François Jean

Cryo-Em of Human V-ATPase-Cladoniamide A Analog Complexes for Structure-Based Antiviral Drug Design

Principal investigators: Thompson, Connor A

Keywords: Antiviral Drug Design

Catalyzing One Health Research on Highly Pathogenic H5N1 Avian Influenza A (HPAI H5N1) Viruses: An integrated transdisciplinary approach using translational genomics, AI-driven modeling, and phenotypic profiling

Principal investigators: Jean, François

Keywords: Antiviral Drugs; Artificial Intelligence (Ai)-Based Molecular Modeling; Cell-Based Assays; H5n1 Structural Proteins; Highly Pathogenic H5n1 Avian Influenza A Viruses; Molecular Virology; One Health Research - H5n1 Viruses; Pseudoviruses; Translational Genomics; Virus-Host Cell Interactions

Pre-clinical development of a novel class of broad-spectrum natural product antivirals

Principal investigators: Jean, François

Keywords: Animal Models Of Viral Infection; Antiviral Drug Discovery; Antiviral Properties; Broad-Spectrum Antivirals; Emerging Human Viruses Of International Concerns; Host-Directed Antivirals; Medicinal Chemistry; Natural Product Antivirals; Pharmaceutical Properties; Pharmacognosy

Molecular and cellular studies of novel broad-spectrum natural product antivirals against respiratory viruses of pandemic concern

Principal investigators: Thompson, Connor A

Keywords: Antiviral Drug Combinations And Synergy; Antiviral Drug Discovery; Antiviral Properties And Preclinical Development; Broad-Spectrum Antivirals; Computational Approaches To Structural Biology; Emerging Human Viruses Of International Concern; Host-Directed Antivirals; Medicinal Chemistry; Natural Product Antivirals; Pandemic Preparedness

Pre-clinical development of broad-spectrum antiviral strategies against human respiratory viruses of pandemic concern

Principal investigators: Jean, François; Boudreault, Pierre-Luc; Leduc, Richard

Keywords: Antiviral Drug Development; Broad-Spectrum Antivirals; Enzymology; Influenza A Virus; Medicinal Chemistry; Pharmacognosy; Sars-Cov-2 Variants Of Concern; Transmembrane Serine Protease 2 (Tmprss2); Viral Envelope Glycoprotein; Virology

tauSTED: Fluorescent Lifetime Upgrade for Stimulated Emission Depletion Super-Resolution Microscope

Principal investigators: Nabi, Ivan

COVID-19 Variant Supplement - Preventing SARS-CoV-2 infection by targeting human type II transmembrane serine protease activity

Principal investigators: Leduc, Richard

Keywords: Host Protease; Protease Inhibitors; Serine Protease

COVID-19 Variant Supplement - Computer-aided discovery of synergistic drug combinations with Remdevisir for COVID-19 through mechanism-based drug repurposing and combinatorial organoid screening.

Principal investigators: Cherkasov, Artem; Jean, François

Keywords: Drug And Natural Product Repurposing; Enable High-Quality Data On Existing Covid-19 Treatment; Enhance Canadian Engagement In Large Scale Trials; Enhance Engagement With Middle-Income & Low-Income Countries; Evidences For Clinical & Public Health Decision Makers; Idenitfy Remdesivir Synergistic Drugs; National And International Coordination For Sharing Of Data; New Covid-19 Treatment For Interventions And Prevention; Rapid Deployment Of Existing Research Platforms; Sex As A Biological Variable

COVID-19 Variant Network - Computer-aided discovery of synergistic drug combinations with Remdevisir for COVID-19 through mechanism-based drug repurposing and combinatorial organoid screening.

Principal investigators: Cherkasov, Artem; Jean, François

Keywords: Drug And Natural Product Repurposing; Enable High-Quality Data On Existing Covid-19 Treatment; Enhance Canadian Engagement In Large Scale Trials; Enhance Engagement With Middle-Income & Low-Income Countries; Evidences For Clinical & Public Health Decision Makers; Idenitfy Remdesivir Synergistic Drugs; National And International Coordination For Sharing Of Data; New Covid-19 Treatment For Interventions And Prevention; Rapid Deployment Of Existing Research Platforms; Sex As A Biological Variable

Sex as a Biological Variable Supplement - Augmented Discovery of Potential Inhibitors of SARS-CoV-2 3CL Protease

Principal investigators: Cherkasov, Artem

Keywords: Biomedical Research