Syam Somasekharan

Uncovering KNOP1 and TRiC/CCT-Mediated Pathways in Castration Resistant Prostate Cancer

Principal investigators: Yagnik, Unnati C

Keywords: Cancer Progression; Castration Resistant Prostate Cancer; Cell Proliferation; Chaperones; Lysine Rich Nucleolar Protein 1; Metastasis; Nucleolus; Prostate Cancer; Protein Folding; Therapeutic Target

Investigating the role of the RNA-binding protein DEAD box ATPase DDX55 in prostate cancer

Principal investigators: Cai, Ziwei

Keywords: Androgen Receptor; Cbp; Ddx55; Epithelial Mesenchymal Transition; Helicases; Invasion; Metastasis; Prostate Cancer; Prostate Cancer Treatment; Psa

Investigating the role of RNA-binding motif protein X-linked 2 (RBMX2) in nucleolar phase separation and functions

Principal investigators: Somasekharan, Syam

Investigating the role of RNA-binding motif protein X-linked 2 (RBMX2) in nucleolar phase separation and functions

Principal investigators: Somasekharan, Syam

Keywords: rbmx2; liquid-liquid phase separation; nuclear condensates; nucleolus; bimolecular condensates; liquid droplets; mrna translation; mass spectrometry; intrinsically disordered protein; chromatin remodelling

Characterizing the role of FKBP10 and eEF1A1 interaction in promoting translation elongation after proline insertion on early nascent chains

Principal investigators: Somasekharan, Syam S

Keywords: eEF1A1; FKBP10; mRNA translation; Polysomes; Proline codons; Ribosomes; RNA-binding proteins; RNA biology; Translational stalling; Translation elongation

Understanding epigenetic regulation and modulation of cell stress responses by the cholesterol transporter, scavenger receptor-B1 as a novel target for treating advanced prostate cancer

Principal investigators: Cox, Michael E; Wasan, Kishor M

Keywords: Cell Stress Pathways; Cholesterol; Epigenetics; Pharmacologic Inhibitors; Prostate Cancer; Scavenger Receptor-B1; Synthetic Lethal Screen; Therapy Resistance