Kin Chan, University of Ottawa

Research

Read how they describe their research on their University of Ottawa profile.

Latest papers

The mutagenic properties of formaldehyde and acetaldehyde: Reflections on half a century of progress.
Mutation research · 2025 · senior author
Mutagenesis induced by protonation of single-stranded DNA is linked to glycolytic sugar metabolism.
Mutation research · 2023 · senior author
Analyses of mutational patterns induced by formaldehyde and acetaldehyde reveal similarity to a common mutational signature.
G3 (Bethesda, Md.) · 2022 · senior author

All 7 publications

Latest funding

In utero exposure to mutagens - a critical overlooked window of genetic susceptibility
CIHR · 2023 · Co-investigator
$100,000
Engaging trainees from historically underrepresented groups at the 13th International Conference on Environmental Mutagens
CIHR · 2022 · Co-investigator
$10,000
Using cancer hypermutation to genetically engineer better bioethanol-producing yeasts
SSHRC · 2018 · Principal investigator
$273,310

All 5 grants and awards

7 publications.

01

The mutagenic properties of formaldehyde and acetaldehyde: Reflections on half a century of progress.

Thapa MJ, Chan K

Mutation research2025Senior author

DOI: 10.1016/j.mrfmmm.2024.111886 PMID: 39549522

02

Mutagenesis induced by protonation of single-stranded DNA is linked to glycolytic sugar metabolism.

Gelova SP, Chan K

Mutation research2023Senior author

DOI: 10.1016/j.mrfmmm.2023.111814 PMID: 36634476

03

Analyses of mutational patterns induced by formaldehyde and acetaldehyde reveal similarity to a common mutational signature.

Thapa MJ, Fabros RM, Alasmar S, Chan K

G3 (Bethesda, Md.)2022Senior author

DOI: 10.1093/g3journal/jkac238 PMID: 36073936

04

Intrinsic base substitution patterns in diverse species reveal links to cancer and metabolism.

Gelova SP, Doherty KN, Alasmar S, Chan K

Genetics2022Senior author

DOI: 10.1093/genetics/iyac144 PMID: 36149294

05

Analyzing the impact of CFP1 mutational landscape on epigenetic signaling.

Yang Y, Yang Y, Chan K, Couture JF

FASEB journal : official publication of the Federation of American Societies for Experimental Biology2021

DOI: 10.1096/fj.202100427r PMID: 34320252

06

Somatic mutation distributions in cancer genomes vary with three-dimensional chromatin structure.

Akdemir KC, Le VT, Kim JM, Killcoyne S, King DA, Lin YP, Tian Y, Inoue A, Amin SB, Robinson FS, Nimmakayalu M, Herrera RE, Lynn EJ, Chan K, Seth S, Klimczak LJ, Gerstung M, Gordenin DA, O'Brien J, Li L, Deribe YL, Verhaak RG, Campbell PJ, Fitzgerald R, Morrison AJ, Dixon JR, Andrew Futreal P

Nature genetics2020

DOI: 10.1038/s41588-020-0708-0 PMID: 33020667

07

Molecular Genetic Characterization of Mutagenesis Using a Highly Sensitive Single-Stranded DNA Reporter System in Budding Yeast.

Chan K

Methods in molecular biology (Clifton, N.J.)2018First author

DOI: 10.1007/978-1-4939-7306-4_4 PMID: 29043615

In utero exposure to mutagens - a critical overlooked window of genetic susceptibility

Co-investigatorCIHR2023Operating Grant - PA: Genetics (Bridge Funding: Research Priorities)

Principal investigators: Yauk, Carole L; Marchetti, Francesco

Keywords: Cancer Driver Genes; Development; Dna Damage; Error-Corrected Next-Generation Sequencing; In Utero Versus Adult Exposures; Mutagenesis; Mutations; Reproductive Health; Somatic Mosaicism

$100,000

Engaging trainees from historically underrepresented groups at the 13th International Conference on Environmental Mutagens

Co-investigatorCIHR2022Planning and Dissemination Grant - Institute Community Support

Principal investigators: Yauk, Carole L

Keywords: Cancer; Environmental Exposures; Genetic Toxicology; Genomics; Health Care; High Throughput Approaches; Mutagenesis; Mutations; Personalized Medicine; Risk Assessment

$10,000

Using cancer hypermutation to genetically engineer better bioethanol-producing yeasts

Principal investigatorSSHRC2018New Frontiers in Research Fund

Principal investigators: Chan, Kin

Keywords: cancer, bioethanol, climate change, hypermutation, yeast

$273,310

Molecular Genetic and Genomic Analysis of Mutation Clusters Induced by Ubiquitous Endogenous Mutagenic Processes in Highly Sensitized Yeast Model Systems

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Chan, Kin

$231,000

Canada Research Chair - Tier 2

Nominated PICIHR2017Canada Research Chairs - CIHR Funded - Tier 2

Principal investigators: Chan, Kin

Keywords: Cr

$500,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Jean-François Couture

Biochemistry, Microbiology and Immunology

1 shared papers, latest 2021

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Subject: Prospective PhD student Dear Professor Chan, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "The mutagenic properties of formaldehyde and acetaldehyde: Reflections on half a century of progress." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]