William Stanford

Development of Novel Antisense Oligonucleotide Therapies Targeting Aberrant Splicing to Overcome Cancer Treatment Resistance

Principal investigators: Zhang, Liwen

Keywords: Alternative Splicing; Antisense Oligonucleotides (Asos); Cancer Therapeutics; Splicing Factors; Therapy Resistance

Cellular and molecular pathogenesis of renal tuberous sclerosis complex

Principal investigators: Stanford, William L

Keywords: Chronic Kidney Disease; Cystogenesis; Human Pluripotent Stem Cells; Mouse Models Of Disease; Renal Angiomyolipoma; Renal Organoids; Single-Cell Omics; Tuberous Sclerosis Complex; Xenograft Models

Cellular and molecular pathogenesis of renal tuberous sclerosis complex

Principal investigators: Stanford, William L

Keywords: Chronic Kidney Disease; Cystogenesis; Human Pluripotent Stem Cells; Mouse Models Of Disease; Renal Angiomyolipoma; Single-Cell Omics; Tuberous Sclerosis Complex; Xenograft Models

Genetic mechanisms of coronary artery calcification: focus on IRF2BP2

Principal investigators: Stewart, Alexandre F; Stanford, William L

Keywords: Arterial Calcification; Arterial Smooth Muscle Cells; Bone Morphogenic Protein; Crispr/Cas9 Technology; Genetic Association Study; Human Ipsc; Innate Immune Mechanisms; Mouse Genetic Models; Runx2; Sex Differences

Dissecting the roles of the Polycomb protein MTF2 in leukemogenesis

Principal investigators: Stanford, William L

Keywords: Acute Myeloid Leukemia (Aml); Chemoresistance; Chromatin Immunoprecipitation; Dna Damage Response; Epigenetics; Gene Regulatory Networks; Hematopoiesis; Transcriptomics

Systems Biology-based tissue engineering

Principal investigators: Stanford, William

Keywords: transcriptomics; tissue engineering; gene regulatory networks; integrative biology; epigenetics; pluripotent stem cells; embryonic stem cells; neural crest; translomics

Proteomic characterization of molecular pathways at the single-cell level in human heterogeneous systems

Principal investigators: Benoit, Yannick

Regulation of the epigenome by replication stress in vascular disease and aging

Principal investigators: Stanford, William L

Keywords: Chromatin Conformation And Architecture; Disease Modeling; Epigenome; Human Induced Pluripotent Stem Cells (Ipscs); Replication Stress; Vascular Aging

Regulation of the epigenome by replication stress in vascular disease and aging

Principal investigators: Stanford, William L; Hendzel, Michael J

Keywords: Chromatin Conformation And Architecture; Disease Modeling; Epigenome; Human Induced Pluripotent Stem Cells (Ipscs); Replication Stress; Vascular Aging

Targeting the epigenetic state of refractory and relapsing acute myeloid leukemia

Principal investigators: Stanford, William L; Brand, Marjorie C; Couture, Jean-François; Dilworth, Jeffrey J; Ito, Caryn

Keywords: Acute Myeloid Leukemia (Aml); Drug Development; Epigenetics; Polycomb Repressive Complex 2; Trithorax