Faculty profile
Mark Giembycz
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Research
Latest papers
Editorial: Phosphodiesterases as Drug Targets in Airway and Inflammatory Diseases.
Frontiers in pharmacology · 2021
Latest funding
- $852,976
Biased Agonism Mediated by the Glucocorticoid Receptor
CIHR · 2023 · Nominated PI
- $100,000
Biased Agonism Mediated by the Glucocorticoid Receptor
CIHR · 2022 · Nominated PI
- $879,750
Understanding glucocorticoid resistance in inflammatory disease
CIHR · 2021 · Co-investigator
1 publications.
Editorial: Phosphodiesterases as Drug Targets in Airway and Inflammatory Diseases.
Mokry J, Giembycz M, Mokra D
Biased Agonism Mediated by the Glucocorticoid Receptor
Principal investigators: Giembycz, Mark A
Keywords: Biased Agonism; Glucocorticoid Receptor; Molecular Pharmacology; Pharmacodynamics
Biased Agonism Mediated by the Glucocorticoid Receptor
Principal investigators: Giembycz, Mark A
Keywords: Biased Agonism; Glucocorticoid Receptor; Molecular Pharmacology; Pharmacodynamics
Understanding glucocorticoid resistance in inflammatory disease
Principal investigators: Newton, Robert
Keywords: Gene Regulation; Glucocorticoid Action; Glucocorticoid Resistance; Inflammation; Molecular Pharmacology; Nuclear Hormone Receptor
Biased Agonism Mediated by the Glucocorticoid Receptor
Principal investigators: Giembycz, Mark
Molecular mechanisms underlying the clinical efficacy of inhaled corticosteroid/long-acting beta2-adrenoceptor agonist combination therapies in asthma
Principal investigators: Newton, Robert
Keywords: Asthma; Beta2-Adrenoceptor; Glucocorticoid; Regulation; Signal Transduction; Therapy; Transcription
Molecular mechanisms underlying the enhanced efficacy of inhaled corticosteroid/long-acting beta2-adrenoceptor agonist combinations used in asthma
Principal investigators: Newton, Robert
Keywords: Gene Expression; Glucocorticoids / Corticosteroids; Long-Acting Beta2-Agonists; Regulation; Transcriptional Control
Role of Gene Expression Changes in the Mechanism of Action of Long-acting Beta2-adrenoceptor Agonists in COPD
Principal investigators: Giembycz, Mark A
Keywords: Camp; Crispld2; Drug Action; Exacerbations; Gene Expression; Long-Acting Beta2-Agonists; Obstructive Lung Diseases; Rgs2
cAMP-Dependent gene transactivation: a novel mechanism underlying the anti-inflammatory activity of PDE4 inhibitors in COPD.
Principal investigators: Sharma, Pawan
Keywords: Chronic Obstructive Pulmonary Disease; Epithelial Cells; Gene Transactivation; Phosphodiesterase 4; Roflumilast
CANADA RESEARCH CHAIRHOLDER – TIER 1 / TITULAIRE DE CHAIRE DE RECHERCHE DU CANADA – NIVEAU 1
Principal investigators: Giembycz, Mark A
Keywords: Tier 1 Crc
A Unifying Mechanism for the Anti-inflammatory Effect of Phosphodiesterase 4 Inhibitors in Chronic Obstructive Pulmonary Disease
Principal investigators: Giembycz, Mark A
Keywords: 15-Lipoxygenase; Airways Inflammation; Copd; Cyclic Nucleotides; Peroxisome Proliferator-Activated Recepotor Gamma; Phosphodiesterase 4 Inhibitors
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
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