Andrew Fraser

Deep structure-function analysis of structure-switching aptamers - learning the design rules underlying aptamer-target recognition

Principal investigators: Fraser, Andrew G

Keywords: Metabolite; Metabolite Detection Drug Detection; New Platform; Sensor; Structure-Switching Aptamer

Establishing a rapid selection method for selection of high affinity aptamer sensors containing non-natural nucleic acids

Principal investigators: Fraser, Andrew G

Keywords: Aptamer; Biosensor; Dna Barcode; Metabolite Detection; Non-Natural Nucleic Acids

New drugs and new targets: in search of new classes of drugs that inhibit rhodoquinone-dependent metabolism, an unusual form of anaerobic metabolism that allows parasites to survive in the human gut

Principal investigators: Fraser, Andrew G

Keywords: C.Elegans Model; Drug Discovery; Helminth; High Throughput Phenotyping; In Silico Predictions; Metabolic Networks; Quantitative Phenotyping

Combining in vivo and in silico screening to identify new classes of anthelmintics targeting rhodoquinone-dependent metabolism

Principal investigators: Fraser, Andrew G

Keywords: C.Elegans Model; Drug Discovery; Helminth; High Throughput Phenotyping; Metabolic Networks; Quantitative Phenotyping; Rhodoquinone

Reading metabolites with DNA barcodes - establishing barcode structure switching aptamers as a new platform for metabolomics

Principal investigators: Fraser, Andrew G

Keywords: Barcode; Drug; Metabolite; Sensors; Single Cell; Small Molecule

A platform for massively parallel metabolite analysis in single cells

Principal investigators: Fraser, Andrew

Using C.elegans to understand how the GAR-3 muscarinic acetylcholine receptor modulates other signaling pathways

Principal investigators: Fraser, Andrew G

Keywords: C.Elegans; Genetic Screens; Image-Based Assays; Neurotransmitters

Using C.elegans to learn to predict the personal severity of mutant phenotypes

Principal investigators: Fraser, Andrew G

Keywords: C.Elegans; Gene Expression; Gene Networks; Mutant Phenotypes; Quantitative Phenotyping; Rnai Screening

Using C.elegans to understand how the gar-3 muscarinic acetylcholine receptor modulates other signaling pathways

Principal investigators: Fraser, Andrew G

Keywords: C.Elegans; Crosstalk; Drug Screens; Genetic Screens; Neuromuscular System; Signaling

Using C.elegans to identify drugs that target a metabolic pathway that is essential for parasitic helminths but absent from humans

Principal investigators: Fraser, Andrew G

Keywords: Anaerobic Metabolism; C.Elegans; Drug Screen; Metabolomics; Novel Drugs; Parasitic Helminths