Faculty profile
Kirk McManus
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Research
Latest papers
The steroid receptor RNA activator protein (SRAP) controls cancer cell migration/motility.
FEBS letters · 2015
Latest funding
- $1,208,700
Exploring and Targeting Reduced SKP2 Expression in Tubo-Ovarian High-Grade Serous Carcinoma.
CIHR · 2025 · Nominated PI
- $150,000
Urgent Need for an Automated High-Resolution Fluorescence Microscope (ARM) to Quantify Molecular Changes in Individual Cells
NSERC · 2024 · Co-investigator
- $55,000
Examining and charactering the impact ubiquitin homeostasis has on chromosome stability in higher eukaryotes
NSERC · 2024 · Principal investigator
1 publications.
The steroid receptor RNA activator protein (SRAP) controls cancer cell migration/motility.
Yan Y, Cooper C, Hamedani MK, Guppy B, Xu W, Tsuyuki D, Zhang C, Nugent Z, Blanchard A, Davie JR, McManus K, Murphy LC, Myal Y, Leygue E
Exploring and Targeting Reduced SKP2 Expression in Tubo-Ovarian High-Grade Serous Carcinoma.
Principal investigators: McManus, Kirk J
Keywords: Chromosome Instability (Cin); Crispr/Cas9; Health Outcomes Analyses; Precision Medicine; Quantitative Imaging Microscopy (Quantim); Scf Complex; Skp2; Synthetic Lethality; Tubo-Ovarian High-Grade Serous Carcinoma (Hgsc); Tumorigenesis/Oncogenesis
Urgent Need for an Automated High-Resolution Fluorescence Microscope (ARM) to Quantify Molecular Changes in Individual Cells
Principal investigators: Beattie, Robert
Keywords: Bright field microscopy; Cellular Heterogeneity; Dark field microscopy; Developmental Biology; Fluorescenece microscopy; Microscopy; Multimodal; Single Cell biology; Slide scanner; Stem cell biology
Examining and charactering the impact ubiquitin homeostasis has on chromosome stability in higher eukaryotes
Principal investigators: McManus, Kirk
Keywords: cellular & molecular biology; chromosome stability; chromosome biology & dynamics; crispr/cas9, crispri & rnai (si/shrna); genetics & cytogenetics; high-content imaging; mammalian tissue culture; mitotic fidelity; quantitative imaging microscopy (quantim); ubiquitin proteasome system
Exploring and Exploiting Reduced USP22 Expression in Colorectal Cancer
Principal investigators: McManus, Kirk J
Keywords: Bioinformatics; Cancer Genetics; Chromosome Instability; Colorectal Cancer; H2bub1; Mouse Models; Quantitative Imaging Microscopy; Single Cell Genomics (Copy Number Variation); Synthetic Lethality; Usp22
Identifying and functionally characterizing the molecular determinants of chromosome stability in higher eukaryotes
Principal investigators: McManus, Kirk
Identifying the Molecular Determinants of Chromosome Stability in Humans.
Principal investigators: McManus, Kirk
Characterizing and Targeting Diminished RNF20 Expression in Cancer
Principal investigators: McManus, Kirk J
Keywords: Cancer Genetics; Chromosome Instability; Cross-Species Approaches; High-Content Analysis; Novel Therapeutic Targets; Post-Translational Histone Modifications; Reverse Genetics; Rnf20; Synthetic Lethality; Tumorigenic Models
Molecular Basis of Interval Colorectal Cancers
Principal investigators: Singh, Harminder
Keywords: Colonoscopy; Colorectal Cancers
Determinants of Genome Stability and Drug Target Discovery
Principal investigators: McManus, Kirk J
Keywords: Cancer Genetics; Chromosome Instability; Genome Instability; High Content Imaging; Mammalian Tissue Culture; Synthetic Lethality
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
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