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Research
Latest papers
Gene Portals: A Framework for Integrating Clinical, Functional, and Structural Evidence into Rare Disease Variant Classification.
medRxiv : the preprint server for health sciences · 2026
Enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo.
Journal of neurochemistry · 2021
Neuron-specific deficits of bioenergetic processes in the dorsolateral prefrontal cortex in schizophrenia.
Molecular psychiatry · 2019
Latest funding
- $1,239,300
Gene augmentation to treat GRIN Neurodevelopmental Disorder
CIHR · 2026 · Nominated PI
- $450,000
Exploring mechanisms and treatments for GRIN neurodevelopmental disorders
CIHR · 2025 · Nominated PI
- $3,934,956
MitoRevolution: Mitochondrial Transplantation Transforming Regenerative Medicine - from research to patient care to global impact.
SSHRC · 2024 · Co-investigator
4 publications.
Gene Portals: A Framework for Integrating Clinical, Functional, and Structural Evidence into Rare Disease Variant Classification.
Brünger T, Krey I, Kim S, Klöckner C, Myers SJ, Johannesen KM, Stefanski A, Taylor G, Perez-Palma E, Macnee M, Schorge S, Dahl RS, Yuan H, Perszyk RE, Kim S, Bajaj S, Helbig I, Pan JQ, Farrant M, Wollmuth L, Wyllie DJA, Kurganov E, Baez D, Zuberi S, Boßelmann CM, Lerche H, Mantegazza M, Cestèle S, May P, Ivaniuk A, Meskis MA, Hood V, Schust L, Goodspeed K, Kang JQ, Freed A, Gati C, Montanucci L, Wuster A, Trinidad M, Froelich S, Deng AT, Serrano ÁA, Borovikov A, Sharkov A, Bouman A, Hajianpour MJ, Pal DK, Danvoye L, Lederer D, Balci TR, Hagebeuk EEO, Heidlebaugh A, Oetjens K, Hoffman TL, Striano P, Williams SD, van Engelen K, Howell KB, Khoury J, Benke TA, Strehlow V, Platzer K, Ramsey A, Manaster L, Malepati S, Fox P, Noebels J, Chung W, Poduri A, Stripe LL, Ruggiero SM, Cohen S, Smith L, Boesch S, Wilmarth O, Prentice AJ, Cha E, Budnik N, Hommersom MP, Kramer A, Vanoye CG, Zhang GQ, Nothnagel M, Palotie A, Daly MJ, George AL, Zarate YA, Brunklaus A, Traynelis SF, Møller RS, Lemke JR, Lal D
Enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo.
Vecchio LM, Sullivan P, Dunn AR, Bermejo MK, Fu R, Masoud ST, Gregersen E, Urs NM, Nazari R, Jensen PH, Ramsey A, Goldstein DS, Miller GW, Salahpour A
Neuron-specific deficits of bioenergetic processes in the dorsolateral prefrontal cortex in schizophrenia.
Sullivan CR, Koene RH, Hasselfeld K, O'Donovan SM, Ramsey A, McCullumsmith RE
Defects in Bioenergetic Coupling in Schizophrenia.
Sullivan CR, O'Donovan SM, McCullumsmith RE, Ramsey A
Gene augmentation to treat GRIN Neurodevelopmental Disorder
Principal investigators: Ramsey, Amy J
Keywords: Autism; Epilepsy; Gene Therapy; Intellectual Disability; Lipid Nanoparticle; Mouse Behaviour; Movement Disorder; Neurodevelopmental; Nmda Receptor; Rare Disease
Exploring mechanisms and treatments for GRIN neurodevelopmental disorders
Principal investigators: Ramsey, Amy J
Keywords: Biologic; Biomarker; Drug Development; Grin1; Grin2a; Grin2b; Grin2d; Mouse; Nanobody; Rare Disease
MitoRevolution: Mitochondrial Transplantation Transforming Regenerative Medicine - from research to patient care to global impact.
Principal investigators: Andreazza, Ana
Modulation of the endocannabinoid system in mouse models of GRIN1 disorder
Principal investigators: Sullivan, Megan T
Keywords: Endocannabinoid System; Grin1; Mouse Models; Nmda Receptor
Targeting cortical integrative mechanisms to treat cognitive impairment
Principal investigators: Lambe, Evelyn K
Keywords: Behaviour; Cerebral Cortex; Cognitive Deficits; Dendritic Plateau Potentials; Electrophysiology; Glutamate Receptors; Pharmacology; Prefrontal Cortex; Synaptic Integration; Transgenic Mice
Development and Characterization of Novel CB1 Allosteric Modulators
Principal investigators: Ross, Ruth A
Keywords: Cannabinoid; Drug Discovery; Mental Health
Improving treatment for GRIN disorders
Principal investigators: Ramsey, Amy J
Keywords: Autism; Behaviour; Epilepsy; Intellectual Disability; Mouse Model; Neurodevelopmental Disorder; Nmda Receptor; Rare Genetic Disorder
Molecular pathways connecting NMDA receptors to the actin cytoskeleton
Principal investigators: Ramsey, Amy
Molecular pathways connecting NMDA receptors to synapse number
Principal investigators: Ramsey, Amy
Plasticity of neural circuits relevant to schizophrenia
Principal investigators: Ramsey, Amy J
Keywords: Animal Model; Behavioural Pharmacology; Cre Recombination; Neurodevelopment; Nmda Receptor; Schizophrenia
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
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