Faculty profile
Glen Tibbits
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Research
Latest funding
- $150,000
SSM-based electrophysiology instrument to study electrogenic transporters
NSERC · 2025 · Co-investigator
- $895,050
Mechanism-based targeted rescue of hERG channel dysfunction in hiPSC-CMs
CIHR · 2023 · Co-investigator
- $25,000
Use of novel bioengineering technology to yield matured cardiomyocytes derived from hiPSCs
NSERC · 2023 · Principal investigator
SSM-based electrophysiology instrument to study electrogenic transporters
Principal investigators: Parker, Seth
Keywords: solute carriers; transporters; ion channels; electrophysiology; metabolism; ions; membranes; organelles; amino acids
Mechanism-based targeted rescue of hERG channel dysfunction in hiPSC-CMs
Principal investigators: Claydon, Thomas W
Keywords: Activator Drugs; Cell Patterning; Crispr-Cas9; Electrophysiology; Herg Potassium Channels; Human Induced Pluripotent Cells; Long Qt Syndrome; Mathematical Modeling; Multi-Electrode Array; Optical Mapping
Use of novel bioengineering technology to yield matured cardiomyocytes derived from hiPSCs
Principal investigators: Tibbits, Glen GF
Keywords: cardiac arrhythmias; hiPSC-CM maturation; hiPSC-derived cardiomyocytes; hiPSC differentiation; materials science; mechanosensing
To examine the stress-mediated profibrotic and arrhythmic response in clinically relevant hypertrophic cardiomyopathy associated cardiac troponin-T (TNNT2) gene variants.
Principal investigators: Nagalingam, Raghu Sundaresan
Keywords: Cardiac Fibrosis; Crispr Gene Editing; Electrophysiology; Hypertrophic Cardiomyopathy; Induced Pluripotent Stem Cell-Derived Cardiomyocytes; Induced Pluripotent Stem Cell-Derived Fibroblasts
Regulation of contractility in the teleost heart
Principal investigators: Tibbits, Glen
High-pressure freezing unit for visualizing cellular ultrastructure by electron microscopy
Principal investigators: Beh, Christopher
Arrhythmogenic mutations in the neonate cardiac contractile element
Principal investigators: Tibbits, Glen F
Keywords: Arrhythmogenesis; Cardiac Thin Filament; Induced Pluripotent Stem Cell Dervied Cardiomyocytes; Infants; Sudden Cardiac Arrest
Investigating drug therapies for inherited and acquired long QT syndrome using iPSC-derived cardiomyocytes and zebrafish whole hearts as translational models
Principal investigators: Claydon, Thomas W
Keywords: Activator Drugs; Crispr Genome Editing; Electrophysiology; Herg Potassium Channel; Induced Pluripotent Stem Cells; Long Qt Syndrome
A super-resolution microscope for visualizing cellular structure and dynamics
Principal investigators: Beh, Christopher
Familial hypertrophic cardiomyopathy: etiology involving troponin mutations
Principal investigators: Tibbits, Glen F
Keywords: Arrhythmias; Cardiac Hypertrophy; Cryo-Em; Length-Dependent Activation; Molecular Dynamic Simulations; Optical Mapping; Sudden Cardiac Death
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
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