Thomas Lagace, University of Ottawa

Research

Read how they describe their research on their University of Ottawa profile.

Low-Density Lipoprotein Receptor Protein-Protein Interaction Apolipoprotein B Protein Degradation Allosteric Regulation Gain-Of-Function Mutations Intrinsically Disordered Region Lipoprotein Metabolism

Latest papers

Whole-Gene Duplication of PCSK9 as a Novel Genetic Mechanism for Severe Familial Hypercholesterolemia.
The Canadian journal of cardiology · 2018

All 1 publications

Latest funding

Molecular determinants and physiological role of PCSK9-LDL association
CIHR · 2025 · Nominated PI
$780,300
Regulation of the PCSK9 binding interaction with LDL receptor
CIHR · 2017 · Nominated PI
$573,750
Mechanism of LDL Receptor Degradation by PCSK9
CIHR · 2014 · Nominated PI
$548,813

All 5 grants and awards

1 publications.

01

Whole-Gene Duplication of PCSK9 as a Novel Genetic Mechanism for Severe Familial Hypercholesterolemia.

Iacocca MA, Wang J, Sarkar S, Dron JS, Lagace T, McIntyre AD, Lau P, Robinson JF, Yang P, Knoll JH, Cao H, McPherson R, Hegele RA

The Canadian journal of cardiology2018

DOI: 10.1016/j.cjca.2018.07.479 PMID: 30269829

Molecular determinants and physiological role of PCSK9-LDL association

Nominated PICIHR2025Project Grant

Principal investigators: Lagace, Thomas A

Keywords: Allosteric Regulation; Apolipoprotein B; Gain-Of-Function Mutations; Intrinsically Disordered Region; Lipoprotein Metabolism; Low-Density Lipoprotein Receptor; Pcsk9 (Proprotein Convertase Subtilisin/Kexin Type-9); Post-Translational Modifications; Protein Conformational Dynamics; Protein-Protein Interaction

$780,300

Regulation of the PCSK9 binding interaction with LDL receptor

Nominated PICIHR2017Project Grant

Principal investigators: Lagace, Thomas A

Keywords: Apolipoprotein B; Low-Density Lipoprotein; Low-Density Lipoprotein Receptor; Pcsk9 - Proprotein Convertase Subtilisin/Kexin Type-9; Protein Degradation; Protein Structure; Protein-Protein Interaction

$573,750

Mechanism of LDL Receptor Degradation by PCSK9

Nominated PICIHR2014Operating Grant

Principal investigators: Lagace, Thomas A

Keywords: Calcium Binding; Endocytic Receptor Recycling; Epidermal Growth Factor-Like Domains; Low-Density Lipoprotein Receptor; Proprotein Convertase Subtilisin/Kexin Type-9; Protein Degradation; Protein Trafficking; Protein-Protein Interaction

$548,813

Mechanisms of interorganelle cholesterol trafficking

Principal investigatorNSERC2010Discovery Grants Program - Individual

Principal investigators: Lagace, Thomas

$155,000

Mechanism of LDL Receptor Degradation by PCSK9

Nominated PICIHR2010Operating Grant

Principal investigators: Lagace, Thomas A

Keywords: Calcium Binding; Endocytic Receptor Recycling; Epidermal Growth Factor-Like Domains; Low-Density Lipoprotein Receptor; Proprotein Convertase Subtilisin/Kexin Type-9; Protein Crystallography; Protein Degradation; Protein-Protein Interaction

$282,011

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Ruth McPherson

Medicine

1 shared papers, latest 2018

Write to this professor

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Applying for

Mention their CIHR grant from 2025

Subject: Prospective PhD student: Low-Density Lipoprotein Receptor Dear Professor Lagace, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Whole-Gene Duplication of PCSK9 as a Novel Genetic Mechanism for Severe Familial Hypercholesterolemia." (2018), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Molecular determinants and physiological role of PCSK9-LDL association" (2025), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]