Faculty profile
Lawrence Mcintosh
Back to facultyThis profile is built from public research funding records (CIHR, NSERC and SSHRC). We have not imported them from a University of British Columbia directory, so their publications, courses and email address may be missing. Find their university profile.
Research
Latest funding
- $887,400
Protein phase separation: A new mechanism of protein function regulation in Mycobacterium tuberculosis
CIHR · 2020 · Principal investigator
- $150,000
Microscope for Multicolour Single Molecule Fluorescence Detection, Imaging, and (Cross-)Correlation Spectroscopy
NSERC · 2018 · Co-investigator
- $414,000
Protein Glycosylation: Mechanisms and Consequences
NSERC · 2018 · Principal investigator
Protein phase separation: A new mechanism of protein function regulation in Mycobacterium tuberculosis
Principal investigators: Gsponer, Jörg; Mcintosh, Lawrence P
Keywords: Computational Biology; Fluorescence Microscopy; Microbial Signal Transduction; Molecular Mechanism Of Virulence; Nmr Spectroscopy; Protein Phase Separation; Proteomic And Protein Interaction Networks; Regulation Of Abc Transporter Activity
Microscope for Multicolour Single Molecule Fluorescence Detection, Imaging, and (Cross-)Correlation Spectroscopy
Principal investigators: Algar, WRuss
Protein Glycosylation: Mechanisms and Consequences
Principal investigators: McIntosh, Lawrence
Investigating a biological specificity conundrum: the role of dynamics in transcription factor binding
Principal investigators: Scheu, Karlton
Keywords: Dna Binding; Electrophoretic Mobility Shift Assay; Next-Gen Sequencing; Nuclear Magnetic Resonance Spectroscopy; Protein Dynamics; Transcription Factors
Replacement of Life Sciences Institute Biomolecular Imager
Principal investigators: Jan, Eric
Operations and Maintenance Support: UBC Regional Structural Biology Facility
Principal investigators: McIntosh, Lawrence
Inhibitors of PNT domain polymerization as a novel therapy to target ETV6 chimeric oncoproteins
Principal investigators: Gerak, Chloe A
Keywords: Chemical Biology; Fragment-Based Drug Design; High-Throughput Screening; Isothermal Titration Calorimetry; Nuclear Magnetic Resonance Spectroscopy; Oncoprotein; Protein-Protein Interaction; Receptor Tyrosine Kinase; Structural Biology; Transcription Factor
Regulation of ETS Transcription Factors
Principal investigators: Mcintosh, Lawrence P
Keywords: Ets-Related Cancer; Nmr Spectroscopy; Phosphorylation; Post-Translational Modifications; Protein Structure-Function-Dynamics; Protein-Protein And -Dna Interactions; Signal Transduction; Structural Biology; Thermodynamics And Kinetics; Transcriptional Regulation
Analysing Macromolecular Binding at Biological Surfaces by Surface Plasmon Resonance
Principal investigators: Murphy, Michael
Dissecting the roles of DNA-binding autoinhibition, post-translational modification and protein partnerships in the regulation of the transcription factor ETV6 (or TEL)
Principal investigators: De, Soumya
Keywords: Autoinhibition; Biomolecular Structure; Drug Design; Isothermal Titration Calorimetry (Itc); Leukemia; Nmr Spectroscopy; Protein Dynamics; Protein-Dna Interaction; Transcription Factors; X-Ray Crystallography
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.