This profile is built from public research funding records (CIHR, NSERC and SSHRC). We have not imported them from a University of British Columbia directory, so their publications, courses and email address may be missing. Find their university profile.
Research
Latest funding
- $1,143,676
Molecular Principles Governing Degron Recognition in Misfolded Cytosolic Proteins with Pathological Missense Mutations
CIHR · 2026 · Co-investigator
- $895,050
AI-supported mapping and probing of the regulation of cardiac voltage-gated calcium channels.
CIHR · 2025 · Nominated PI
- $726,750
The Molecular Mechanism of the Secretion of the Bacterial Toxin Adenylate Cyclase
CIHR · 2021 · Co-investigator
Molecular Principles Governing Degron Recognition in Misfolded Cytosolic Proteins with Pathological Missense Mutations
Principal investigators: Mayor, Thibault
Keywords: Bioid Proximity Labeling; Chaperone; Proteasome; Protein Folding; Proteolysis; Proteomics; Proteostasis; Ubiquitin
AI-supported mapping and probing of the regulation of cardiac voltage-gated calcium channels.
Principal investigators: Gsponer, Jörg
Keywords: Calcium Channels; Electrophysiology; Heart Cells; Machine Learning; Protein Engineering; Structural Biology; Structure Prediction; X-Ray Crystallography
The Molecular Mechanism of the Secretion of the Bacterial Toxin Adenylate Cyclase
Principal investigators: Li, Hongbin
Keywords: Bacterial Toxin,; Computational Design; Docking; Intrinsically Disordered Proteins; Optical Tweezers; Protein Folding; Repeats-In-Toxin; Secretion; Single Molecule Biophysics; Whooping Cough
Protein phase separation: A new mechanism of protein function regulation in Mycobacterium tuberculosis
Principal investigators: Gsponer, Jörg; Mcintosh, Lawrence P
Keywords: Computational Biology; Fluorescence Microscopy; Microbial Signal Transduction; Molecular Mechanism Of Virulence; Nmr Spectroscopy; Protein Phase Separation; Proteomic And Protein Interaction Networks; Regulation Of Abc Transporter Activity
Characterization of the proteostasis decline upon aging
Principal investigators: Mayor, Thibault
Keywords: Aggregation; Aging; Chaperone; Heat Shock Proteins (Hsps); Mass Spectrometry; Oxidation; Protein Folding; Protein Homeostasis; Proteomics; Ubiquitin
Mapping the Dynamic Landscape of Genome-wide DNA Methylation, Hydroxymethylation and Transcriptomic Variation in Parkinson Disease
Principal investigators: Gsponer, Jörg
Keywords: Bioinformatics; Dna Methylation; Epigenetics; Medip-Seq; Neurodegenerative Disease; Parkinson'S Disease
Identification of genes that modulate the severity of neurodegenerative diseases
Principal investigators: Gsponer, Jörg
Keywords: Alzheimer; Animal Models; Computational Biology; Disease Network; Genetic Modifiers; Ipscs; Neurodegeneration; Parkinson; Rna Sequencing; Systems Medicine
Deciphering Protein Quality Control Pathways Targeting Cytosolic Proteins for Proteasome Degradation
Principal investigators: Mayor, Thibault
Keywords: Biochemistry; Cell Biology; Mass Spectrometry; Microscopy; Neurodegenerative Diseases; Proteasome; Protein Homeostasis; Protein Quality Control; Ubiquitin; Yeast Genetics
Tool for proteome-wide identification of regulatory switches
Principal investigators: Gsponer, Jörg
Keywords: Autoinhibitory Switch; Cancer Biology; Cell Signaling; Genome/Proteome Annotation; Intrinsically Disordered Proteins
Identification of Generic Supressors of Proteinopathies
Principal investigators: Gsponer, Jörg
Keywords: Alzheimers
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
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