Thomas Claydon, Simon Fraser University

Research

Activator Drugs Electrophysiology Long Qt Syndrome Cell Patterning Crispr-Cas9 Herg Potassium Channels Human Induced Pluripotent Cells Mathematical Modeling

Latest papers

Loss-of-Function and Gain-of-Function Mutations in KCNQ5 Cause Intellectual Disability or Epileptic Encephalopathy.
American journal of human genetics · 2017
Photothermal release of small molecules from gold nanoparticles in live cells.
Nanomedicine : nanotechnology, biology, and medicine · 2012

All 2 publications

Latest funding

Impacts of TSC2 loss on Early Neural Development
CIHR · 2026 · Co-investigator
$1,071,000
Mechanism-based targeted rescue of hERG channel dysfunction in hiPSC-CMs
CIHR · 2023 · Nominated PI
$895,050
Using zebrafish to study developmental and environmental plasticity of cardiac K+ channel transcript expression
NSERC · 2020 · Principal investigator
$252,000

All 6 grants and awards

2 publications.

01

Loss-of-Function and Gain-of-Function Mutations in KCNQ5 Cause Intellectual Disability or Epileptic Encephalopathy.

Lehman A, Thouta S, Mancini GMS, Naidu S, van Slegtenhorst M, McWalter K, Person R, Mwenifumbo J, Salvarinova R, CAUSES Study, EPGEN Study, Guella I, McKenzie MB, Datta A, Connolly MB, Kalkhoran SM, Poburko D, Friedman JM, Farrer MJ, Demos M, Desai S, Claydon T

American journal of human genetics2017

DOI: 10.1016/j.ajhg.2017.05.016 PMID: 28669405

02

Photothermal release of small molecules from gold nanoparticles in live cells.

Zandberg WF, Bakhtiari AB, Erno Z, Hsiao D, Gates BD, Claydon T, Branda NR

Nanomedicine : nanotechnology, biology, and medicine2012

DOI: 10.1016/j.nano.2011.10.012 PMID: 22100758

Impacts of TSC2 loss on Early Neural Development

Co-investigatorCIHR2026Project Grant

Principal investigators: Julian, Lisa M

Keywords: Brain Development; Cell Fate Decisions; Cell Identity; Er Stress; Neural Stem Cells; Omics Analyses; Pluripotent Stem Cells; Protein Translation; Proteostasis; Unfolded Protein Response

$1,071,000

Mechanism-based targeted rescue of hERG channel dysfunction in hiPSC-CMs

Nominated PICIHR2023Project Grant

Principal investigators: Claydon, Thomas W

Keywords: Activator Drugs; Cell Patterning; Crispr-Cas9; Electrophysiology; Herg Potassium Channels; Human Induced Pluripotent Cells; Long Qt Syndrome; Mathematical Modeling; Multi-Electrode Array; Optical Mapping

$895,050

Using zebrafish to study developmental and environmental plasticity of cardiac K+ channel transcript expression

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Claydon, Thomas

$252,000

Investigating drug therapies for inherited and acquired long QT syndrome using iPSC-derived cardiomyocytes and zebrafish whole hearts as translational models

Nominated PICIHR2017Project Grant

Principal investigators: Claydon, Thomas W

Keywords: Activator Drugs; Crispr Genome Editing; Electrophysiology; Herg Potassium Channel; Induced Pluripotent Stem Cells; Long Qt Syndrome

$680,850

Science in the Community

Co-investigatorCIHR2011CIHR Café Scientifique Program

Principal investigators: Marigold, Daniel

Keywords: Chronic Disease; Community Engagement; Falls; Health

$3,000

Fluorimetric analysis of voltage-gated ion channel gating

Principal investigatorNSERC2008Discovery Grants Program - Individual

Principal investigators: Claydon, Thomas

$150,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2023

Subject: Prospective PhD student: Activator Drugs Dear Professor Claydon, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Loss-of-Function and Gain-of-Function Mutations in KCNQ5 Cause Intellectual Disability or Epileptic Encephalopathy." (2017), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Mechanism-based targeted rescue of hERG channel dysfunction in hiPSC-CMs" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]