Aaron Schimmer, University of Guelph

Research

Acute Myeloid Leukemia Drug Discovery In Vivo/In Vitro Biological Assays Medicinal Chemistry Mitochondrial Matrix Proteases Structural Biology

Latest funding

Developing allosteric inhibitors of mitochondrial ClpP protease for acute myeloid leukemia
CIHR · 2023 · Principal investigator
$1,143,675
Development of boron-based inhibitors of the mitochondrial ClpXP protease to combat AML
CIHR · 2022 · Co-investigator
$100,000

All 2 grants and awards

Developing allosteric inhibitors of mitochondrial ClpP protease for acute myeloid leukemia

Principal investigatorCIHR2023Project Grant

Principal investigators: Vahidi, Siavash; Schimmer, Aaron D; Zeytuni, Natalie

Keywords: Acute Myeloid Leukemia; Drug Discovery; In Vivo/In Vitro Biological Assays; Medicinal Chemistry; Mitochondrial Matrix Proteases; Structural Biology

$1,143,675

Development of boron-based inhibitors of the mitochondrial ClpXP protease to combat AML

Co-investigatorCIHR2022Project Grant - Priority Announcement: Cancer Research

Principal investigators: Vahidi, Siavash; Yudin, Andrei

Keywords: Active Site Inhibitors; Acute Myeloid Leukemia; Blood Cancer; Drug Discovery; In Vivo/In Vitro Biological Assays; Libraries Of Small Molecules; Mitochondrial Matrix Proteases; Nmr Spectroscopy; Protein Degradation; Synthetic Chemistry

$100,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Applying for

Mention their CIHR grant from 2023

Subject: Prospective PhD student: Acute Myeloid Leukemia Dear Professor Schimmer, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. Your research on acute myeloid leukemia connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Developing allosteric inhibitors of mitochondrial ClpP protease for acute myeloid leukemia" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]