Faculty profile
Jeffrey Dilworth
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Read how they describe their research on their University of Ottawa profile.
Latest papers
A chemical toolbox for the study of bromodomains and epigenetic signaling.
Nature communications · 2019
Latest funding
- $937,126
Role for defective enhancer commissioning in the hypotonia phenotype of Kabuki Syndrome patients
CIHR · 2022 · Nominated PI
- $902,700
Skeletal muscle energetics and metabolic programming in treatment -sensitive and -resistant obesity
CIHR · 2022 · Co-investigator
- $940,950
Characterizing the non-redundant roles for histone modifying enzymes in stem cell-mediated muscle repair.
CIHR · 2021 · Nominated PI
1 publications.
A chemical toolbox for the study of bromodomains and epigenetic signaling.
Wu Q, Heidenreich D, Zhou S, Ackloo S, Krämer A, Nakka K, Lima-Fernandes E, Deblois G, Duan S, Vellanki RN, Li F, Vedadi M, Dilworth J, Lupien M, Brennan PE, Arrowsmith CH, Müller S, Fedorov O, Filippakopoulos P, Knapp S
Role for defective enhancer commissioning in the hypotonia phenotype of Kabuki Syndrome patients
Principal investigators: Dilworth, Jeffrey J
Keywords: Cut&Tag; Enzymatic Function; Epigenetics; Histology; Histone Modifications; Muscle Regeneration; Myofibers; Rna-Sequencing; Stem Cells
Skeletal muscle energetics and metabolic programming in treatment -sensitive and -resistant obesity
Principal investigators: Harper, Mary-Ellen
Keywords: Bariatric Surgery; Bioinformatics; Exercise; Metabolic Programming; Metabolism; Metabolomics; Mitochondria; Obesity; Skeletal Muscle
Characterizing the non-redundant roles for histone modifying enzymes in stem cell-mediated muscle repair.
Principal investigators: Dilworth, Jeffrey J
Keywords: Dcas9; Epigenetics; Gene Expression; H3k27me3 Demethylases; Histone Modifications; Jmjd3; Muscle Regeneration; Single-Cell Rna Sequencing; Stem Cells; Transcription
Regulation of the epigenome by replication stress in vascular disease and aging
Principal investigators: Stanford, William L; Hendzel, Michael J
Keywords: Chromatin Conformation And Architecture; Disease Modeling; Epigenome; Human Induced Pluripotent Stem Cells (Ipscs); Replication Stress; Vascular Aging
Canadian Epigenetics, Environment and Health Research Consortium Network Phase II
Principal investigators: Hirst, Martin; Bourque, Guillaume
Keywords: Dna; Epigenetics; Health; Knowledge Translation; Network; Outreach; Training
Targeting the epigenetic state of refractory and relapsing acute myeloid leukemia
Principal investigators: Stanford, William L; Brand, Marjorie C; Couture, Jean-François; Dilworth, Jeffrey J; Ito, Caryn
Keywords: Acute Myeloid Leukemia (Aml); Drug Development; Epigenetics; Polycomb Repressive Complex 2; Trithorax
Epigenetic changes affecting muscle stem cell function in the aging population
Principal investigators: Dilworth, Jeffrey J; Beaule, Paul E; Bourque, Guillaume; Brand, Marjorie C; Carsen, Sasha; Lapner, Peter; Liew, Allan
Keywords: Aging; Cytof; Epigenetics; Gene Expression; Histone Methylation; Muscle Regeneration; Stem Cells
Characterizing in vitro and in vivo effects of negative elongation factor (NELF) in myogenesis
Principal investigators: Robinson, Daniel C
Keywords: Drb Sensitive Inducing Factor (Dsif); Muscle Degenerative Diseases; Myogenesis; Negative Elongation Factor (Nelf)
Role of oncogenic transcription factors in T-cell acute lymphoblastic leukemia
Principal investigators: Brand, Marjorie C
Keywords: Chromatin Immunoprecipitation And Sequencing; Epigenetics; Gene Expression Profiling; Knock Down; Oncogenes; Proteomics; Rna Sequencing; T-Cell Acute Lymphoblastic Leukemia; Transcription Factors; Xenograft
Epigenetic regulation of muscle gene expression during muscle regeneration
Principal investigators: Dilworth, Jeffrey J
Keywords: Epigenetics; Gene Expression; Histone Demethylation; Histone Methylation; Knockout Mouse; Muscle Regeneration; Muscular Dystrophy
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
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Profile data last refreshed on September 26, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.