, Michael

$67,700

Validation of antimicrobial drug target selection using X-ray crystallographic methods

Principal investigatorNSERC2010Engage Grants Program

Principal investigators: James, Michael

$25,000

Protein Engineering Network of Centres of Excellence (PENCE)

Co-investigatorNSERC1997Networks of Centres of Excellence

Principal investigators: Hodges, Robert

$16,362,500

Development of inhibitors of Picornaviral 3C proteinases

Principal investigatorNSERC1994Collaborative Project Grants (H)

Principal investigators: James, Michael

$255,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Write to this professor

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Applying for

Mention their CIHR grant from 2021

Subject: Prospective PhD student: Inhibitor Design For The Papain-Like Enzyme Form Covid-19 Dear Professor James, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "The Ubiquitination of PINK1 Is Restricted to Its Mature 52-kDa Form." (2017), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "COVID-19 Variant Supplement - Towards anti-COVID-19 therapeutic development by targeting the viral papain-like proteinase" (2021), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]