Paul Linsdell, Dalhousie University

Research

Abc Proteins Cystic Fibrosis Disulfide Cross-Linking Electrophysiology Ion Channels Membrane Proteins Patch Clamp Site-Directed Mutagenesis

Latest papers

Trivalent anions as probes of the CFTR channel pore.
General physiology and biophysics · 2024 · first author
Correction: Role of Hydrophobic Amino-Acid Side-Chains in the Narrow Selectivity Filter of the CFTR Chloride Channel Pore in Conductance and Selectivity.
The Journal of membrane biology · 2024 · first author
Role of Hydrophobic Amino-Acid Side-Chains in the Narrow Selectivity Filter of the CFTR Chloride Channel Pore in Conductance and Selectivity.
The Journal of membrane biology · 2023 · first author

All 62 publications

Latest funding

Mechanism of Chloride Conduction in the CFTR Anion Channel
NSERC · 2017 · Principal investigator
$156,000
Conformational changes opening and closing the CFTR chloride channel
CIHR · 2015 · Nominated PI
$100,000
Functional Architecture of the CFTR Chloride Channel
CIHR · 2009 · Nominated PI
$754,385

All 4 grants and awards

62 publications.

01

Trivalent anions as probes of the CFTR channel pore.

Linsdell P

General physiology and biophysics2024First author

DOI: 10.4149/gpb_2024007 PMID: 38774920

02

Correction: Role of Hydrophobic Amino-Acid Side-Chains in the Narrow Selectivity Filter of the CFTR Chloride Channel Pore in Conductance and Selectivity.

Linsdell P

The Journal of membrane biology2024First author

DOI: 10.1007/s00232-023-00304-x PMID: 38244069

03

Role of Hydrophobic Amino-Acid Side-Chains in the Narrow Selectivity Filter of the CFTR Chloride Channel Pore in Conductance and Selectivity.

Linsdell P

The Journal of membrane biology2023First author

DOI: 10.1007/s00232-023-00294-w PMID: 37823914

04

Molecular dynamics study of Cl- permeation through cystic fibrosis transmembrane conductance regulator (CFTR).

Zeng ZW, Linsdell P, Pomès R

Cellular and molecular life sciences : CMLS2023

DOI: 10.1007/s00018-022-04621-7 PMID: 36694009

05

Functionally additive fixed positive and negative charges in the CFTR channel pore control anion binding and conductance.

Linsdell P, Irving CL, Cowley EA

The Journal of biological chemistry2022First author

DOI: 10.1016/j.jbc.2022.101659 PMID: 35101441

06

Monovalent: Divalent Anion Selectivity in the CFTR Channel Pore.

Linsdell P

Cell biochemistry and biophysics2021First author

DOI: 10.1007/s12013-021-00998-7 PMID: 34031860

07

Two positively charged amino acid side-chains in the inner vestibule of the CFTR channel pore play analogous roles in controlling anion binding and anion conductance.

Linsdell P, Irving CL, Cowley EA, El Hiani Y

Cellular and molecular life sciences : CMLS2021First author

DOI: 10.1007/s00018-021-03859-x PMID: 34023918

08

On the relationship between anion binding and chloride conductance in the CFTR anion channel.

Linsdell P

Biochimica et biophysica acta. Biomembranes2021First author

DOI: 10.1016/j.bbamem.2021.183558 PMID: 33444622

09

Electrostatic Tuning of Anion Attraction from the Cytoplasm to the Pore of the CFTR Chloride Channel.

Linsdell P, Negoda A, Cowley EA, El Hiani Y

Cell biochemistry and biophysics2020First author

DOI: 10.1007/s12013-019-00899-w PMID: 31893350

10

Contribution of the eighth transmembrane segment to the function of the CFTR chloride channel pore.

Negoda A, Hogan MS, Cowley EA, Linsdell P

Cellular and molecular life sciences : CMLS2019Senior author

DOI: 10.1007/s00018-019-03043-2 PMID: 30758641

Mechanism of Chloride Conduction in the CFTR Anion Channel

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Linsdell, Paul

$156,000

Conformational changes opening and closing the CFTR chloride channel

Nominated PICIHR2015Operating Grant

Principal investigators: Linsdell, Paul

Keywords: Abc Proteins; Cystic Fibrosis; Disulfide Cross-Linking; Electrophysiology; Ion Channels; Membrane Proteins; Patch Clamp; Site-Directed Mutagenesis; Structure-Function Relationships

$100,000

Functional Architecture of the CFTR Chloride Channel

Nominated PICIHR2009Operating Grant

Principal investigators: Linsdell, Paul

Keywords: Cystic Fibrosis; Electrophysiology; Ion Channels; Patch Clamp; Site-Directed Mutagenesis; Structure-Function Relationships

$754,385

Planar lipid bilayer workstation for peptide ion channel research

Principal investigatorNSERC2003Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Linsdell, Paul

$42,229

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Subject: Prospective PhD student: Abc Proteins Dear Professor Linsdell, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Trivalent anions as probes of the CFTR channel pore." (2024), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Paul Linsdell

Research

Latest papers

Latest funding

Trivalent anions as probes of the CFTR channel pore.

Correction: Role of Hydrophobic Amino-Acid Side-Chains in the Narrow Selectivity Filter of the CFTR Chloride Channel Pore in Conductance and Selectivity.

Role of Hydrophobic Amino-Acid Side-Chains in the Narrow Selectivity Filter of the CFTR Chloride Channel Pore in Conductance and Selectivity.

Molecular dynamics study of Cl- permeation through cystic fibrosis transmembrane conductance regulator (CFTR).

Functionally additive fixed positive and negative charges in&#xa0;the CFTR channel pore control anion binding and conductance.

Monovalent: Divalent Anion Selectivity in the CFTR Channel Pore.

Two positively charged amino acid side-chains in the inner vestibule of the CFTR channel pore play analogous roles in controlling anion binding and anion conductance.

On the relationship between anion binding and chloride conductance in the CFTR anion channel.

Electrostatic Tuning of Anion Attraction from the Cytoplasm to the Pore of the CFTR Chloride Channel.

Contribution of the eighth transmembrane segment to the function of the CFTR chloride channel pore.

Mechanism of Chloride Conduction in the CFTR Anion Channel

Conformational changes opening and closing the CFTR chloride channel

Functional Architecture of the CFTR Chloride Channel

Planar lipid bilayer workstation for peptide ion channel research

Functionally additive fixed positive and negative charges in the CFTR channel pore control anion binding and conductance.