Faculty profile
Mahmoud Pouladi
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Research
Latest papers
Loss of interruption in the HTT CAG repeat is associated with somatic expansion and loss of medium spiny neurons in Huntington's disease.
Neuron · 2026
Latest funding
- $120,000
Genome Editing and Antisense Oligonucleotide mRNA Suppression as Therapy for CLDN11-Based Hypomyelinating Leukodystrophy 22
CIHR · 2025 · Supervisor
- $898,876
Probing the Role of Claudin-11 Mutations in Hypomyelinating Leukodystrophy
CIHR · 2024 · Nominated PI
- $120,000
Elucidating the Cellular and Molecular Role of Med15 Polymorphism in Huntington Disease Patient and Isogenic hiPSC-Derived Organoids and Medium Spiny Neurons
CIHR · 2024 · Supervisor
1 publications.
Loss of interruption in the HTT CAG repeat is associated with somatic expansion and loss of medium spiny neurons in Huntington's disease.
Kay C, Levesley J, Mätlik K, Findlay Black H, Harvey E, Bortnick S, Javier K, Buchanan C, Soomarooah T, Brás IC, Sequiera G, Pouladi M, Arning L, Nguyen HHP, Roxburgh R, Curtis M, Faull RLM, Heintz N, Hayden MR
Genome Editing and Antisense Oligonucleotide mRNA Suppression as Therapy for CLDN11-Based Hypomyelinating Leukodystrophy 22
Principal investigators: Gjervan, Sophia C
Keywords: Gene Therapy; Neurodegenerative Disease; Rare Diseases
Probing the Role of Claudin-11 Mutations in Hypomyelinating Leukodystrophy
Principal investigators: Pouladi, Mahmoud
Keywords: Claudin-11; Human Pluripotent Stem Cells; Hypomyelinating Leukodystrophy; Mouse Models; Neurodevelopmental Disorders; Therapeutics
Elucidating the Cellular and Molecular Role of Med15 Polymorphism in Huntington Disease Patient and Isogenic hiPSC-Derived Organoids and Medium Spiny Neurons
Principal investigators: McCallum, Ryan T
Keywords: Brain Organoids; Fibroblast Reprogramming; Hipsc-Derived Neurons; Htt; Huntington'S Disease; Med15; Mediator Complex; Neurodegeneration; Patient Tissue; Stem Cell Models Of Disease
Probing the Role of Claudin-11 Mutations in Hypomyelinating Leukodystrophy
Principal investigators: Pouladi, Mahmoud
Keywords: Claudin-11; Developmental Delay; Human Pluripotent Stem Cells; Hypomyelinating Leukodystrophy; Mouse Models; Neurodevelopmental Disorders; Therapeutics
Delineating the role of HTT Cis-Variants in the pathogenesis of Huntington disease, delCAA-HD, JPND2023-1822-096
Principal investigators: Pouladi, Mahmoud
Keywords: Animal Models; Genetic Analysis; Genetic Modifier; Human Pluripotent Stem Cells; Huntington'S Disease; Next Generation Sequencing; Transcriptomics
Deep Learning-Based Design of Synthetic Promoters for Oligodendroglia-Specific Expression
Principal investigators: Wasserman, Wyeth W
Keywords: Bioinformatics; Computational Biology; Gene Expression; Gene Therapy; Genome Regulation; Genomics; Regenerative Medicine; Stem Cell; Transcription Factors
Novel Approaches Directed to Prevention and Treatment of Huntington Disease
Principal investigators: Hayden, Michael R
Keywords: Animal Models; Drug Deliveries System; Excitotoxicity; Gene Silencing; Huntington Disease; Novel Pathways; Proteolysis
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
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