Wilfred Jefferies

Leveraging tri-tissue transcriptomics to elucidate neurovascular pathophysiology in Alzheimer's Disease

Principal investigators: Johns, Kelly M

Keywords: Alzheimer'S Disease; Dementia; Drug Discovery; Human Pluripotent Stem Cells; Molecular Neurobiology; Mouse Models; Neural Organoids; Neuropharmacology; Single-Cell Sequencing; Transcriptomics

Accelerating Next-Generation Vaccine Development to Combat the Global Mpox Crisis

Principal investigators: Foster, Leonard J

Keywords: Hla; Infection Models; Mhc; Mpox; Self-Amplifying Dna; Self-Amplifying Rna; Vaccine

Development and Commercialization of a Safe and Effective Mpox Subunit Vaccine with Global Impact

Principal investigators: Foster, Leonard J

Keywords: Algorithm; Hla; Infection Models; Mhc; Mpox; Self-Amplifying Rna; Vaccine

Innovative Expression Platform for Therapeutic Antibody Delivery

Principal investigators: Foster, Leonard J

Keywords: Antibody Expression; Antibody Therapeutic; Malaria; Self-Amplifying Dna; Self-Amplifying Rna

Development and Commercialization of a Safe and Effective Mpox Subunit Vaccine with Global Impact

Principal investigators: Foster, Leonard J

Keywords: Algorithm; Hla; Infection Models; Mhc; Mpox; Self-Amplifying Rna; Vaccine

Structural determination of a 670 million year old iron-binding protein

Principal investigators: Jefferies, Wilfred

Studies on novel immune-surveillance mechanisms underlying cancer elimination

Principal investigators: Jefferies, Wilfred A

Keywords: Antigen Presentation; Eosinophil; Gene Regulation; Il-33; Immune Evasion; Metastasis; Mhc Class I; Mhc Class Ii; Mouse Model; Type 2 Innate Lymphocytes

Developing Technologies to Modulate Immunogenicity in Disease

Principal investigators: Jefferies, Wilfred A

Keywords: Antigen Presentation; Cross Presentation; Cytotoxic T Lymphocyte (Ctl); Dendritic Cell; High-Throughput Screen; Histone Deacetylase; Lmd/Pa; Mhc I; Prostate Cancer

CD74-Dependent MHC Class I Endolysosomal Cross-presentation Pathway

Principal investigators: Jefferies, Wilfred A

Keywords: Antigen Presentation; Cd74; Cross Presentation; Dendritic Cell; Invariant Chain; Mhc Class I; Mhc Class Ii; Mouse Model

Modulating Blood Vessel Growth in Alzheimer's Disease

Principal investigators: Jefferies, Wilfred A

Keywords: Alzheimer'S Disease; Angiogenesis; Anti-Angiogenic; Blood Brain Barrier; Inflammation; Microglia; Oxidative Radicals; Stroke; Tight Junctions; Tk Inhibitor