Lorrie Kirshenbaum

Research

Mitochondria Cardiac Myocytes Cell Death Gene Expression Molecular Biology Necrosis Hypoxia Autophagy

Latest papers

Cardiac arrhythmia in patients with inflammatory bowel disease: a retrospective, population-based cohort study in Manitoba, Canada.
BMJ open · 2025
The Role of Retinoic-Acid-Related Orphan Receptor (RORs) in Cellular Homeostasis.
International journal of molecular sciences · 2024
Ageing-associated increase in SGLT2 disrupts mitochondrial/sarcoplasmic reticulum Ca2+ homeostasis and promotes cardiac dysfunction.
Journal of cellular and molecular medicine · 2020

All 4 publications

Latest funding

Circadian Regulation of cell death in the heart
CIHR · 2026 · Supervisor
$6,000
Regulation of Cellular Quality Control Mechanisms in Doxorubicin Cardiomyopathy
CIHR · 2023 · Nominated PI
$757,350
Regulation of Programmed Necrosis in the Heart
CIHR · 2022 · Nominated PI
$1,101,600

All 17 grants and awards

4 publications.

01

Cardiac arrhythmia in patients with inflammatory bowel disease: a retrospective, population-based cohort study in Manitoba, Canada.

Narous M, Nugent Z, Rabinovich-Nikitin I, Kirshenbaum L, Bernstein CN

BMJ open2025

DOI: 10.1136/bmjopen-2024-097687 PMID: 40118486

02

The Role of Retinoic-Acid-Related Orphan Receptor (RORs) in Cellular Homeostasis.

Nematisouldaragh D, Kirshenbaum E, Uzonna M, Kirshenbaum L, Rabinovich-Nikitin I

International journal of molecular sciences2024

DOI: 10.3390/ijms252111340 PMID: 39518891

03

Ageing-associated increase in SGLT2 disrupts mitochondrial/sarcoplasmic reticulum Ca2+ homeostasis and promotes cardiac dysfunction.

Olgar Y, Tuncay E, Degirmenci S, Billur D, Dhingra R, Kirshenbaum L, Turan B

Journal of cellular and molecular medicine2020

DOI: 10.1111/jcmm.15483 PMID: 32652890

04

Cardiac Clocks and Preclinical Translation.

Mistry P, Duong A, Kirshenbaum L, Martino TA

Heart failure clinics2017

DOI: 10.1016/j.hfc.2017.05.002 PMID: 28865775

Circadian Regulation of cell death in the heart

SupervisorCIHR2026Undergraduate Student Research Awards (USRA)

Principal investigators: Uzonna, Michael

Keywords: Circadian Rhythms; Irregular Sleeping; Shift Workers

$6,000

Regulation of Cellular Quality Control Mechanisms in Doxorubicin Cardiomyopathy

Nominated PICIHR2023Project Grant

Principal investigators: Kirshenbaum, Lorrie A

Keywords: Autophagy; Cardiac Myocytes; Cell Death; Circadian; Clock; Gene Expression; Mitochondria; Molecular Biology; Necrosis

$757,350

Regulation of Programmed Necrosis in the Heart

Nominated PICIHR2022Project Grant

Principal investigators: Kirshenbaum, Lorrie A

Keywords: Cardiac Myocytes; Cell Death; Endoplasmic Reticulum; Mitochondria; Molecular Biology; Necrosis

$1,101,600

Circadian Dependent Regulation of Cardiac Cell Death

Nominated PICIHR2022Project Grant

Principal investigators: Kirshenbaum, Lorrie A

Keywords: Autophagy; Cardiac Myocytes; Circadian; Clock; Hypoxia; Mitochondria; Molecular Biology; Myocardial Infarction; Necrosis

$853,931

Integrated multi-omic delineation of SARS-CoV-2-dysregulated cellular processes

Co-investigatorCIHR2020Operating Grant: COVID-19 Rapid Research Funding Opportunity - Therapeutics

Principal investigators: Coombs, Kevin M

Keywords: Bioinformatics; Gene Silencing; Host Response; Proteomics

$790,162

Canada Research Chair - Tier 1

Nominated PICIHR2017Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Kirshenbaum, Lorrie A

Keywords: Crc

$1,400,000

Targeting Cell Death Signaling Pathways in the heart

SupervisorCIHR2016CIHR Fellowship

Principal investigators: Rabinovich-Nikitin, Inna

Keywords: Cardiac Cell Death; Cell Culture; Mitochondria; Ventricular Myocytes

$135,000

Targeting Cell Death Signaling Pathways in the Heart

Nominated PICIHR2015Operating Grant

Principal investigators: Kirshenbaum, Lorrie A

Keywords: Apoptosis; Cardiac Myocytes; Cell Death; Cell Signaling; Gene Expression; Hypoxia; Mitochondria

$569,850

Regulation of programmed cell death in the heart

Nominated PICIHR2015Foundation Grant

Principal investigators: Kirshenbaum, Lorrie A

Keywords: Cell Death; Gene Expression; Mitochondria; Molecular Biology; Necrosis; Ventricular Myocytes

$3,286,318

Molecular Determinants of Cell Death in the Heart

Nominated PICIHR2013Operating Grant

Principal investigators: Kirshenbaum, Lorrie A

Keywords: Cardiac Myocytes; Cell Culture; Cell Death; Gene Expression; Hypoxia; Mitochondria

$711,050

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Inna Rabinovich-Nikitin

Physiology and Pathophysiology

2 shared papers, latest 2025

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2023

Subject: Prospective PhD student: Mitochondria Dear Professor Kirshenbaum, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Cardiac arrhythmia in patients with inflammatory bowel disease: a retrospective, population-based cohort study in Manitoba, Canada." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Regulation of Cellular Quality Control Mechanisms in Doxorubicin Cardiomyopathy" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]