Faculty profile
Joanne Matsubara
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Research
Latest papers
Blue light-induced phototoxicity in retinal cells: implications in age-related macular degeneration.
Frontiers in aging neuroscience · 2024 · senior author
Granzyme B Expression in Conjunctiva of Patients with Pterygium.
International journal of molecular sciences · 2024
Early inner plexiform layer thinning and retinal nerve fiber layer thickening in excitotoxic retinal injury using deep learning-assisted optical coherence tomography.
Acta neuropathologica communications · 2024
Latest funding
- $478,126
Establishment of a novel multi-parametric assessment protocol for identification of distinctive pathological pathways in age-related macular degeneration
CIHR · 2025 · Principal investigator
- $120,000
Comprehensive Investigation of Molecular Mechanisms and Therapeutic Potential of Extracellular Granzyme B in Pterygium
CIHR · 2025 · Supervisor
- $1,051,875
Extracellular Granzyme B Accumulates with Aging and Promotes Age-related Macular Degeneration (AMD)
CIHR · 2024 · Nominated PI
10 publications.
Blue light-induced phototoxicity in retinal cells: implications in age-related macular degeneration.
Chakravarthy H, Georgyev V, Wagen C, Hosseini A, Matsubara J
Granzyme B Expression in Conjunctiva of Patients with Pterygium.
Choi Y, Samad I, Chakravarthy H, Matsubara J, Granville DJ, Yeung SN
Early inner plexiform layer thinning and retinal nerve fiber layer thickening in excitotoxic retinal injury using deep learning-assisted optical coherence tomography.
Ma D, Deng W, Khera Z, Sajitha TA, Wang X, Wollstein G, Schuman JS, Lee S, Shi H, Ju MJ, Matsubara J, Beg MF, Sarunic M, Sappington RM, Chan KC
Reply.
Mammo Z, Guo M, Maberley D, Matsubara J, Etminan M
Oral Bisphosphonates and Risk of Wet Age-Related Macular Degeneration.
Mammo Z, Guo M, Maberley D, Matsubara J, Etminan M
Pro-inflammatory and anti-angiogenic effects of bisphosphonates on human cultured retinal pigment epithelial cells.
Or C, Cui J, Matsubara J, Forooghian F
Optical coherence tomography-based correlation between choroidal thickness and drusen load in dry age-related macular degeneration.
Ko A, Cao S, Pakzad-Vaezi K, Brasher PM, Merkur AB, Albiani DA, Kirker AW, Cui J, Matsubara J, Forooghian F
PDGF receptors are activated in human epiretinal membranes.
Cui J, Lei H, Samad A, Basavanthappa S, Maberley D, Matsubara J, Kazlauskas A
Amyloid-beta deposits lead to retinal degeneration in a mouse model of Alzheimer disease.
Ning A, Cui J, To E, Ashe KH, Matsubara J
Complement-associated deposits in the human retina.
Seth A, Cui J, To E, Kwee M, Matsubara J
Establishment of a novel multi-parametric assessment protocol for identification of distinctive pathological pathways in age-related macular degeneration
Principal investigators: Ju, MyeongJin; Matsubara, Joanne A
Keywords: Age-Related Macular Degeneration; Angiography; Optical Coherence Tomography; Optoretinography; Polarimetry Imaging; Retina
Comprehensive Investigation of Molecular Mechanisms and Therapeutic Potential of Extracellular Granzyme B in Pterygium
Principal investigators: Hosseini, Amirali
Keywords: Aging Eye; Granzyme B; Immune Cell Characterization; In Vitro And Ex Vivo Models; Neovascularization And Fibrosis; Ocular Surface; Ocular Surface Squamous Neoplasia; Pterygium; Therapeutics; Ultraviolet Exposure
Extracellular Granzyme B Accumulates with Aging and Promotes Age-related Macular Degeneration (AMD)
Principal investigators: Matsubara, Joanne A; Ju, MyeongJin
Keywords: Age-Related Macular Degeneration; Cell Culture; Extracellular Matrix; Healthy Aging; Mast Cell; Mouse Models; Outer Blood Retinal Barrier; Pathological Aging; Protease
Preventing abnormal blood vessel growth in age-related macular degeneration by inhibiting granzyme B activity
Principal investigators: Yoo, Hyung Suk
Keywords: Age-Related Macular Degeneration; Choroidal Neovascularization; Retinal Neurodegeneration; Subretinal Fibrosis
Multiphoton Photothermolysis Based Laser Therapy for Precision Treatment of Neovascular Eye Diseases
Principal investigators: Zeng, Haishan; Lui, Harvey; Matsubara, Joanne A; Yeung, Sonia N
Keywords: Biophotonics; Confocal Microscopy; Corneal Neovascularization; Diabetic Retinopathy; Eye Diseases; Laser Therapy; Macular Degeration; Multiphoton Microscopy; Multiphoton Photothermolysis; Ophthalmology
Treating advanced retinal degeneration - rebuilding multiple co-dependent retinal layers with stem cells
Principal investigators: Matsubara, Joanne A
Keywords: Combined Rpe And Photoreceptor Graft; Rebuilding Multiple Lost Retinal Layers; Regenerative Ophthalmology; Retinal Degenerative Diseases; Stem-Cell- And Device-Based Therapy
Regulation of inflammasome activity by a classic anti-apoptotic protein, XIAP.
Principal investigators: Matsubara, Joanne
Regulation of inflammasome activity by a classic anti-apoptotic protein, XIAP.
Principal investigators: Matsubara, Joanne
Regulation of inflammasome activity by a classic anti-apoptotic protein, XIAP.
Principal investigators: Matsubara, Joanne
Treating advanced retinal degeneration - rebuilding multiple co-dependent retinal layers with stem cells
Principal investigators: Laver, Christopher R
Keywords: Rebuilding Multiple Lost Retinal Layers; Regenerative Ophthalmology; Retinal Degenerative Diseases; Stem-Cell-Based Theraputics
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
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