Orson Moritz

New animal models of retinal disease with retinal deposits

Principal investigators: Moritz, Orson L

Keywords: Abca4; Animal Models; Macular Degeneration; Pattern Dystrophy; Peripherin-2; Photoreceptors; Retinal Deposits; Retinal Disorders; Rpe65; Stargardt Disease

Genetic and environmental modulators of disease mechanisms in retinitis pigmentosa.

Principal investigators: Moritz, Orson L

Keywords: Gene-Environment Interaction; Genetic Interactions; Photoreceptors; Retinal Disorders; Retinitis Pigmentosa; Rhodopsin; Transgenics; Xenopus Laevis

Probing photoreceptor cell biology using genetically modified amphibians.

Principal investigators: Moritz, Orson

Super Resolution Core Facility Upgrade

Principal investigators: Nabi, Ivan

Mechanisms of cell death in inherited retinal degeneration caused by rhodopsin mutations

Principal investigators: Moritz, Orson L

Keywords: Confocal Microscopy; Pharmacological Chaperones; Photoreceptors; Retina; Retinal Degeneration; Retinitis Pigmentosa; Rhodopsin; Rods And Cones; Transgenics; Xenopus Laevis

Mechanisms of rod and cone disk membrane synthesis and quality control in normal and diseased retina.

Principal investigators: Moritz, Orson L

Keywords: Codon Bias; Disk Membranes; Er Quality Control; Photoreceptors; Protein Folding; Retinal Degeneration; Retinitis Pigmentosa; Rhodopsin; Rods And Cones; Transgenic Animals

Disk membrane synthesis in rod and cone photoreceptors

Principal investigators: Moritz, Orson

Gene Therapy for PAX6-Aniridia: Focusing on the Eye

Principal investigators: Simpson, Elizabeth M

Keywords: Adeno-Associated Virus (Aav); Cornea; Dna Binding Luciferase Induction; Ectopic Eye Induction In Xenopus Laevis; Gene Therapy (Gene-Based Protein Delivery); Human Congenital Disorder; Mouse Model Of Pax6-Aniridia Syndrome; Non Insertional; Ocular Aspects Of Aniridia; Pax6 Regulation By Microrna (Mirna) In Aav; Pax6 Regulation By Minipromoters In Aav; Pax6-Aniridia; Retina

CIHR Team in Novel molecular approaches in the treatment of retinal disease

Principal investigators: Gregory-Evans, Kevin; Gregory-Evans, Cheryl Y; Matsubara, Joanne A; Moritz, Orson L

Keywords: Animal Models; Cell Death; Gene Therapy; Neuroprotection; Retinal Disease; Treatment

In-vivo analysis of mechanisms of cell death in inherited retinal degeneration

Principal investigators: Moritz, Orson L

Keywords: Cell Death; Erad; Retinitis Pigmentosa; Rhodopsin; Trafficking; Transgenic Animals