Maxime Rousseaux

Exploring RNA binding protein SUMOylation

Principal investigators: OGUNKINLE, MORENIKE

Keywords: Cell; Function; Ligases; Mammalian Brain; Post Translation Modifications; Ptm Regulation; Regulated; Stress Response

Stress-dependent TDP-43 SUMOylation coordinates neuronal homeostasis in ALS/FTD.

Principal investigators: McDonald, Donovan W

Keywords: Aging; Als; Ftd; Human Ipsc; Mouse Model; Neurodegenerative Disease; Neuron; Stress; Sumoylation; Tdp-43

2025 CSMB-PRinCE Conference - 68th Annual Conference for Canadian Society for Molecular Biosciences (CSMB) and 4th Biennial Proteostasis Researchers in Canada, Eh (PRinCE) Conference

Principal investigators: Lee, Jyh-Yeuan

Keywords: Cell Stress Responses; Human Genetics; Liquid-Liquid Phase Seperation; Metabolic And Cardiovascular Diseases; Molecular Biosciences; Neurodevelopment And Neurodegeration; Post-Translational Modificaton; Protein Homeostasis; Protein Misfolding And Aggregation; Protein Trafficking And Degradation

TDP-43 SUMOylation safeguards the brain against age-associated neuropathology.

Principal investigators: Rousseaux, Maxime W

Keywords: Aging; Amyotrophic Lateral Sclerosis; Frontotemporal Dementia; Proximity Ligation Assay; Sumoylation; Tdp-43

Canada Research Chair - Tier 2

Principal investigators: Rousseaux, Maxime W

Keywords: Crc

Determining the subnuclear localization of alpha-synuclein and the molecular mechanisms of nuclear alpha-synuclein toxicity

Principal investigators: Geertsma, Haley

Keywords: Alpha-Synuclein; Confocal Microscopy; Crispr; Cut&Run; Dcas9; Immuno-Electron Microscopy; Parkinson'S Disease; Subnuclear Localization

Mechanisms of neuronal demise via a-Syn mislocalization in neurodegenerative diseases

Principal investigators: Rousseaux, Maxime W

Keywords: Alpha-Synuclein; Behaviour; Mislocalization; Mouse Models; Neuropathology; Parkinson'S Disease; Primary Neuron Culture; Protein Misfolding; Synaptojanin1; Synucleinopathy

SUMOylation guides synaptic protein localization and function in mammalian brain development.

Principal investigators: Rousseaux, Maxime

SUMOylation guides synaptic protein localization and function in mammalian brain development.

Principal investigators: Rousseaux, Maxime

Keywords: sumoylation; protein localization; brain development; post-translational modification; mouse genetics; neuronal activity; proteomics; camkii

Rapid and effective generation of organism-wide cell-of-origin anatomical maps in mammals.

Principal investigators: Rousseaux, Maxime

Keywords: iDISCO+; alpha-synuclein; Genome engineering;Mouse models; Data visualization; Cell-of-origin studies; Selective vulnerability; Anatomy; Biomedical Data Science