This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of British Columbia directory, so their courses may be missing. Find their university profile.
Research
Latest papers
Rapid discovery of cell-surface glycosylation regulators using a lectin-based magnetic CRISPR screen.
Cell reports methods · 2026 · senior author
CRISPR activation screens map the genomic landscape of cancer glycome remodeling.
Cell genomics · 2026 · senior author
CRISPR screens to identify and characterize ligands for glycan-binding proteins.
Methods in enzymology · 2026 · senior author
Latest funding
- $120,000
GlycoMap: Identifying the oncogenic mutations that drive cancer glycome remodeling
CIHR · 2025 · Supervisor
- $1,036,576
Illuminating the functions of tumor associated carbohydrate antigens using next-generation screening technologies
CIHR · 2025 · Co-investigator
- $65,000
Targeting novel regulators of the CD44-hyaluronan axis to inhibit breast cancer metastasis
CIHR · 2024 · Nominated PI
13 publications.
Rapid discovery of cell-surface glycosylation regulators using a lectin-based magnetic CRISPR screen.
Kim J, Kovacs H, Wisnovsky S
CRISPR activation screens map the genomic landscape of cancer glycome remodeling.
Daly J, Piatnitca L, Al-Seragi M, Krishnamoorthy V, Wisnovsky S
CRISPR screens to identify and characterize ligands for glycan-binding proteins.
Kim J, Kovacs H, Wisnovsky S
Antibody-lectin chimeras for glyco-immune checkpoint blockade.
Stark JC, Gray MA, Ibarlucea-Benitez I, Lustig M, Bond A, Cho B, Govil I, Luu T, Priestley MJ, Veth TS, Errington WJ, Bruncsics B, Ribi MK, Williams LA, Sarkar CA, Wisnovsky S, Riley NM, Morrissey MA, Valerius T, Ravetch JV, Bertozzi CR
Polysialic acid is upregulated on activated immune cells and negatively regulates anticancer immune activity.
Drummond-Guy O, Daly J, Wu A, Stewart N, Milne K, Duff C, Nelson BH, Williams KC, Wisnovsky S
The glycosyltransferase ST3GAL4 drives immune evasion in acute myeloid leukemia by synthesizing ligands for the glyco-immune checkpoint receptor Siglec-9.
Krishnamoorthy V, Daly J, Kim J, Piatnitca L, Yuen KA, Kumar B, Taherzadeh Ghahfarrokhi M, Bui TQT, Azadi P, Vu LP, Wisnovsky S
The glycoimmune checkpoint receptor Siglec-7 interacts with T-cell ligands and regulates T-cell activation.
Stewart N, Daly J, Drummond-Guy O, Krishnamoorthy V, Stark JC, Riley NM, Williams KC, Bertozzi CR, Wisnovsky S
Elucidating the cellular determinants of targeted membrane protein degradation by lysosome-targeting chimeras.
Ahn G, Riley NM, Kamber RA, Wisnovsky S, Moncayo von Hase S, Bassik MC, Banik SM, Bertozzi CR
MYC-driven synthesis of Siglec ligands is a glycoimmune checkpoint.
Smith BAH, Deutzmann A, Correa KM, Delaveris CS, Dhanasekaran R, Dove CG, Sullivan DK, Wisnovsky S, Stark JC, Pluvinage JV, Swaminathan S, Riley NM, Rajan A, Majeti R, Felsher DW, Bertozzi CR
Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth.
Scott E, Hodgson K, Calle B, Turner H, Cheung K, Bermudez A, Marques FJG, Pye H, Yo EC, Islam K, Oo HZ, McClurg UL, Wilson L, Thomas H, Frame FM, Orozco-Moreno M, Bastian K, Arredondo HM, Roustan C, Gray MA, Kelly L, Tolson A, Mellor E, Hysenaj G, Goode EA, Garnham R, Duxfield A, Heavey S, Stopka-Farooqui U, Haider A, Freeman A, Singh S, Johnston EW, Punwani S, Knight B, McCullagh P, McGrath J, Crundwell M, Harries L, Bogdan D, Westaby D, Fowler G, Flohr P, Yuan W, Sharp A, de Bono J, Maitland NJ, Wisnovsky S, Bertozzi CR, Heer R, Guerrero RH, Daugaard M, Leivo J, Whitaker H, Pitteri S, Wang N, Elliott DJ, Schumann B, Munkley J
GlycoMap: Identifying the oncogenic mutations that drive cancer glycome remodeling
Principal investigators: Kovacs, Antal H
Keywords: Cancer Glycobiology; Crispr Screening; Tumour Immunology
Illuminating the functions of tumor associated carbohydrate antigens using next-generation screening technologies
Principal investigators: Edgar, Landon J
Keywords: Cancer Immunotherapy; Carbohydrate Chemistry; Crispra; Functional Genetics; Glycobiology; High-Parameter Flow Cytometry; Immunosuppression; Lectins; Lipid Nanoparticles; Unbiased Screening
Targeting novel regulators of the CD44-hyaluronan axis to inhibit breast cancer metastasis
Principal investigators: Wisnovsky, Simon
Keywords: Breast Cancer
T-cell glyco-immune checkpoints as next-generation targets for cancer immunotherapy
Principal investigators: Wisnovsky, Simon; Williams, Karla
Keywords: Carbohydrates; Glycans; Immune Checkpoint Receptors; Melanoma; Siglecs; T-Cells; Tumor Immunology
A systems glycobiology platform for revealing new immunotherapy targets in acute myeloid leukemia
Principal investigators: Wisnovsky, Simon
Keywords: Acute Myeloid Leukemia; Cancer Immunology; Crispr Screening; Functional Genomics; Glycan-Binding Receptors; Glycans; Glycomics; Innate Immune Checkpoints; Macrophages; Phagocytosis
Development of Genetic Screening Methods for Functional Characterization of Cell-Surface Glycans
Principal investigators: Wisnovsky, Simon
Development of Genetic Screening Methods for Functional Characterization of Cell-Surface Glycans
Principal investigators: Wisnovsky, Simon
Systematic characterization of glyco-immune signaling networks with high-throughput functional genomics
Principal investigators: Wisnovsky, Simon
Keywords: Carbohydrates; Crispr Screening; Functional Genomics; Glycans; Immune Cells; Immune Receptors; Immune Signalling; T Cells
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
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