Paul Spagnuolo, University of Guelph

Research

Acute Myeloid Leukemia Cell Death Drug Targeting Metabolism Mitochondria Complex Ii Mitochondria Vulnerability Respirometry Selective Leukemia Cell Death

Latest papers

Nutritional Composition of Hass Avocado Pulp.
Foods (Basel, Switzerland) · 2023
Bioactive Compounds from Curcuma amada and Their Effect on Acute Myeloid Leukemia.
Critical reviews in oncogenesis · 2022

All 2 publications

Latest funding

Elucidating the mechanism of avocatin B inhibition of very long chain acylCoA dehydrogenase
NSERC · 2023 · Principal investigator
$88,000
Identification and validation of nutraceuticals that prevent SARS-CoV-2 infection
CIHR · 2020 · Nominated PI
$211,250
Targeting mitochondria metabolism to selectively kill leukemia cells
CIHR · 2020 · Nominated PI
$367,200

All 4 grants and awards

2 publications.

01

Nutritional Composition of Hass Avocado Pulp.

Ford NA, Spagnuolo P, Kraft J, Bauer E

Foods (Basel, Switzerland)2023

DOI: 10.3390/foods12132516 PMID: 37444254

02

Bioactive Compounds from Curcuma amada and Their Effect on Acute Myeloid Leukemia.

Chandran A, Jayasankar V, Spagnuolo P, Subramanian J

Critical reviews in oncogenesis2022

DOI: 10.1615/critrevoncog.2023047542 PMID: 37183936

Elucidating the mechanism of avocatin B inhibition of very long chain acylCoA dehydrogenase

Principal investigatorNSERC2023Discovery Grants Program - Individual

Principal investigators: Spagnuolo, Paul

Keywords: Avocadyne; Avocatin B; Binding kinetics; Fatty acid oxidation; Metabolism; Mitochondria; Very long chain acyl-coA dehydrogenase

$88,000

Identification and validation of nutraceuticals that prevent SARS-CoV-2 infection

Nominated PICIHR2020Operating Grant: COVID-19 Rapid Research Funding Opportunity - Therapeutics

Principal investigators: Spagnuolo, Paul

Keywords: Covid-19; Hace2; Nutraceuticals; Pharmacokinetics; Prevent Infection; S-Glycoprotein; Sars-Cov-2

$211,250

Targeting mitochondria metabolism to selectively kill leukemia cells

Nominated PICIHR2020Project Grant

Principal investigators: Spagnuolo, Paul

Keywords: Acute Myeloid Leukemia; Cell Death; Drug Targeting; Metabolism; Mitochondria Complex Ii; Mitochondria Vulnerability; Respirometry; Selective Leukemia Cell Death

$367,200

Comprehensive assessment of mitochondrial bioenergetics; enabling simultaneous measurements in controlled oxygen environments

Co-investigatorNSERC2018Research Tools and Instruments

Principal investigators: Holloway, Graham

$69,031

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2023

Subject: Prospective PhD student: Acute Myeloid Leukemia Dear Professor Spagnuolo, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Nutritional Composition of Hass Avocado Pulp." (2023), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Elucidating the mechanism of avocatin B inhibition of very long chain acylCoA dehydrogenase" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]