Jennifer Cobb, University of Calgary

Research

Dna Repair Molecular Biology Genetics Genome Stability Aging Cancer Genome Integrity S. Cerevisiae (Budding Yeast)

Latest papers

Intrinsic disorder of a nucleoplasmin-like histone chaperone specifies its discrete nuclear and nucleolar functions.
FEBS letters · 2024
The NuA4 complex promotes translesion synthesis (TLS)-mediated DNA damage tolerance.
Genetics · 2015 · senior author
Mapping genomic targets of DNA helicases by chromatin immunoprecipitation in Saccharomyces cerevisiae.
Methods in molecular biology (Clifton, N.J.) · 2010 · first author

All 3 publications

Latest funding

Oxygen-Regulated Tissue Culturing for Accurate In Virto Cell Analyses
NSERC · 2022 · Co-investigator
$150,000
The role of Nej1 in DSB repair pathway choice and MMEJ
CIHR · 2020 · Nominated PI
$785,075
Characterization of Dyskerin in DNA double-strand break repair
CIHR · 2020 · Nominated PI
$845,792

All 10 grants and awards

3 publications.

01

Intrinsic disorder of a nucleoplasmin-like histone chaperone specifies its discrete nuclear and nucleolar functions.

Gauthier CM, LeGallais J, Savic N, Moradi-Fard S, Grew A, Loe M, Kirlikaya B, Cobb J, Nelson CJ

FEBS letters2024

DOI: 10.1002/1873-3468.14783 PMID: 38058218

02

The NuA4 complex promotes translesion synthesis (TLS)-mediated DNA damage tolerance.

Renaud-Young M, Lloyd DC, Chatfield-Reed K, George I, Chua G, Cobb J

Genetics2015Senior author

DOI: 10.1534/genetics.115.174490 PMID: 25701288

03

Mapping genomic targets of DNA helicases by chromatin immunoprecipitation in Saccharomyces cerevisiae.

Cobb J, van Attikum H

Methods in molecular biology (Clifton, N.J.)2010First author

DOI: 10.1007/978-1-60327-355-8_8 PMID: 20225145

Oxygen-Regulated Tissue Culturing for Accurate In Virto Cell Analyses

Co-investigatorNSERC2022Research Tools and Instruments

Principal investigators: Riabowol, Karl

$150,000

The role of Nej1 in DSB repair pathway choice and MMEJ

Nominated PICIHR2020Project Grant

Principal investigators: Cobb, Jennifer A

Keywords: Dna Repair; Genome Stability; Molecular Biology; S. Cerevisiae (Budding Yeast)

$785,075

Characterization of Dyskerin in DNA double-strand break repair

Nominated PICIHR2020Project Grant

Principal investigators: Cobb, Jennifer A

Keywords: Dna Repair; Genetics; Genome Stability; Molecular Biology

$845,792

Characterizing RecQ helicase Sgs1 in maintaining genomic stability during aging

Nominated PICIHR2017Project Grant

Principal investigators: Cobb, Jennifer A

Keywords: Aging; Dna Damage; Dna Repair; Dna Replication; Genomic Stability; Recq Helicase; Sgs1; Yeast

$979,200

The role of the Smc5/6 complex in nuclear organization

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Cobb, Jennifer

$200,000

3rd Canadian Symposium on Telomeres and Genomic Integrity

Nominated PICIHR2015Planning and Dissemination Grant - Institute Community Support

Principal investigators: Cobb, Jennifer A

Keywords: Aging; Cancer; Genome Integrity; Telomeres

$10,000

Nej1 and Lif1 form structural filaments that bridge the ends of DNA at a DSB

Nominated PICIHR2014Operating Grant

Principal investigators: Cobb, Jennifer A

Keywords: Cancer; Dna Repair; Genetics; Genome Integrity; Genomic Rearrangements; Molecular Biology

$628,466

The role of the Smc5/6 complex in DNA repair

Principal investigatorNSERC2012Discovery Grants Program - Individual

Principal investigators: Cobb, Jennifer

$140,000

Mre11/Rad50/Xrs2 regulates the cohesin complex at sites of replication stress

Nominated PICIHR2011Operating Grant

Principal investigators: Cobb, Jennifer A

Keywords: Cancer Predisposition; Chip-On-Chip; Chromatin Immunoprecipitation; Dna Repliciation; Genomic Rearrangements; Yeast Genomics

$746,425

The ING Epigenetic Chromatin Regulators in Apoptosis and Oncolysis

Co-investigatorCIHR2009Team Grant: Terry Fox New Frontiers Program in Cancer (LOI)

Principal investigators: Riabowol, Karl T; Lees-Miller, Susan P; Morris, Donald G

Keywords: Apoptosis; Chromatin Regulation; Hdac Inhibitors -Dna Damage And Repair; Ing1 Tumor Suppressor; Mechanism; Model Systems

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Jennifer Cobb

Biochemistry and Microbiology

1 shared papers, latest 2024

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A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2020

Subject: Prospective PhD student: Dna Repair Dear Professor Cobb, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Intrinsic disorder of a nucleoplasmin-like histone chaperone specifies its discrete nuclear and nucleolar functions." (2024), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "The role of Nej1 in DSB repair pathway choice and MMEJ" (2020), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]