Jonathan Lytton, University of Calgary

Research

Calcium Flux Calcium Homeostasis Cerebrospinal Fluid Choroid Plexus Potassium-Dependent Sodium/Calcium-Exchange Secretion Calcium Signalling Diabetes

Latest papers

NCKX4 regulates hippocampal Ca2+ homeostasis and contributes to contextual memory and anxiety-related behaviours.
Cell calcium · 2026 · senior author
Cellular and subcellular distribution of the K+-dependent Na+/Ca2+-exchanger subtype 4, NCKX4, in mouse brain.
Neuroscience · 2025 · senior author
Sodium/(calcium + potassium) exchanger NCKX4 optimizes KLK4 activity in the enamel matrix microenvironment to regulate ECM modeling.
Frontiers in physiology · 2023

All 14 publications

Latest funding

Regulation of K-dependent Na/Ca-exchanger subtype 4, NCKX4
NSERC · 2022 · Principal investigator
$96,000
Determining the functional role for the K-dependent Na/Ca-exchanger subtype 4, NCKX4, in choroid plexus epithelial cells.
CIHR · 2022 · Nominated PI
$100,000
Obesity, Diabetes & Eating Disorders: The role of Calcium Signaling and the Calcium Transporter, NCKX4
CIHR · 2016 · Nominated PI
$936,515

All 6 grants and awards

14 publications.

01

NCKX4 regulates hippocampal Ca2+ homeostasis and contributes to contextual memory and anxiety-related behaviours.

Hassan MT, Bomfim GHS, Patel N, Radhakrishnan SK, Lacruz RS, Lytton J

Cell calcium2026Senior author

DOI: 10.1016/j.ceca.2026.103126 PMID: 41713129

02

Cellular and subcellular distribution of the K+-dependent Na+/Ca2+-exchanger subtype 4, NCKX4, in mouse brain.

Hassan MT, Radhakrishnan SK, Sharma S, Lytton J

Neuroscience2025Senior author

DOI: 10.1016/j.neuroscience.2025.02.013 PMID: 39923981

03

Sodium/(calcium + potassium) exchanger NCKX4 optimizes KLK4 activity in the enamel matrix microenvironment to regulate ECM modeling.

Chan B, Cheng IC, Rozita J, Gorshteyn I, Huang Y, Shaffer I, Chang C, Li W, Lytton J, Den Besten P, Zhang Y

Frontiers in physiology2023

DOI: 10.3389/fphys.2023.1116091 PMID: 36814474

04

Regulation of K+-Dependent Na+/Ca2+-Exchangers (NCKX).

Al-Khannaq M, Lytton J

International journal of molecular sciences2022Senior author

DOI: 10.3390/ijms24010598 PMID: 36614039

05

K+-Dependent Na+/Ca2+ Exchanger Isoform 2, Nckx2, Takes Part in the Neuroprotection Elicited by Ischemic Preconditioning in Brain Ischemia.

Cuomo O, Sirabella R, Boscia F, Casamassa A, Lytton J, Annunziato L, Pignataro G

International journal of molecular sciences2022

DOI: 10.3390/ijms23137128 PMID: 35806133

06

Calmodulin binds and modulates K+-dependent Na+/Ca2+-exchanger isoform 4, NCKX4.

Thibodeau S, Yang W, Sharma S, Lytton J

The Journal of biological chemistry2021Senior author

DOI: 10.1074/jbc.ra120.015037 PMID: 33199372

07

Signal pathway analysis of selected obesity-associated melanocortin-4 receptor class V mutants.

Sharma S, Thibodeau S, Lytton J

Biochimica et biophysica acta. Molecular basis of disease2020Senior author

DOI: 10.1016/j.bbadis.2020.165835 PMID: 32423884

08

Potassium-dependent sodium-calcium exchanger (NCKX) isoforms and neuronal function.

Hassan MT, Lytton J

Cell calcium2020Senior author

DOI: 10.1016/j.ceca.2019.102135 PMID: 31846835

09

An essential role for the K+-dependent Na+/Ca2+-exchanger, NCKX4, in melanocortin-4-receptor-dependent satiety.

Li XF, Lytton J

The Journal of biological chemistry2014Senior author

DOI: 10.1074/jbc.m114.564450 PMID: 25096581

10

Purinergic stimulation of K+-dependent Na+/Ca2+ exchanger isoform 4 requires dual activation by PKC and CaMKII.

Yang X, Lytton J

Bioscience reports2013Senior author

DOI: 10.1042/bsr20130099 PMID: 24224486