Justin MacDonald

Biochemical mechanisms of inflammasome function

Principal investigators: MacDonald, Justin

Keywords: protein biochemistry; enzyme catalysis; targeted proteomics; protein-protein interactions; recombinant protein production systems; structural biology; mass spectrometry; post-translational modifications; innate immune system signaling; nod-like receptor with pyrin domain (nlrp)

Biochemical mechanisms underlying inflammasome function

Principal investigators: Macdonald, Justin

The functional role of zipper-interacting protein kinase in vascular smooth muscle contraction.

Principal investigators: Macdonald, Justin A

Keywords: Cell Motility; Chemical Genetics And Proteomics; Hypertension; Mass Spectrometry; Peripheral Resistance & Myogenic Tone; Protein Kinase; Protein Structure & Function; Small Molecule Inhibitor; Vascular Smooth Muscle; Zipper-Interacting Protein Kinase

The functional role of zipper-interacting protein kinase in vascular smooth muscle hypercontractile pathologies.

Principal investigators: Turner, Sara R

Keywords: Animal Models Of Disease; Cerebral Blood Flow; Cerebrovasospasm; Drug Development; Human Tissues; Hypertension; Stroke; Translational Research; Zipper-Interacting Protein Kinase

Investigating the increased severity of Clostridium difficile infection and Clostridium difficile toxin induced injury in Inflammatory Bowel Disease

Principal investigators: Tulk, Sarah E

Keywords: Clostridium Difficile; Cytokines; Infectious Colitis; Inflammasome; Inflammatory Bowel Disease; Inflammatory Signalling; Intestinal Inflammation

International Conference on Advances in Gastrointestinal Physiology & Treatment in Gastroenterology

Principal investigators: McKay, Derek M

Keywords: Digestive; Gastrointestinal; Inflammation; Liver; Microbe

Hypoxia-inducible factor-1 (HIF-1) plays an innate protective role in Clostridium difficile-induced colitis

Principal investigators: Beck, Paul L

Keywords: Clostridium Difficile; Colitis; Epithelial Barrier Dysfunction; Hypoxia Inducible Factor-1 Alpha; Mucosal Inflammation; Post-Translation Modifications; Signal Transduction

Nitric oxide stabilizes HIF-1 and acts to protect intestinal barrier function during Clostridium difficile-induced colitis.

Principal investigators: Traboulsi, Danya

Keywords: Clostridium Difficile; Colitis; Hypoxia Inducible Factor; Inflammation; Intestinal Epithelium; Nitric Oxide; Toxic Megacolon

The role of the inflammasome in the pathogenesis of Clostridium difficile-associated disease.

Principal investigators: Hirota, Simon A

Keywords: Clostridium Difficile; Diarrhea; Gastrointestinal; Inflammasome; Inflammation; Innate Immune System; Interleukin-1beta; Intestinal Barrier Function; Mucosal Immunity; Nalp

Smoothelin like-1 interacts with apo-calmodulin and tropomyosin to regulate Ca2+-dependent contractile signaling in vascular smooth muscle cells.

Principal investigators: Macdonald, Justin A

Keywords: Calcium Desensitization; Calmodulin; Contraction; Mass Spectrometry; Protein Structure/Function; Relaxation; Smoothelin; Tropomyosin; Vascular Smooth Muscle