Denys Khaperskyy

Role of Nsp1-mediated general host shutoff in SARS-CoV-2 replication

Principal investigators: Khaperskyy, Denys

Keywords: Biochemistry; Molecular Virology; Protein-Rna Interactions; Sars-Cov-2; Viral Host Shutoff

Functional characterization of cross-reactive and specific antibodies against highly-pathogenic avian influenza at human/wildlife interface

Principal investigators: Khaperskyy, Denys

Keywords: Hpai

Open-label, phase 1/2, dose-escalation and dose-confirmation clinical trial to establish a Controlled Human Infection Model (CHIM) by determining and confirming the optimal, safe, and reproducible Influenza A:H3N2 dose administered intranasally to healthy adults 18-40 years of age that induces mild symptomatic infection and detection of Influenza A:H3N2 in nasal secretions by culture and/or PCR

Principal investigators: Halperin, Scott A; Ward, Brian J

Keywords: Challenge Study; Challenge Unit; Controlled Human Infection Model (Chim); Dose-Finding; Dose-Ranging; Healthy Adults; Influenza Virus; Pandemic Preparedness; Phase 1/2 Clinical Trial

Open-label, phase 1/2, dose-escalation and dose-confirmation clinical trial to establish a Controlled Human Infection Model (CHIM) by determining and confirming the optimal, safe, and reproducible Influenza A:H3N2 dose administered intranasally to healthy adults 18-40 years of age that induces mild symptomatic infection and detection of Influenza A:H3N2 in nasal secretions by culture and/or PCR

Principal investigators: Halperin, Scott A; Ward, Brian J

Keywords: Challenge Study; Challenge Unit; Controlled Human Infection Model (Chim); Dose-Finding; Dose-Ranging; Healthy Adults; Influenza Virus; Pandemic Preparedness; Phase 1/2 Clinical Trial

Molecular mechanisms of host shutoff by respiratory viruses and their contribution to viral pathogenesis

Principal investigators: Khaperskyy, Denys

Keywords: Coronavirus; Host Shutoff; Influenza Virus; Innate Immune Responses; Non-Structural Protein 1 (Ns1); Non-Structural Protein 1 (Nsp1); Polymerase Acidic Protein X (Pa-X); Protein-Protein Interactions

High-throughput single-cell imaging flow cytometry platform

Principal investigators: Cheng, Zhenyu

Functional characterisation of stress granule composition and morphology

Principal investigators: Khaperskyy, Denys

Functional characterisation of stress granule composition and morphology

Principal investigators: Khaperskyy, Denys

Discovery and Preclinical Development of Novel Stress Granule-Inducing Antiviral Drugs

Principal investigators: McCormick, Craig

Keywords: Antiviral Drug; Commercialization; Drug Resistance; Evolution; Influenza; Mechanism Of Action; Rna; Stress Granule; Translation; Virus