Laleh Alisaraie, Memorial University of Newfoundland

Research

Analysis of intermolecular interactions Atomic Force Microscopy Carbon nanotubes Force measurments In Silico study of microtubule Initial assembly Interaction of carbon nanotubes with microtubules and dynein In vitro evaluations Microtubles and Dynein

Latest papers

Investigating the Function of C‑Terminal Tails of Human Tubulin Isotypes in the Motility Regulation of Cytoplasmic Dynein.
ACS omega · 2026 · senior author
Dynein: A Multifaceted Therapeutic Target and Its Dysregulation in Aberrant Cell Proliferation.
Cytoskeleton (Hoboken, N.J.) · 2026 · senior author
Application of temperature replica exchange molecular dynamics: Structure of mitotic spindle-associated protein SHE1 and its binding to dynein.
Computational and structural biotechnology journal · 2025 · first author

All 14 publications

Latest funding

Biomechanics and Interrelations of Microtubules and Intracellular Trafficking: A Guide for Characterizing Carbon Nanotubes Cytotoxicity
NSERC · 2018 · Principal investigator
$192,000

All 1 grants and awards

14 publications.

01

Investigating the Function of C‑Terminal Tails of Human Tubulin Isotypes in the Motility Regulation of Cytoplasmic Dynein.

Garg J, Lopes Ribeiro J, Wallin S, Alisaraie L

ACS omega2026Senior author

DOI: 10.1021/acsomega.5c13203 PMID: 42179625

02

Dynein: A Multifaceted Therapeutic Target and Its Dysregulation in Aberrant Cell Proliferation.

Garg J, Alisaraie L

Cytoskeleton (Hoboken, N.J.)2026Senior author

DOI: 10.1002/cm.22041 PMID: 40417797

03

Application of temperature replica exchange molecular dynamics: Structure of mitotic spindle-associated protein SHE1 and its binding to dynein.

Alisaraie L, Stueker O, Tati S

Computational and structural biotechnology journal2025First author

DOI: 10.1016/j.csbj.2025.05.024 PMID: 40529183

04

ProS2Vi: A Python tool for visualizing proteins secondary structure.

Qasim ML, Alisaraie L

Computational and structural biotechnology journal2025Senior author

DOI: 10.1016/j.csbj.2025.02.038 PMID: 40160861

05

Recruitment of dynein and kinesin to viral particles.

Tati S, Alisaraie L

FASEB journal : official publication of the Federation of American Societies for Experimental Biology2022Senior author

DOI: 10.1096/fj.202101900rr PMID: 35471771

06

Analysis of the Structural Mechanism of ATP Inhibition at the AAA1 Subunit of Cytoplasmic Dynein-1 Using a Chemical "Toolkit".

Tati S, Alisaraie L

International journal of molecular sciences2021Senior author

DOI: 10.3390/ijms22147704 PMID: 34299323

07

C-terminal Tail of β-Tubulin and its Role in the Alterations of Dynein Binding Mode.

Heale KA, Alisaraie L

Cell biochemistry and biophysics2020Senior author

DOI: 10.1007/s12013-020-00920-7 PMID: 32462384

08

Interdomain twists of human thymidine phosphorylase and its active-inactive conformations: Binding of 5-FU and its analogues to human thymidine phosphorylase versus dihydropyrimidine dehydrogenase.

Tozer T, Heale K, Manto Chagas C, de Barros ALB, Alisaraie L

Chemical biology & drug design2019Senior author

DOI: 10.1111/cbdd.13596 PMID: 31356728

09

Metabolites of Vinca Alkaloid Vinblastine: Tubulin Binding and Activation of Nausea-Associated Receptors.

Chagas CM, Alisaraie L

ACS omega2019Senior author

DOI: 10.1021/acsomega.9b00652 PMID: 31460070

10

Drug metabolites and their effects on the development of adverse reactions: Revisiting Lipinski's Rule of Five.

Chagas CM, Moss S, Alisaraie L

International journal of pharmaceutics2018Senior author

DOI: 10.1016/j.ijpharm.2018.07.046 PMID: 30040971

Biomechanics and Interrelations of Microtubules and Intracellular Trafficking: A Guide for Characterizing Carbon Nanotubes Cytotoxicity

Principal investigatorNSERC2018Discovery Grants Program - Individual

Principal investigators: Alisaraie, Laleh

Keywords: Analysis of intermolecular interactions; Atomic Force Microscopy; Carbon nanotubes; Force measurments; In Silico study of microtubule Initial assembly; Interaction of carbon nanotubes with microtubules and dynein; In vitro evaluations; Microtubles and Dynein; Molecular dynamics simulations of dynein movements; Mutagenesis stuides

$192,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Stefan Wallin

Physics and Physical Oceanography

1 shared papers, latest 2026

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Applying for

Paper to mention

Subject: Prospective PhD student: Analysis of intermolecular interactions Dear Professor Alisaraie, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Investigating the Function of C‑Terminal Tails of Human Tubulin Isotypes in the Motility Regulation of Cytoplasmic Dynein." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Laleh Alisaraie