Brian Mark, University of Manitoba

Research

Beta-Hexosaminidase Blood Brain Barrier Enzyme Replacement Therapy Genome Editing Gm2 Gangliosidosis Lysosomal Storage Disease Pharmacological Chaperones Protein Engineering

Latest papers

Mutations in HYAL2, Encoding Hyaluronidase 2, Cause a Syndrome of Orofacial Clefting and Cor Triatriatum Sinister in Humans and Mice.
PLoS genetics · 2017

All 1 publications

Latest funding

Bioengineering plant resilience to viral infection
NSERC · 2020 · Principal investigator
$120,000
Bioengineering plant resilience to viral infection
NSERC · 2020 · Principal investigator
$252,000
Development of a therapeutic modality to treat GM2 gangliosidoses
CIHR · 2018 · Nominated PI
$547,740

All 15 grants and awards

1 publications.

01

Mutations in HYAL2, Encoding Hyaluronidase 2, Cause a Syndrome of Orofacial Clefting and Cor Triatriatum Sinister in Humans and Mice.

Muggenthaler MM, Chowdhury B, Hasan SN, Cross HE, Mark B, Harlalka GV, Patton MA, Ishida M, Behr ER, Sharma S, Zahka K, Faqeih E, Blakley B, Jackson M, Lees M, Dolinsky V, Cross L, Stanier P, Salter C, Baple EL, Alkuraya FS, Crosby AH, Triggs-Raine B, Chioza BA

PLoS genetics2017

DOI: 10.1371/journal.pgen.1006470 PMID: 28081210

Bioengineering plant resilience to viral infection

Principal investigatorNSERC2020Discovery Grants Program - Accelerator Supplements

Principal investigators: Mark, Brian

$120,000

Bioengineering plant resilience to viral infection

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Mark, Brian

$252,000

Development of a therapeutic modality to treat GM2 gangliosidoses

Nominated PICIHR2018Project Grant

Principal investigators: Mark, Brian L

Keywords: Beta-Hexosaminidase; Blood Brain Barrier; Enzyme Replacement Therapy; Genome Editing; Gm2 Gangliosidosis; Lysosomal Storage Disease; Pharmacological Chaperones; Protein Engineering; Sandhoff Disease; Tay-Sachs Disease

$547,740

Quasi-Elastic Light Scattering for in-depth protein and protein-complex characterization

Co-investigatorNSERC2018Research Tools and Instruments

Principal investigators: Stetefeld, JËrg

$43,671

Partners in Progress event

Principal investigatorNSERC2018Connect Grants Level 2

Principal investigators: Mark, Brian

$4,250

Ultraviolet (UV) light microscope for protein and nucleic acid crystal detection

Principal investigatorNSERC2017Research Tools and Instruments

Principal investigators: Mark, Brian

$110,702

Understanding the link between peptidoglycan recycling and beta-lactam antibiotic resistance in Gram negative bacteria

Nominated PICIHR2016Project Grant

Principal investigators: Mark, Brian L

Keywords: Ampc Beta-Lactamase; Antibiotic Resistance; Beta-Lactam; Chemical Biology; Chemical Synthesis; Drug Discovery; Microbiology; Peptidoglycan; Protein X-Ray Crystallography; Structural Biology

$760,680

Structural and mechanistic studies of multifunctional proteases in virus replication and host immune evasion

Principal investigatorNSERC2015Discovery Grants Program - Individual

Principal investigators: Mark, Brian

$225,000

Liquid handling system for protein crystallization

Principal investigatorNSERC2011Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Mark, Brian

$63,586

Microcalorimetric analysis of biomolecular interactions

Co-investigatorNSERC2011Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: McKenna, Sean

$85,964

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Vernon Dolinsky

Pharmacology and Therapeutics

1 shared papers, latest 2017

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Mention their NSERC grant from 2020

Subject: Prospective PhD student: Beta-Hexosaminidase Dear Professor Mark, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Mutations in HYAL2, Encoding Hyaluronidase 2, Cause a Syndrome of Orofacial Clefting and Cor Triatriatum Sinister in Humans and Mice." (2017), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Bioengineering plant resilience to viral infection" (2020), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]