Faculty profile

Nobuhiko Tokuriki

ResearcherMichael Smith LaboratoriesUniversity of British Columbia

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of British Columbia directory, so their courses may be missing. Find their university profile.

Nobuhiko Tokuriki

Researcher

Michael Smith Laboratories

Health Sciences

University of British Columbia

Vancouver, British Columbia, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
19 publications in the last five years, latest in 2026.
Senior (last) author on 13 recent papers, a sign of leading a research group.
Principal investigator on 10 research grants (7 CIHR, 3 NSERC), most recently in 2025.
Supervised 1 trainee who won CIHR awards, most recently in 2024.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Antibiotic Resistance Experimental Evolution Beta-Lactamases Bioinformatics Biofilm Ancestral Reconstruction Bacterial Phenotyping Carbepenemases

Latest papers

Single-molecule kinetic exploration of functional sub-states in an evolving phosphotriesterase.
Nature communications · 2026 · senior author
Free energy perturbations in enzyme kinetic models reveal cryptic epistasis.
PLoS computational biology · 2026 · senior author
Widespread promiscuous alkaline phosphatases underscore ancient microbial phosphite utilization.
Proceedings of the National Academy of Sciences of the United States of America · 2025 · senior author

All 53 publications

Latest funding

A platform for developing rationally guided, broadly neutralizing antibodies for future pandemics, using SARS-CoV-2 as a model
CIHR · 2025 · Co-investigator
$1,147,500
A platform for developing rationally guided, broadly neutralizing antibodies for future pandemics, using SARS-CoV-2 as a model
CIHR · 2025 · Co-investigator
$100,000
Molecular and Evolutionary Mechanisms of Carbapenemases in Class A beta-Lactamase Family
CIHR · 2025 · Nominated PI
$1,071,000

All 16 grants and awards

53 publications.

Single-molecule kinetic exploration of functional sub-states in an evolving phosphotriesterase.

Sakuma M, Mahato DR, Feixas F, Jackson CJ, Nakata E, Osuna S, Tokuriki N

Nature communications2026Senior author

DOI: 10.1038/s41467-026-72534-1 PMID: 42067523

Free energy perturbations in enzyme kinetic models reveal cryptic epistasis.

Buda K, Tokuriki N

PLoS computational biology2026Senior author

DOI: 10.1371/journal.pcbi.1013493 PMID: 41811857

Widespread promiscuous alkaline phosphatases underscore ancient microbial phosphite utilization.

Sakuma M, Konno N, Gholipour S, Chen JZ, Tokuriki N

Proceedings of the National Academy of Sciences of the United States of America2025Senior author

DOI: 10.1073/pnas.2513042122 PMID: 41343678

Stability of multi-species consortia during microbial metabolic evolution.

Kehila D, Tafreshi AG, Tokuriki N

Evolution; international journal of organic evolution2025Senior author

DOI: 10.1093/evolut/qpaf141 PMID: 40622976

Functional sub-states link conformational landscapes and protein evolution.

Sakuma M, Buda K, Bunzel HA, Frøhlich C, Tokuriki N

Current opinion in structural biology2025Senior author

DOI: 10.1016/j.sbi.2025.103134 PMID: 40819485

Molecular Evolution and Origins of Antibiotic Resistance Genes.

Gholipour S, Lee D, Tokuriki N

Biochemistry2025Senior author

DOI: 10.1021/acs.biochem.5c00044 PMID: 40457171

Exploring Large Protein Sequence Space through Homology- and Representation-based Hierarchical Clustering.

Chen JZ, Gall B, Pulsford SB, Tokuriki N, Jackson CJ

Molecular biology and evolution2025

DOI: 10.1093/molbev/msaf136 PMID: 40465845

Computational and Experimental Exploration of Protein Fitness Landscapes: Navigating Smooth and Rugged Terrains.

Sandhu M, Chen JZ, Matthews DS, Spence MA, Pulsford SB, Gall B, Kaczmarski JA, Nichols J, Tokuriki N, Jackson CJ

Biochemistry2025

DOI: 10.1021/acs.biochem.4c00673 PMID: 40132127

Neutral drift upon threshold-like selection promotes variation in antibiotic resistance phenotype.

Erdoğan AN, Dasmeh P, Socha RD, Chen JZ, Life BE, Jun R, Kiritchkov L, Kehila D, Serohijos AWR, Tokuriki N

Nature communications2024Senior author

DOI: 10.1038/s41467-024-55012-4 PMID: 39737968

Increasing the Soluble Expression and Whole-Cell Activity of the Plastic-Degrading Enzyme MHETase through Consensus Design.

Saunders JW, Damry AM, Vongsouthi V, Spence MA, Frkic RL, Gomez C, Yates PA, Matthews DS, Tokuriki N, McLeod MD, Jackson CJ

Biochemistry2024

DOI: 10.1021/acs.biochem.4c00165 PMID: 38885634

A platform for developing rationally guided, broadly neutralizing antibodies for future pandemics, using SARS-CoV-2 as a model

Co-investigatorCIHR2025Project Grant

Principal investigators: Plotkin, Steven S

Keywords: Antigenic Escape; Broadly Neutralizing Antibodies; Deep Mutational Scanning; Genomics; Pandemic Preparedness; Pseudotyped Viruses; Rationally Designed Vaccines; Sars-Cov-2 Spike Protein; Structural Biology; Viral Evolution

$1,147,500

A platform for developing rationally guided, broadly neutralizing antibodies for future pandemics, using SARS-CoV-2 as a model

Co-investigatorCIHR2025Project Grant - PA: Pandemic Preparedness and Health Emergencies Research

Principal investigators: Plotkin, Steven S

$100,000

Molecular and Evolutionary Mechanisms of Carbapenemases in Class A beta-Lactamase Family

Nominated PICIHR2025Project Grant

Principal investigators: Tokuriki, Nobuhiko

Keywords: Ancestral Reconstruction; Antibiotic Resistance; Bacterial Phenotyping; Beta-Lactamases; Bioinformatics; Carbepenemases; High-Throughput Mutational Analysis

$1,071,000

Exploring and predicting high-functionality beta-lactamases and mechanisms of dissemination

SupervisorCIHR2024Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Lee, Dongkyu

Keywords: Antimicrobial Resistance; Beta-Lactamase; Direct Coupling Analysis; Dissemination Potential; High-Throughput Gene Synthesis; Next-Generation Sequencing; Predictive Modeling; Protein Evolution; Sequence-Function Relationship; Substrate Specificity

$120,000

A platform for developing mutation-resistant vaccines and antibodies for future viral variants, using SARS-CoV-2 as a model

Co-investigatorCIHR2023Project Gr. PA: Res. on Prevention/Response to Covid-19/Similar Future Pandemics

Principal investigators: Plotkin, Steven S

Keywords: Deep Mutational Scanning; Genomics; Mutational Escape; Pandemic Preparedness; Pseudotyped Viruses; Rationally Designed Antibodies; Rationally Designed Vaccines; Sars-Cov-2 Spike Protein; Structural Biology; Viral Evolution

Development of innovative strategies, tools, technologies, and methods for diagnostics and surveillance of antimicrobial resistance (DISTOMOS)

Nominated PICIHR2023Operating Grant: 16th JPIAMR transnational call for research projects (2023)

Principal investigators: Tokuriki, Nobuhiko

Keywords: Antibiotic Resistance; Antibiotic Resistance Survaillance; Bioinformatics; Gram Negative Pathogens; New Drug Resistance; Phenotypic Characterizations

$499,998

A development platform for mutation-resistant vaccines and antibodies for SARS-CoV-2 future variants

Co-investigatorCIHR2022Project Grant - PA: Pandemic Preparedness and Health Emergencies Research

Principal investigators: Plotkin, Steven S

Keywords: Deep Mutational Scanning; Genomics; Mutational Escape; Pseudotyped Viruses; Rationally Designed Antibodies; Rationally Designed Vaccines; Sars-Cov-2 Spike Protein; Structural Biology; Viral Evolution

$100,000

Comprehensive characterizations for the molecular and evolutionary mechanisms of beta-lactam 'resistome'

Nominated PICIHR2021Project Grant

Principal investigators: Tokuriki, Nobuhiko

Keywords: Antibiotic Resistance Genes; Antibiotics; Beta-Lactamase Inhibitors; Beta-Lactamases; Beta-Lactams; Comprehensive Bioinformatics; Deep Mutational Scanning; Experimental Evolution; High-Throughput Screening; Molecular Mechanisms

$1,032,750

Novel antibiotic therapies that target bacterial energetic systems

Nominated PICIHR2020Project Grant

Principal investigators: Tokuriki, Nobuhiko

Keywords: Antimicrobial Coating; Antimicrobial Resistance; Biofilm; Cellular Bioenergetics; Combination Therapy; Drug Repurposing; Microbial Evolution; Synergy

$956,250

The Canadian Integrative Consortium to Predict AMR Evolution (CIC-AMR)

Principal investigatorNSERC2019Discovery Frontiers - Antimicrobial Resistance

Principal investigators: Tokuriki, Nobuhiko

$10,800

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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