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Research
Latest papers
Exploring the association of interleukin polymorphisms with aggression and internalizing behaviors in children and adolescents.
Brain and behavior · 2022
Older molecular brain age in severe mental illness.
Molecular psychiatry · 2021
Latest funding
- $726,750
Impact of Genomic Factors in Accidental Lethal Opioid Overdose
CIHR · 2025 · Nominated PI
- $1,510,875
Metformin for treatment-resistant bipolar depression (TRBD) with co-morbid insulin resistance (IR): A double-blind randomized control trial
CIHR · 2025 · Co-investigator
- $1,013,626
Predicting risk for treatment-resistant depression using pharmacogenomic-based modeling
CIHR · 2024 · Nominated PI
2 publications.
Exploring the association of interleukin polymorphisms with aggression and internalizing behaviors in children and adolescents.
Pouget JG, Bryushkova L, Koyama E, Zai CC, Fonseka TM, Mueller D, Kennedy JL, Beitchman JH
Older molecular brain age in severe mental illness.
Lin CW, Chang LC, Ma T, Oh H, French B, Puralewski R, Mathews F, Fang Y, Lewis DA, Kennedy JL, Mueller D, Marshe VS, Jaffe A, Chen Q, Ursini G, Weinberger D, Newman AB, Lenze EJ, Nikolova YS, Tseng GC, Sibille E
Impact of Genomic Factors in Accidental Lethal Opioid Overdose
Principal investigators: Mueller, Daniel J; Le Foll, Bernard
Keywords: Genomics; Lethal Overdose; Opioids; Pharmacogenetics; Polygenic Risk Scores; Substance Use Disorder
Metformin for treatment-resistant bipolar depression (TRBD) with co-morbid insulin resistance (IR): A double-blind randomized control trial
Principal investigators: Hahn, Margaret; Agarwal, Sri Mahavir; Kloiber, Stefan M; Mansur, Rodrigo B; Saraf, Gayatri; Taylor, Valerie Hannah
Keywords: Bipolar Disorder; Depression; Insulin Resistance; Metformin; Treatment Resistance
Predicting risk for treatment-resistant depression using pharmacogenomic-based modeling
Principal investigators: Mueller, Daniel J; Kloiber, Stefan M
Keywords: Depression; Machine Learning; Mental Health; Pharmacogenomics; Sex Differences
Influence of polygenic risk scores on longitudinal disease trajectories of individuals with schizophrenia spectrum disorders
Principal investigators: Kennedy, James L; Tiwari, Arun K; Zai, Clement
Keywords: Disease Severity; Functional Outcomes; Pharmacogenetics; Response; Schizophrenia; Schizophrenia Spectrum Disorders; Side Effects
Predicting antidepressant remission in late-life depression using polygenic risk scoring and machine learning models
Principal investigators: Mueller, Daniel J; Reimand, Jüri
Keywords: Antidepressants; Genetics; Late-Life Depression; Machine Learning; Pharmacogenetics; Polygenic Risk Scores; Predictive Modelling; Treatment Response
Semaglutide in comorbid obesity and schizophrenia-spectrum disorders for metformin non-responders: a double-blind randomized control trial
Principal investigators: Hahn, Margaret; Agarwal, Sri Mahavir
Keywords: Antipsychotics; Cognition; Diabetes; Glucagon-Like-Peptide 1 Receptor Agonists; Magnetic Resonance Imaging; Metformin; Obesity; Psychosis; Schizophrenia; Visceral Adiposity
Exploring the shared multi-omic architecture of late-life depression and cognitive decline: Discovering and predicting biologically-defined patient subtypes using machine learning
Principal investigators: Marshe, Victoria S
Keywords: Aging; Alzheimer'S Disease; Antidepressant Response; Biomarkers; Cognitive Decline; Dementia; Genomics; Late-Life Depression; Machine Learning; Pharmacogenetics
Identification and network-based characterization of molecular biomarkers associated with treatment outcomes in major depressive disorder.
Principal investigators: Maciukiewicz, Malgorzata A
Keywords: Antidepressants; Machine Learning; Placebo
Unraveling the role of central insulin action in relation to glucose abnormalities in first-time antipsychotic users
Principal investigators: Hahn, Margaret; Dash, Satya
Keywords: Antipsychotics; Cognition; Diabetes; Psychosis
Development, validation and benefits of a genetic risk model for antipsychotic-induced weight gain
Principal investigators: Mueller, Daniel J
Keywords: Antipsychotics; Genetic Risk Model; Genetics; Gwas; Health Care Costs; Metabolic Syndrome; Pharmacogenetics; Psychopharmacology; Side Effects; Weight Gain
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
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