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Research
Latest papers
Hydrogen-Bonding and Hydrophobic Interaction Networks as Structural Determinants of Microbial Rhodopsin Function.
The journal of physical chemistry. B · 2024
Induced secondary structure and polymorphism in an intrinsically disordered structural linker of the CNS: solid-state NMR and FTIR spectroscopy of myelin basic protein bound to actin.
Biophysical journal · 2009
Latest funding
- $74,000
Advancing the biophysical basis of rhodopsin optogenetics
NSERC · 2024 · Principal investigator
- $150,000
Upgrade Advanced EPR/DEER Spectroscopy Facility
NSERC · 2020 · Co-investigator
- $414,000
New functionalities of microbial rhodopsins - where bioinformatics meets biophysics
NSERC · 2018 · Principal investigator
2 publications.
Hydrogen-Bonding and Hydrophobic Interaction Networks as Structural Determinants of Microbial Rhodopsin Function.
Bertalan É, Konno M, Del Carmen Marín M, Bagherzadeh R, Nagata T, Brown L, Inoue K, Bondar AN
Induced secondary structure and polymorphism in an intrinsically disordered structural linker of the CNS: solid-state NMR and FTIR spectroscopy of myelin basic protein bound to actin.
Ahmed MA, Bamm VV, Shi L, Steiner-Mosonyi M, Dawson JF, Brown L, Harauz G, Ladizhansky V
Advancing the biophysical basis of rhodopsin optogenetics
Principal investigators: Brown, Leonid
Keywords: microbial rhodopsins; optogenetics; channelrhodopsins; ion channels; photobiology; biospectroscopy; bioinformatics; membrane proteins; retinal chromophore; ion transport
Upgrade Advanced EPR/DEER Spectroscopy Facility
Principal investigators: Ernst, Oliver
New functionalities of microbial rhodopsins - where bioinformatics meets biophysics
Principal investigators: Brown, Leonid
Keywords: bioenergetics; bioinformatics; FTIR spectroscopy; ion transport; membrane proteins; microbial rhodopsins; NMR spectroscopy; photobiology; photosensory transduction; time-resolved spectroscopy
Replacement Light Scattering Instrument and Capability Enhancement ? Measuring Biomolecular Size and Surface Charge
Principal investigators: Graether, Steffen
Advanced spectrometer with time-resolved mid-infrared and near-infrared capabilities for studies of membrane proteins and polymers
Principal investigators: Brown, Leonid
Protein Knowledge Suite - ITC and DSC systems
Principal investigators: Graether, Steffen
Mechanisms of triggering novel light-switchable functions in rhodopsins: enzymes and non-proton cation pumps
Principal investigators: Brown, Leonid
Large volume preparative ultracentrifuge for the enhancement of membrane biophysics research at Guelph
Principal investigators: Brown, Leonid
NMR characterization of a light activated gene regulation system
Principal investigators: Wang, Shenlin
Keywords: Gene Regulation; Light-Driven System; Membrane Protein; Protein-Dna Interaction; Protein-Protein Interaction; System Biology
Towards structure determination in membrane proteins: fast MAS probe for sensitivity enhancement through direct proton detection
Principal investigators: Ladizhansky, Vladimir
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
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