This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Carleton University directory, so their courses may be missing. Find their university profile.
Research
Latest papers
In vitro modulation of mTOR and mGlur5 influence α-synuclein accumulation.
Molecular brain · 2024
Placental Remote Control of Fetal Metabolism: Trophoblast mTOR Signaling Regulates Liver IGFBP-1 Phosphorylation and IGF-1 Bioavailability.
International journal of molecular sciences · 2023
TWIST1 methylation by SETD6 selectively antagonizes LINC-PINT expression in glioma.
Nucleic acids research · 2022
Latest funding
- $134,771
Updated Peptide Synthesis Infrastructure for the Carleton University Functional Proteomics Facility
NSERC · 2024 · Principal investigator
- $80,000
Systematic discovery and functional characterization of non-histone substrates for the KDM5 family of lysine demethylase enzymes
NSERC · 2023 · Principal investigator
- $20,000
Lab2Market: A novel strategy towards the computational development of peptide 'disruptors' to be used as molecular probes or therapeutic molecules.
NSERC · 2022 · Principal investigator
11 publications.
In vitro modulation of mTOR and mGlur5 influence α-synuclein accumulation.
Xing V, Biggar K, Ferguson SSG, Hayley S
Placental Remote Control of Fetal Metabolism: Trophoblast mTOR Signaling Regulates Liver IGFBP-1 Phosphorylation and IGF-1 Bioavailability.
Rosario FJ, Chopra A, Biggar K, Powell TL, Gupta MB, Jansson T
TWIST1 methylation by SETD6 selectively antagonizes LINC-PINT expression in glioma.
Admoni-Elisha L, Elbaz T, Chopra A, Shapira G, Bedford MT, Fry CJ, Shomron N, Biggar K, Feldman M, Levy D
IGFBP-1 hyperphosphorylation in response to nutrient deprivation is mediated by activation of protein kinase Cα (PKCα).
Chen AW, Biggar K, Nygard K, Singal S, Zhao T, Li C, Nathanielsz PW, Jansson T, Gupta MB
Mechanistic Target of Rapamycin Complex 1 Signaling Links Hypoxia to Increased IGFBP-1 Phosphorylation in Primary Human Decidualized Endometrial Stromal Cells.
Nandi P, Jang CE, Biggar K, Halari CD, Jansson T, Gupta MB
Mechanisms linking hypoxia to phosphorylation of insulin-like growth factor binding protein-1 in baboon fetuses with intrauterine growth restriction and in cell culture.
Kakadia J, Biggar K, Jain B, Chen AW, Nygard K, Li C, Nathanielsz PW, Jansson T, Gupta MB
Hyperphosphorylation of fetal liver IGFBP-1 precedes slowing of fetal growth in nutrient-restricted baboons and may be a mechanism underlying IUGR.
Kakadia JH, Jain BB, Biggar K, Sutherland A, Nygard K, Li C, Nathanielsz PW, Jansson T, Gupta MB
Inhibition of decidual IGF-1 signaling in response to hypoxia and leucine deprivation is mediated by mTOR and AAR pathways and increased IGFBP-1 phosphorylation.
Abu Shehab M, Biggar K, Kakadia JH, Dhruv M, Jain B, Nandi P, Nygard K, Jansson T, Gupta MB
IUGR Is Associated With Marked Hyperphosphorylation of Decidual and Maternal Plasma IGFBP-1.
Gupta MB, Abu Shehab M, Nygard K, Biggar K, Singal SS, Santoro N, Powell TL, Jansson T
Co-Localization of Insulin-Like Growth Factor Binding Protein-1, Casein Kinase-2β, and Mechanistic Target of Rapamycin in Human Hepatocellular Carcinoma Cells as Demonstrated by Dual Immunofluorescence and in Situ Proximity Ligation Assay.
Singal SS, Nygard K, Dhruv MR, Biggar K, Shehab MA, Li SS, Jansson T, Gupta MB
Updated Peptide Synthesis Infrastructure for the Carleton University Functional Proteomics Facility
Principal investigators: Biggar, Kyle
Keywords: Functional proteomics; Machine learning data generation; Peptide array; Peptide-protein interaction; Peptide synthesis; Post-translational modification
Systematic discovery and functional characterization of non-histone substrates for the KDM5 family of lysine demethylase enzymes
Principal investigators: Biggar, Kyle
Keywords: lysine methylation; lysine demethylase; protein post-translational modification; enzyme; non-histone protein methylation; p53 methylation; kdm5
Lab2Market: A novel strategy towards the computational development of peptide 'disruptors' to be used as molecular probes or therapeutic molecules.
Principal investigators: Biggar, Kyle
Updated Infrastructure for the Carleton University Biomolecular Radiation Facility
Principal investigators: Bruin, Jennifer
Systematic development of novel peptide-derived inhibitors for methyl-regulatory enzymes
Principal investigators: Biggar, Kyle
COVID-19: Annotating and controlling the inter-species protein interactome through the development of peptide inhibitors for SARS-CoV-2 and human protein interactions_x000d_ _x000d_ _x000d_
Principal investigators: Biggar, Kyle
Hypoxic workstation to conduct studies in low oxygen environments
Principal investigators: Willmore, William
Discovery and functional characterization of the hypoxia-responsive methyllysine proteome
Principal investigators: Biggar, Kyle
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
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