Faculty profile

Stefan Siemann

ResearcherChemistry and BiochemistryLaurentian University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Laurentian University directory, so their courses may be missing. Find their university profile.

Stefan Siemann

Researcher

Chemistry and Biochemistry

Laurentian University

Sudbury, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
4 publications in the last five years, latest in 2025.
Senior (last) author on 4 recent papers, a sign of leading a research group.
Principal investigator on 5 research grants (5 NSERC), most recently in 2018.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Publications

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Anthrax lethal factor Bioinorganic Chemistry Enzyme mechanism Enzymology Metal exchange Metalloproteins Metal substitution Spectroscopies

Latest papers

Simulation of absorption spectra of native and unfolded proteins.
Analytical biochemistry · 2025 · senior author
Accessibility of Carboxypeptidase A-bound Zinc to Chelation Correlates with an Intermediate State in the Protein's Unfolding Pathway.
Biochemistry · 2025 · senior author
Removal of Metal from Carboxypeptidase A Proceeds via a Split Pathway: Implications for the General Mechanisms of Metalloenzyme Inactivation by Chelating Agents.
Biochemistry · 2024 · senior author

All 22 publications

Latest funding

Carbapenemase inhibitors for use as adjuvants in treating carbapenem-resistant bacterial infections
CIHR · 2019 · Co-investigator
$673,200
Metal requirement and mechanism of anthrax lethal factor and other zinc proteases
NSERC · 2018 · Principal investigator
$174,000
Mechanism and Inhibition of Anthrax Lethal Factor
NSERC · 2013 · Principal investigator
$170,000

All 9 grants and awards

22 publications.

Simulation of absorption spectra of native and unfolded proteins.

Pilkington TJ, Siemann S

Analytical biochemistry2025Senior author

DOI: 10.1016/j.ab.2025.115803 PMID: 39952312

Accessibility of Carboxypeptidase A-bound Zinc to Chelation Correlates with an Intermediate State in the Protein's Unfolding Pathway.

Goulet DL, Bignucolo MW, Siemann S

Biochemistry2025Senior author

DOI: 10.1021/acs.biochem.4c00517 PMID: 40059844

Removal of Metal from Carboxypeptidase A Proceeds via a Split Pathway: Implications for the General Mechanisms of Metalloenzyme Inactivation by Chelating Agents.

Bignucolo MW, Siemann S

Biochemistry2024Senior author

DOI: 10.1021/acs.biochem.4c00272 PMID: 39046854

An Excel fitting routine for correcting protein absorption spectra for scatter.

Pilkington TJ, Bignucolo MW, Ainsworth JP, Siemann S

Analytical biochemistry2023Senior author

DOI: 10.1016/j.ab.2023.115269 PMID: 37543276

Effect of pH and denaturants on the fold and metal status of anthrax lethal factor.

Lo SY, Goulet DL, Fraaz U, Siemann S

Archives of biochemistry and biophysics2020Senior author

DOI: 10.1016/j.abb.2020.108547 PMID: 32828796

Specificity-directed design of a FRET-quenched heptapeptide for assaying thermolysin-like proteases.

Goulet DL, Fraaz U, Zulich CJ, Pilkington TJ, Siemann S

Analytical biochemistry2020Senior author

DOI: 10.1016/j.ab.2020.113826 PMID: 32622975

Binding of Cu, Co, and Cs to fluorescent components of natural organic matter (NOM) from three contrasting sites.

Hume S, Caron F, Siemann S

Environmental science and pollution research international2018Senior author

DOI: 10.1007/s11356-018-2181-1 PMID: 29748802

An investigation of the pH dependence of copper-substituted anthrax lethal factor and its mechanistic implications.

Young CJ, Richard K, Beruar A, Lo SY, Siemann S

Journal of inorganic biochemistry2018Senior author

DOI: 10.1016/j.jinorgbio.2018.01.015 PMID: 29407865

Structural and Kinetic Studies of the Potent Inhibition of Metallo-β-lactamases by 6-Phosphonomethylpyridine-2-carboxylates.

Hinchliffe P, Tanner CA, Krismanich AP, Labbé G, Goodfellow VJ, Marrone L, Desoky AY, Calvopiña K, Whittle EE, Zeng F, Avison MB, Bols NC, Siemann S, Spencer J, Dmitrienko GI

Biochemistry2018

DOI: 10.1021/acs.biochem.7b01299 PMID: 29485857

Highly dynamic metal exchange in anthrax lethal factor involves the occupation of an inhibitory metal binding site.

Young CJ, Siemann S

Chemical communications (Cambridge, England)2016Senior author

DOI: 10.1039/c6cc05460a PMID: 27517100

Carbapenemase inhibitors for use as adjuvants in treating carbapenem-resistant bacterial infections

Co-investigatorCIHR2019Project Grant

Principal investigators: Dmitrienko, Gary I

Keywords: Antibiotics; Enzyme Inhibitors; Enzymology; Medicinal Chemistry; Microbiology; Molecular Modelling; Organic Synthesis

$673,200

Metal requirement and mechanism of anthrax lethal factor and other zinc proteases

Principal investigatorNSERC2018Discovery Grants Program - Individual

Principal investigators: Siemann, Stefan

Keywords: Anthrax lethal factor; Bioinorganic Chemistry; Enzyme mechanism; Enzymology; Metal exchange; Metalloproteins; Metal substitution; Spectroscopies; Zinc proteases

$174,000

Mechanism and Inhibition of Anthrax Lethal Factor

Principal investigatorNSERC2013Discovery Grants Program - Individual

Principal investigators: Siemann, Stefan

$170,000

Canada-UK Team in Bacterial Resistance to Beta-Lactam Antibiotics

Co-investigatorCIHR2011Canada-UK Partnership on Antibiotic Resistance

Principal investigators: Dmitrienko, Gary I; Lubell, William D

Keywords: Antibiotic Resistance

$1,977,900

Mechanism/inibition of anthrax lethal factor and development of optical anion chemosensors

Principal investigatorNSERC2010Discovery Grants Program - Individual

Principal investigators: Siemann, Stefan

$27,000

Tabletop ultracentrifuge

Co-investigatorNSERC2007Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Gauthier, Eric

$57,863

FPLC protein purification system

Co-investigatorNSERC2006Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Gauthier, Eric

$85,943

Role of metal ions in the catalytic mechanism of anthrax lethal factor

Principal investigatorNSERC2005Discovery Grants Program - Individual

Principal investigators: Siemann, Stefan

$66,000

Protein production facility for the isolation of anthrax lethal factor

Principal investigatorNSERC2005Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Siemann, Stefan

$74,119

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Stefan Siemann

Research

Latest papers

Latest funding

Simulation of absorption spectra of native and unfolded proteins.

Accessibility of Carboxypeptidase A-bound Zinc to Chelation Correlates with an Intermediate State in the Protein's Unfolding Pathway.

Removal of Metal from Carboxypeptidase A Proceeds via a Split Pathway: Implications for the General Mechanisms of Metalloenzyme Inactivation by Chelating Agents.

An Excel fitting routine for correcting protein absorption spectra for scatter.

Effect of pH and denaturants on the fold and metal status of anthrax lethal factor.

Specificity-directed design of a FRET-quenched heptapeptide for assaying thermolysin-like proteases.

Binding of Cu, Co, and Cs to fluorescent components of natural organic matter (NOM) from three contrasting sites.

An investigation of the pH dependence of copper-substituted anthrax lethal factor and its mechanistic implications.

Structural and Kinetic Studies of the Potent Inhibition of Metallo-&#x3b2;-lactamases by 6-Phosphonomethylpyridine-2-carboxylates.

Highly dynamic metal exchange in anthrax lethal factor involves the occupation of an inhibitory metal binding site.

Carbapenemase inhibitors for use as adjuvants in treating carbapenem-resistant bacterial infections

Metal requirement and mechanism of anthrax lethal factor and other zinc proteases

Mechanism and Inhibition of Anthrax Lethal Factor

Canada-UK Team in Bacterial Resistance to Beta-Lactam Antibiotics

Mechanism/inibition of anthrax lethal factor and development of optical anion chemosensors

Tabletop ultracentrifuge

FPLC protein purification system

Role of metal ions in the catalytic mechanism of anthrax lethal factor

Protein production facility for the isolation of anthrax lethal factor

Structural and Kinetic Studies of the Potent Inhibition of Metallo-β-lactamases by 6-Phosphonomethylpyridine-2-carboxylates.