Christopher Pearson

Somatic repeat instability, CpG-methylation and chromosomal instability determine disease penetrance and disease heterogeneity in C9orf72 expansion carriers

Principal investigators: Pearson, Christopher E

Keywords: Als/Ftd; Chromatin Accessibility; In Vitro Assays; In Vivo Animal Work; Mouse Model; Post-Mortem Tissues; Repeat Binding Compounds; Repeat Expansion Disease; Somatic Instability

Regulating Alternate-Replication Protein A in DNA Repeat Expansion Diseases - Su Wang, MSc

Principal investigators: Wang, Su

Keywords: Bioinformatics; Dna Repair; Dna Repeat Instability; Dna Replication Protein; Gene Expression Regulation; Huntington'S Disease

Pre-clinical studies of a small-molecule to reverse neurodegenerative disease-causing mutations for its commercialization and application

Principal investigators: Pearson, Christopher E

Keywords: Cag/Ctg Repeat Expansions; Commercialization; Huntington'S Disease; Naphtyridine Azaquinolone (Na); Pre-Clinical Studies; Repeat Instability; Small Compound; Spinocerebellar Ataxia (Scas); Transgenic Mice

FAN1, a DNA repair nuclease, as a modifier of disease-associated repeat instability.

Principal investigators: Pearson, Christopher E

Keywords: Cag/Ctg Repeat Expansions; Dna Repair; Fan1 Nuclease; Fan1-Mlh1 Interaction; Huntington'S Disease; Mlh1 Complex; Repeat Instability; Spinocerebellar Ataxia (Scas); Transgenic Mice

DNA repair proteins as modifiers of CAG repeat instability in Huntington's disease

Principal investigators: Pearson, Christopher E

Keywords: Cag Repeat Expansion; Dna Repair; Huntington'S Disease; Repeat Instability; Replication Protein A (Rpa)

Somatic DNA mosaicism of the ADNP gene in cells, ADNP-mouse tissues and tissues of a post-mortem ADNP individual: An indication of how this may affect disease.

Principal investigators: Pearson, Christopher E

Keywords: Autism, Adnp, Somatic Mosaicism, Digital Droplet Pcr

Canada Research Chair - Tier 1

Principal investigators: Pearson, Christopher E

Keywords: Crc

Myotonic Dystrophy and Congenital form: genetic and epigenetic marks associated with CTG/CAG repeat instability

Principal investigators: Pearson, Christopher E

Keywords: Congenital Myotonic Dystrophy; Dna Methylation; Epigenetics; Myotonic Dystrophy Type 1; Parent-Of-Origin Effect; Repeat Instability

Nucleic acid-binding ligands as modulators of repeat instability for therapeutic benefit against neurological and neuromuscular diseases.

Principal investigators: Pearson, Christopher E

Keywords: Binding Assay; Cell Lines Treatment; Nucleic-Acid Binding Ligands; Repair Assay; Repeat Instability; Replication Assay; Treatment Of Mice Models

Formation and biological functions of unusual DNA/RNA structures formed by repeat sequences.

Principal investigators: Pearson, Christopher