Faculty profile

Ute Kothe

ResearcherChemistry and BiochemistryUniversity of Lethbridge

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Lethbridge directory, so their courses may be missing. Find their university profile.

Ute Kothe

Researcher

Chemistry and Biochemistry

Health Sciences

University of Lethbridge

Lethbridge, Alberta, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
6 publications in the last five years, latest in 2024.
Senior (last) author on 5 recent papers, a sign of leading a research group.
Principal investigator on 10 research grants (6 CIHR, 4 NSERC), most recently in 2020.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

Search on Google Scholar

Find them onX · LinkedIn · Bluesky · YouTube

Signals and details

Research

Cryo-Electron Microscopy Fluorescence Ribonucleoprotein Ribosome Biogenesis Rna Folding Rna Modification Rrna Processing Saccharomyces Cerevisiae

Latest papers

RNA modifying enzymes shape tRNA biogenesis and function.
The Journal of biological chemistry · 2024 · senior author
Modifications in the T arm of tRNA globally determine tRNA maturation, function, and cellular fitness.
Proceedings of the National Academy of Sciences of the United States of America · 2024 · senior author
Molecular mechanism of tRNA binding by the Escherichia coli N7 guanosine methyltransferase TrmB.
The Journal of biological chemistry · 2023 · senior author

All 26 publications

Latest funding

23rd RiboClub Annual Meeting
CIHR · 2022 · Co-investigator
$10,000
Identifying Critical RNA-RNA Interactions during Ribosome Biogenesis
CIHR · 2020 · Nominated PI
$642,600
Mechanism and function of tRNA modification and folding
NSERC · 2020 · Principal investigator
$290,000

All 14 grants and awards

26 publications.

RNA modifying enzymes shape tRNA biogenesis and function.

Schultz SK, Kothe U

The Journal of biological chemistry2024Senior author

DOI: 10.1016/j.jbc.2024.107488 PMID: 38908752

Modifications in the T arm of tRNA globally determine tRNA maturation, function, and cellular fitness.

Schultz SK, Katanski CD, Halucha M, Peña N, Fahlman RP, Pan T, Kothe U

Proceedings of the National Academy of Sciences of the United States of America2024Senior author

DOI: 10.1073/pnas.2401154121 PMID: 38889150

Molecular mechanism of tRNA binding by the Escherichia coli N7 guanosine methyltransferase TrmB.

Schultz SK, Meadows K, Kothe U

The Journal of biological chemistry2023Senior author

DOI: 10.1016/j.jbc.2023.104612 PMID: 36933808

Fluorescent labeling of tRNA for rapid kinetic interaction studies with tRNA-binding proteins.

Schultz SK, Kothe U

Methods in enzymology2023Senior author

DOI: 10.1016/bs.mie.2023.05.007 PMID: 37925176

Multi-wavelength analytical ultracentrifugation of biopolymer mixtures and interactions.

Henrickson A, Gorbet GE, Savelyev A, Kim M, Hargreaves J, Schultz SK, Kothe U, Demeler B

Analytical biochemistry2022

DOI: 10.1016/j.ab.2022.114728 PMID: 35609686

Synergistic interaction network between the snR30 RNP, Utp23, and ribosomal RNA during ribosome synthesis.

Vos TJ, Kothe U

RNA biology2022Senior author

DOI: 10.1080/15476286.2022.2078092 PMID: 35648701

The human pseudouridine synthase PUS7 recognizes RNA with an extended multi-domain binding surface.

Guegueniat J, Halabelian L, Zeng H, Dong A, Li Y, Wu H, Arrowsmith CH, Kothe U

Nucleic acids research2021Senior author

DOI: 10.1093/nar/gkab934 PMID: 34718722

Revisiting tRNA chaperones: new players in an ancient game.

Porat J, Kothe U, Bayfield MA

RNA (New York, N.Y.)2021

DOI: 10.1261/rna.078428.120 PMID: 33593999

H/ACA Small Ribonucleoproteins: Structural and Functional Comparison Between Archaea and Eukaryotes.

Czekay DP, Kothe U

Frontiers in microbiology2021Senior author

DOI: 10.3389/fmicb.2021.654370 PMID: 33776984

Partially modified tRNAs for the study of tRNA maturation and function.

Schultz SK, Kothe U

Methods in enzymology2021Senior author

DOI: 10.1016/bs.mie.2021.06.007 PMID: 34517948

23rd RiboClub Annual Meeting

Co-investigatorCIHR2022Planning and Dissemination Grant - Institute Community Support

Principal investigators: Scott, Michelle

Keywords: Deregulation In Disease; Gene Expression Regulation; Regulatory Rna; Rna Biology; Rna Complexes; Rna Delivery; Rna In Biotechnology; Rna Interactions; Rna Structure; Transcriptomics

$10,000

Identifying Critical RNA-RNA Interactions during Ribosome Biogenesis

Nominated PICIHR2020Project Grant

Principal investigators: Kothe, Ute

Keywords: Cryo-Electron Microscopy; Fluorescence; Ribonucleoprotein; Ribosome Biogenesis; Rna Folding; Rna Modification; Rrna Processing; Saccharomyces Cerevisiae; Small Nucleolar Rna (Snorna); Transcriptomics

$642,600

Mechanism and function of tRNA modification and folding

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Kothe, Ute

$290,000

Biomolecular Characterization Suite at the University of Lethbridge

Co-investigatorNSERC2020Research Tools and Instruments

Principal investigators: Patel, Trushar

$150,000

Mechanism and function of tRNA modification and folding

Principal investigatorNSERC2020Discovery Grants Program - Accelerator Supplements

Principal investigators: Kothe, Ute

$120,000

RNA Bioengineering and Innovation Network

Co-investigatorNSERC2018Collaborative Research and Training Experience

Principal investigators: Wieden, HansJoachim

$1,650,000

11th International Ribosome Synthesis Conference

Nominated PICIHR2017Planning and Dissemination Grant - Institute Community Support

Principal investigators: Kothe, Ute

Keywords: Bacterial Infection; Cancer; Conference; Inherited Disease; Networking; Nucleolus; Protein; Ribosome; Rna; Training

$10,000

RiboWest Conference 2016

Nominated PICIHR2016Planning and Dissemination Grant - Institute Community Support

Principal investigators: Kothe, Ute

Keywords: Gene Expression And Regulation; Ribonucleic Acid (Rna); Scientific Meeting; Synthetic Biology

$10,000

Preparative ultracentrifuge for the study of ribonucleoprotein complexes, their structure, function, and rational engineering.

Co-investigatorNSERC2014Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Wieden, HansJoachim

$71,883

Function and Mechanism of RNA Modification

Principal investigatorNSERC2014Discovery Grants Program - Individual

Principal investigators: Kothe, Ute

$246,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Something wrong or missing on this profile? Suggest a correction