Michael Woodside

Developing single-molecule mass photometry as a tool for discovering and characterising protein aggregation inhibitors

Principal investigators: Woodside, Michael MT

Keywords: antibodies; drug discovery; kinetic modeling; light scattering; mass photometry; neurodegenerative disease; peptide inhibitors; protein aggregation; single-molecule biophysics; small-molecule inhibitors

Using engineered heterodimers to probe prion-like propagation of misfolding in SOD1

Principal investigators: Woodside, Michael T

Keywords: Amyotrophic Lateral Sclerosis (Als); Enzymatic Activity; Fluorescence Spectroscopy And Microscopy Of Aggregation; Misfolding Inhibitors; Pathogenic Mutations; Prion-Like Conversion; Protein Misfolding; Sandwich Elisa; Single-Molecule Force Spectroscopy; Superoxide Dismutase-1

Probing the role of mechanical rigidity in viral xrRNAs as the key to preventing their degradation by host RNases

Principal investigators: Woodside, Michael T

Keywords: Exoribonuclease-Resistant Rnas; Flaviviruses; Mechanical Resistance; Mutagenesis; Rna Folding; Rna Knots; Rnase Dynamics; Single-Molecule Force Spectroscopy; Subgenomic Rnas; Viral Pathogenicity

COVID-19 Variant Supplement - Targeting programmed ribosomal frameshifting as a therapeutic strategy against 2019-nCoV

Principal investigators: Woodside, Michael T; Tuszynski, Jack A

Keywords: Computational Ligand Docking; Coronavirus; Force Spectroscopy; High-Throughput In Silico Screening; Programmed Ribosomal Frameshifting; Rna Pseudoknot; Rna Structure; Rna-Ligand Binding; Structural Modeling

Single-molecule mass photometry to probe the competition between protein aggregation and native folding

Principal investigators: Woodside, Michael

Probing the conformational dynamics of the frameshift-stimulatory pseudoknot of SARS-CoV-2 at the single-molecule level.

Principal investigators: Munshi, Sneha

Keywords: -1 Programmed Frameshift In Virus; Binding Studies- Surface Plasmon Resonance; Enzymatic Assay; Single Molecule Studies - Optical Tweezers

Targeting programmed ribosomal frameshifting as a therapeutic strategy against 2019-nCoV

Principal investigators: Woodside, Michael T; Tuszynski, Jack A

Keywords: Computational Ligand Docking; Coronavirus; Force Spectroscopy; High-Throughput In Silico Screening; Programmed Ribosomal Frameshifting; Rna Pseudoknot; Rna Structure; Rna-Ligand Binding; Structural Modeling

Towards more effective therapeutics for neurodegeneration by understanding the mechanisms of prion strain adaptation

Principal investigators: Woodside, Michael

Keywords: protein folding and misfolding; neurodegeneration; prion strains; glycoproteins; single-molecule biophysics; chemical synthesis; force spectroscopy; prion propagation; post-translational modifications

Direct measurements of transition paths in the folding of single biomolecules using force spectroscopy

Principal investigators: Woodside, Michael

Understanding how incorrect structures form and propagate in the protein SOD1 linked ALS

Principal investigators: Scholl, Zackary N

Keywords: Als; Protein Folding; Sod1