James Davie

Transcriptionally active chromosomal domains

Principal investigators: Davie, James

Keywords: Chicken erythrocytes; Chromatin-associated proteins; Chromatin domains; Chromatin fractionation; Chromatin immunoprecipitation assay; Chromatin remodeling; Gene expression; Histone modifications; Imaging; Transcriptionally active chromatin

Investigating the molecular and cellular abnormalities of the brain in Rett Syndrome

Principal investigators: Rastegar, Mojgan

Keywords: Childhood Neurodevelopmental Disorders; Dna Methylation; Epigenetics; Genetics; Human Brain Tissues; Mechanism Of Disease; Metabolic Drugs; Pre-Clinical Studies; Rett Syndrome; Transgenic Mice

Investigating the molecular and cellular abnormalities of the brain in Rett Syndrome

Principal investigators: Rastegar, Mojgan

Keywords: Childhood Neurodevelopmental Disorders; Dna Methylation; Genetics; Human Brain Tissues; Mechanism Of Disease; Mecp2; Metabolic Drugs; Pre-Clinical Studies; Rett Syndrome; Transgenic Mice

Determine how the interaction between SARS-CoV-2 spike protein and angiotensin-converting enzyme 2 (ACE2) affect viral spread and the severity of COVID-19 outcomes.

Principal investigators: Su, Ruey-Chyi; Davie, James R

Keywords: Ace2 (Angiotensin-Converting Enzyme 2); Antiviral Response; Gene Regulation; Inflammation; Primary Human Cells; Sars-Cov-2 Spike Protein Variants

Targeted inhibition of DNA methyltransferase

Principal investigators: Lakowski, Ted

Keywords: Drug discovery Medicinal chemistry Biologic drugs Epigenetics Mass Spectrometry Gene expression Nanoparticle drug delivery DNA methylation Aptamers Gene and molecular therapy

Artificial Intelligence based adaptive and interpretable models for analyzing multi-track epigenomic sequential data

Principal investigators: Ashraf, Ahmed

Keywords: 3d Chromatin; 3d Genome; Artificial Intelligence; Deep Learning; Epigenetics; Machine Learning; Sequence Modeling

Oligonucleotide-bioconjugate mediated repression of the HOXA9 gene to treat mixed-lineage leukemia

Principal investigators: Lakowski, Ted M

Keywords: Drug Bio-Conjugation; Drug Development; Drug Discovery; Drug Targeting; Epigenetics; Histone Lysine Methyltransferase; Liquid Chromatography Tandem Mass Spectrometry; Post Translational Modifications

Histone arginine methylation and transcriptionally active chromosomal domains

Principal investigators: Davie, James

Protein arginine methyltransferases and transcriptionally active chromosomal domains

Principal investigators: Davie, James

The Developmental Origins of Obesity and Obesity-related Complications in Children

Principal investigators: Dolinsky, Vernon W; Davie, James R; Kobor, Michael S; Shen, Garry X; Wicklow, Brandy A

Keywords: Children'S Health; Diabetes; Epigenetics; Gene Expression; Maternal Health; Metabolism; Obesity; Pregnancy