Patrick Lee, Dalhousie University

Research

Anti-Cancer Immunity Reovirus Apoptosis Dna Damage Nmnat2 P53 Cancer Innnate Immunity

Latest papers

Potentiating prostate cancer immunotherapy with oncolytic viruses.
Nature reviews. Urology · 2018 · first author
Sharpening the Edge for Precision Cancer Immunotherapy: Targeting Tumor Antigens through Oncolytic Vaccines.
Frontiers in immunology · 2017
Cell surface protease activation during RAS transformation: Critical role of the plasminogen receptor, S100A10.
Oncotarget · 2016

All 3 publications

Latest funding

Virus-induced Tumor MHC Ligandome Discovery for Cancer Immunotherapy
CIHR · 2016 · Supervisor
$105,000
The role of NMNAT2, a new p53 target gene, in feedback regulation of p53 function via the SIRT deacetylases.
CIHR · 2015 · Nominated PI
$570,028
Role of NAMPT/NMNATs-SIRTs-tumor suppressor proteins nexus in breast cancer
CIHR · 2015 · Supervisor
$75,000

All 12 grants and awards

3 publications.

01

Potentiating prostate cancer immunotherapy with oncolytic viruses.

Lee P, Gujar S

Nature reviews. Urology2018First author

DOI: 10.1038/nrurol.2018.10 PMID: 29434366

02

Sharpening the Edge for Precision Cancer Immunotherapy: Targeting Tumor Antigens through Oncolytic Vaccines.

Holay N, Kim Y, Lee P, Gujar S

Frontiers in immunology2017

DOI: 10.3389/fimmu.2017.00800 PMID: 28751892

03

Cell surface protease activation during RAS transformation: Critical role of the plasminogen receptor, S100A10.

Madureira PA, Bharadwaj AG, Bydoun M, Garant K, O'Connell P, Lee P, Waisman DM

Oncotarget2016

DOI: 10.18632/oncotarget.10279 PMID: 27351226

Virus-induced Tumor MHC Ligandome Discovery for Cancer Immunotherapy

SupervisorCIHR2016Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Kim, Youra

Keywords: Anti-Tumor Immunity; Anti-Viral Immunity; Immunotherapy; Mass Spectrometry; Mhc Ligandome; Oncolytic Virus; T Cell Immunity; Virotherapy

$105,000

The role of NMNAT2, a new p53 target gene, in feedback regulation of p53 function via the SIRT deacetylases.

Nominated PICIHR2015Operating Grant

Principal investigators: Lee, Patrick W

Keywords: Apoptosis; Cancer; Dna Damage; Nmnat2; P53; Sirt

$570,028

Role of NAMPT/NMNATs-SIRTs-tumor suppressor proteins nexus in breast cancer

SupervisorCIHR2015CIHR Fellowship

Principal investigators: Sharif, Tanveer

Keywords: 2 & 3); Breast Cancer; Nad+ Salvage Pathway; Nampt; Nmnats (1; Sirtuins; Tumor Suppressor Proteins

$75,000

SexImmunome of Virus-assisted Cancer Immunotherapy: Discovery, Characterization and Therapeutic Implications

Nominated PICIHR2015Catalyst Grant: Sex as a Variable in Biomedical Research

Principal investigators: Lee, Patrick W

Keywords: Cancer; Immunotherapy; Sex As A Variable; Virus

$150,000

The role of NMNAT2, a new p53 target gene, in feedback regulation of p53 function via the SIRT deacetylases.

Nominated PICIHR2014Operating Grant

Principal investigators: Lee, Patrick W

Keywords: Apoptosis; Dna Damage; Nmnat2; P53

$100,000

Enhancing the therapeutic potential of reovirus oncotherapy through the characterization and manipulation of myeloid-derived suppressor cells

SupervisorCIHR2014Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Clements, Derek R

Keywords: Immunology Of Cancer; Immunosuppression; Virotherapy

$105,000

Reovirus-induced immune modulation during oncotherapy

Nominated PICIHR2013Operating Grant

Principal investigators: Lee, Patrick W

Keywords: Anti-Cancer Immunity; Reovirus

$725,730

Molecular and immunological characterizations of reovirus oncolysis

Nominated PICIHR2012Operating Grant - PA: Regional Partnership Program - Nova Scotia

Principal investigators: Lee, Patrick W

Keywords: Anti-Cancer Immunity; Innnate Immunity; Ras Signalling; Reovirus

$8,778

Molecular and immunological characterizations of reovirus oncolysis

Nominated PICIHR2012Operating Grant - Priority Announcement: Infection and Immunity (Bridge Funding)

Principal investigators: Lee, Patrick W

Keywords: Anti-Cancer Immunity; Innnate Immunity; Ras Signalling; Reovirus

$100,000

Save the Virus, Kill the Cancer: Selective Inhibition of Anti-Viral Immune Response to Establish Anti-Tumor Immunity and Complete Cancer Regression

SupervisorCIHR2010CIHR Fellowship

Principal investigators: Gujar, Shashi A

Keywords: Antigen-Specific Immunomodulation; Immunotherapy Of Cancer; Killer Dendritic Cells; Virotherapy

$135,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Shashi Gujar

Pathology

2 shared papers, latest 2018

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Subject: Prospective PhD student: Anti-Cancer Immunity Dear Professor Lee, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Potentiating prostate cancer immunotherapy with oncolytic viruses." (2018), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]