This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Alberta directory, so their courses may be missing. Find their university profile.
Latest papers
Scale up manufacturing approach for production of human induced pluripotent stem cell-derived islets using Vertical Wheel® bioreactors.
NPJ Regenerative medicine · 2025
Reduced Expression of the Co-regulator TLE1 in Type 2 Diabetes Is Associated with Increased Islet α-Cell Number.
Endocrinology · 2020
Control of secretory granule access to the plasma membrane by PI3 kinase-γ.
Islets · 2009 · first author
Latest funding
- $6,000
Cytokine-induced protein translocation to the plasma membrane in human pancreatic islets
CIHR · 2026 · Supervisor
- $140,000
Defining the Role of Selective mRNA Export in Pancreatic Islet Physiology and Diabetes Pathophysiology
CIHR · 2025 · Supervisor
- $872,100
Cellular mechanisms tuning insulin secretion to meet metabolic demand
CIHR · 2024 · Nominated PI
3 publications.
Scale up manufacturing approach for production of human induced pluripotent stem cell-derived islets using Vertical Wheel® bioreactors.
Dadheech N, Bermúdez de León M, Czarnecka Z, Cuesta-Gomez N, Jasra IT, Pawlick R, Marfil-Garza B, Sapkota S, Verhoeff K, Razavy H, Anwar P, Singh A, Ray N, O' Gorman D, Jickling G, Lyon J, MacDonald P, Shapiro AMJ
Reduced Expression of the Co-regulator TLE1 in Type 2 Diabetes Is Associated with Increased Islet α-Cell Number.
Armour SL, Anderson SJ, Richardson SJ, Ding Y, Carey C, Lyon J, Maheshwari RR, Al-Jahdami N, Krasnogor N, Morgan NG, MacDonald P, Shaw JAM, White MG
Control of secretory granule access to the plasma membrane by PI3 kinase-γ.
MacDonald P
Cytokine-induced protein translocation to the plasma membrane in human pancreatic islets
Principal investigators: Abifarin, Oluwatodimu
Keywords: Cellular Stress; Immune Attack; Insulin-Producing Pancreatic Beta-Cells; Type 1 Diabetes
Defining the Role of Selective mRNA Export in Pancreatic Islet Physiology and Diabetes Pathophysiology
Principal investigators: dos Santos, Theodore
Keywords: Diabetes; Glucagon Secretion; Insulin Secretion; Molecular Mechanisms Of Disease; Mrna Export; Multi-Omics; Pancreatic Islets; Post-Transcriptional Regulation; Single-Cell Proteomics; Single-Nucleus Rna Sequencing
Cellular mechanisms tuning insulin secretion to meet metabolic demand
Principal investigators: MacDonald, Patrick E
Keywords: Diabetes; Electrophysiology; Human; Insulin; Islets Of Langerhans; Redox; Secretion
Dysfunctional and Resistant Islet Cell Populations in Human Diabetes
Principal investigators: MacDonald, Patrick E
Keywords: Biobanking; Diabetes; Electrophysiology; Genomics; Glucagon; Human Tissue; Insulin; Islets Of Langerhans; Single-Cell
A First-in-human Trial of Autologous Induced Pluripotent Stem Cells (iPSC)-Derived Islets: Developing a Personalized Diabetes Therapy
Principal investigators: Shapiro, James; Kieffer, Timothy J; Korbutt, Gregory S; MacDonald, Patrick E; Pepper, Andrew R
Keywords: Autoimmunity; Autologous Human Ipscs; Beta Cell Replacement Therapy; Cell Replacement Therapy; Clinical Trial; Diabetes Treatment; Induced Pluripotent Stem Cells; Islet Transplantation; Personalized Cell Therapy; Stem Cell Biology
A deep phenotyping network for understanding human islet variation in health and diabetes
Principal investigators: MacDonald, Patrick E; Bruin, Jennifer E; Johnson, James D; Xia, Jianguo
Keywords: Biobanking; Diabetes; Electrophysiology; Environmental Contaminants; Genetic Risk; Genomics; Islets Of Langerhans; Metabolomics; Proteomics; Resources
A deep phenotyping network for understanding human islet variation in health and diabetes
Principal investigators: MacDonald, Patrick E; Bruin, Jennifer E; Johnson, James D; Xia, Jianguo
Keywords: Biobanking; Diabetes; Environmental Toxicology; Genetics; Genomics; Insulin; Islets Of Langerhans; Metabolomics; Pancreas; Proteomics
A First-in-human Trial of Autologous Induced Pluripotent Stem Cell (iPSC)-Derived Islets: Developing a Personalized Diabetes Therapy
Principal investigators: Shapiro, James; Kieffer, Timothy J; Korbutt, Gregory S; MacDonald, Patrick E; Pepper, Andrew R
Keywords: Beta Cell Replacement Therapy; Induced Pluripotent Stem Cells; Treatment For Diabetes
Canada Research Chairs - Tier 1
Principal investigators: MacDonald, Patrick E
Keywords: Crc
Mechanisms controlling the magnitude of insulin secretory responses and their role in type 2 diabetes
Principal investigators: MacDonald, Patrick E
Keywords: Biobank; Diabetes; Electrophysiology; Exocytosis; Human; Insulin; Islets Of Langerhans; Metabolism; Signalling; Sumoylation
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
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