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Research
Latest papers
Pharmacological Inhibition of O-GlcNAcase Enhances Autophagy in Brain through an mTOR-Independent Pathway.
ACS chemical neuroscience · 2018
Latest funding
- $120,000
Characterizing molecular mechanisms of disease progression and treatment resistance in pancreatic neuroendocrine neoplasms
CIHR · 2025 · Supervisor
- $994,500
Targeting adaptive autophagy to enhance treatment response in pancreatic cancer
CIHR · 2024 · Nominated PI
- $994,500
Caspase regulation of cellular stress responses in breast cancer.
CIHR · 2023 · Nominated PI
1 publications.
Pharmacological Inhibition of O-GlcNAcase Enhances Autophagy in Brain through an mTOR-Independent Pathway.
Zhu Y, Shan X, Safarpour F, Erro Go N, Li N, Shan A, Huang MC, Deen M, Holicek V, Ashmus R, Madden Z, Gorski S, Silverman MA, Vocadlo DJ
Characterizing molecular mechanisms of disease progression and treatment resistance in pancreatic neuroendocrine neoplasms
Principal investigators: Gidda, Arlene K
Keywords: Autophagy; Pancreatic Neuroendocrine Neoplasms; Treatment Resistance
Targeting adaptive autophagy to enhance treatment response in pancreatic cancer
Principal investigators: Gorski, Sharon M
Keywords: Atg4; Autophagy; Biomarker; Cell Lines; Hydroxychloroquine; Mouse Model; Organoids; Pancreatic Cancer; Proof-Of-Principle; Treatment Resistance
Caspase regulation of cellular stress responses in breast cancer.
Principal investigators: Gorski, Sharon M
Keywords: Autophagy; Breast Cancer; Casp3; Casp7; Caspase; Cell Death; Cell Lines; Immunoprecipitation Mass Spectrometry; Mouse Model; Stress Adaptation
Targeting adaptive autophagy to enhance treatment response in pancreatic cancer
Principal investigators: Gorski, Sharon M
Keywords: Atg4; Autophagy; Biomarker; Cell Lines; Hydroxychloroquine; Mouse Model; Organoids; Pancreatic Cancer; Proof-Of-Principle; Treatment Resistance
Caspase regulation of cellular stress responses in breast cancer.
Principal investigators: Gorski, Sharon M
Keywords: Autophagy; Breast Cancer; Casp3; Casp7; Caspase; Cell Death; Cell Lines; Immunoprecipitation Mass Spectrometry; Mouse Model; Stress Adaptation
Caspase regulation of cellular stress responses in breast cancer.
Principal investigators: Gorski, Sharon M
Keywords: Autophagy; Breast Cancer; Caspase 7; Cell Lines; Cell Signaling; Mass Spectrometry; Mouse Model; Parp; Protein Interaction; Stress Response
Cellular and physiological roles of autophagy-related proteins in Drosophila.
Principal investigators: Gorski, Sharon
ATG4B inhibition for the sensitization of treatment-resistant HER2+ cancers
Principal investigators: Ho, Cally
Keywords: Anti-Her2 Agents; Atg4b; Autophagy; Breast Cancer; Her2; Proteomics; Trastuzumab; Treatment Resistance
Deciphering a contribution by Parkinson's susceptibility gene LRRK2 to lung cancer immunosuppression
Principal investigators: Gorski, Sharon M
Keywords: Environment Cancer
High-pressure freezing unit for visualizing cellular ultrastructure by electron microscopy
Principal investigators: Beh, Christopher
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
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