Basil Hubbard, University of Toronto

Research

Base Editors Cas9 Chemically-Modified Nucleotides Computational Analysis Crispr Enzyme Specificity Gene Editing Genetic Engineering

Latest funding

Increasing the specificity of Cas9 gene editing agents through computationally-guided inclusion of xenonucleic acids in crRNAs
CIHR · 2023 · Nominated PI
$1,124,550
Pulmonary delivery of base editors for gene therapy of cystic fibrosis with nonsense mutations
CIHR · 2023 · Co-investigator
$1,166,625
Tools for advancing the versatility and reliability of RNA editing
NSERC · 2023 · Principal investigator
$120,000

All 4 grants and awards

Increasing the specificity of Cas9 gene editing agents through computationally-guided inclusion of xenonucleic acids in crRNAs

Nominated PICIHR2023Project Grant

Principal investigators: Hubbard, Basil P

Keywords: Base Editors; Cas9; Chemically-Modified Nucleotides; Computational Analysis; Crispr; Enzyme Specificity; Gene Editing; Genetic Engineering; Off-Target Dna Cutting And Nicking; Xenonucleic Acids

$1,124,550

Pulmonary delivery of base editors for gene therapy of cystic fibrosis with nonsense mutations

Co-investigatorCIHR2023Project Grant

Principal investigators: Li, Bowen

Keywords: Base Editing; Biomaterials; Cystic Fibrosis; Drug Delivery; Gene Editing; Genetic Disease; Genomic Medicine; Lipid Nanoparticles; Mrna Delivery; Noviral Gene Therapy

$1,166,625

Tools for advancing the versatility and reliability of RNA editing

Principal investigatorNSERC2023Discovery Grants Program - Individual

Principal investigators: Hubbard, Basil

Keywords: Cas13; Chemical probes; CRISPR; Gene editing; RNA binding specificity; RNA cleavage specificity; RNA editing; Small-molecule inhibitors; Temporal control of RNA editing in mammalian cells; Titration of RNA editing effect

$120,000

Towards non-DNA based life: design and evolution of cells subsisting on chemically-altered ribose sugars

Principal investigatorSSHRC2023New Frontiers in Research Fund - Exploration

Principal investigators: Hubbard, Basil

Keywords: Computational modelling of nucleic acids; Organic synthesis of carbohydrates; ribose sugar derivatives; genetically engineered microbes; adaptive laboratory evolution; xenonucleic acids; non-DNA based life; synthetic biology; primordial biomolecules; CRISPR

$250,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Mention their CIHR grant from 2023

Subject: Prospective PhD student: Base Editors Dear Professor Hubbard, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. Your research on base editors connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Increasing the specificity of Cas9 gene editing agents through computationally-guided inclusion of xenonucleic acids in crRNAs" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]