Research
Read how they describe their research on their University of Toronto profile.
Latest papers
High Constitutive Interleukin 10 Level Interferes With the Immune Response to Varicella-Zoster Virus in Elderly Recipients of Live Attenuated Zoster Vaccine.
The Journal of infectious diseases · 2019
Latest funding
- $1,377,000
Dissecting T cell immune and therapeutic responses against soft tissue sarcomas
CIHR · 2025 · Principal investigator
- $795,600
Establishing the Preclinical Efficacy of a Dual HDAC3/8 Degrader for the Treatment of Diffuse Large B-Cell Lymphoma
CIHR · 2025 · Co-investigator
- $1,197,226
Spatial Dynamics of Interferon Signaling within the Tumor Microenvironment
CIHR · 2025 · Nominated PI
1 publications.
High Constitutive Interleukin 10 Level Interferes With the Immune Response to Varicella-Zoster Virus in Elderly Recipients of Live Attenuated Zoster Vaccine.
Gershon AA, Brooks D, Stevenson DD, Chin WK, Oldstone MBA, Gershon MD
Dissecting T cell immune and therapeutic responses against soft tissue sarcomas
Principal investigators: Kirsch, David G; Brooks, David
Keywords: Anti-Pd1 Immunotherapy; Genetically Engineered Mouse Model; Radiotherapy; Soft Tissue Sarcoma; T Cell Response
Establishing the Preclinical Efficacy of a Dual HDAC3/8 Degrader for the Treatment of Diffuse Large B-Cell Lymphoma
Principal investigators: Kridel, Robert
Keywords: Histone Deacetylases; Lymphoma; Preclinical Efficacy; Targeted Protein Degradation; Targeted Therapy
Spatial Dynamics of Interferon Signaling within the Tumor Microenvironment
Principal investigators: Brooks, David; Campbell, Kieran R
Keywords: Cancer; Immune Cells; Immunotherapy; Interferon; Spatial Analysis
Mechanistic investigations of the innate immune response to cancer cell death and immune tolerance to solid tumor antigens.
Principal investigators: McGaha, Tracy
Keywords: Chemotherapy; Cytokines; Macrophage; Tumor Immunology
Type I interferon mediated regulation of chronic virus infection
Principal investigators: Brooks, David
Keywords: Chronic Viral Infection; Interferon; Lcmv; T Cell Exhaustion; T Cells
Deciphering the spatial signaling of interferons in melanoma and following immunotherapy
Principal investigators: Cormier, Matthew C
Keywords: Cancer; Immunology; Interferons; Multiplexed Immunohistochemistry
Type I interferon mediated regulation of chronic virus infection
Principal investigators: Brooks, David
Keywords: Chronic Viral Infection; Immunotherapy; Interferon; Lcmv; T Cell Exhaustion; T Cells
Mechanisms of IRF2-driven immune regulation in the tumor microenvironment
Principal investigators: Brooks, David
Keywords: Cd8 T Cells; Immunotherapy; Interferon; Irf2; T Cell Exhaustion; Tumor Immunology
Viral mimicry tolerance as a mechanism of early tumor immune evasion
Principal investigators: De Carvalho, Daniel
Keywords: Cancer; Dna Methylation; Epigenetics; Histone Methylation; Immunotherapy; Ovarian Cancer; Therapy Resistance
Cellular and molecular mechanisms regulating the progression of atherosclerosis: exploiting macrophage reverse transendothelial migration as a therapeutic strategy
Principal investigators: Cybulsky, Myron I
Keywords: Atherosclerosis; Cell Migration; Dendritic Cells; Endothelial Cells; Inflammation; Intima; Macrophages; Monocytes; Signalling; Transgenic Mouse Models
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
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Profile data last refreshed on September 25, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.