Deborah Zamble, University of Toronto

Research

Pathogenic Bacteria Hydrogenase Production Metal Trafficking Metallocenter Assembly Nickel Proteins Nickel Uptake Nickel Use In Bacteria Small Molecule Inhibitors

Latest papers

A novel mode of control of nickel uptake by a multifunctional metallochaperone.
PLoS pathogens · 2021
ENZYMOLOGY. It costs more than a nickel.
Science (New York, N.Y.) · 2015 · first author

All 2 publications

Latest funding

Mechanisms of Nickel-Responsive Proteins
NSERC · 2020 · Principal investigator
$80,199
Ultracentrifugation Facility
NSERC · 2019 · Principal investigator
$103,009
High resolution characterization of macromolecular structure and dynamics
NSERC · 2017 · Co-investigator
$145,571

All 25 grants and awards

2 publications.

01

A novel mode of control of nickel uptake by a multifunctional metallochaperone.

Denic M, Turlin E, Michel V, Fischer F, Khorasani-Motlagh M, Zamble D, Vinella D, de Reuse H

PLoS pathogens2021

DOI: 10.1371/journal.ppat.1009193 PMID: 33444370

02

ENZYMOLOGY. It costs more than a nickel.

Zamble D

Science (New York, N.Y.)2015First author

DOI: 10.1126/science.aac5854 PMID: 26138967

Mechanisms of Nickel-Responsive Proteins

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Zamble, Deborah

$80,199

Ultracentrifugation Facility

Principal investigatorNSERC2019Research Tools and Instruments

Principal investigators: Zamble, Deborah

$103,009

High resolution characterization of macromolecular structure and dynamics

Co-investigatorNSERC2017Research Tools and Instruments

Principal investigators: Houry, Walid

$145,571

Controlled Atmospheric Environment for Cell Growth and Manipulation

Principal investigatorNSERC2017Research Tools and Instruments

Principal investigators: Zamble, Deborah

$93,316

Defining and Blocking the Production of the Nickel-Containing Hydrogenase Enzyme in Bacteria

Nominated PICIHR2015Operating Grant

Principal investigators: Zamble, Deborah B

Keywords: Hydrogenase Production; Metal Trafficking; Metallocenter Assembly; Nickel Proteins; Nickel Uptake; Nickel Use In Bacteria; Pathogenic Bacteria; Small Molecule Inhibitors; Whole-Cell Screening

$522,282

Metal Selectivity of Nickel Metalloproteins

Principal investigatorNSERC2014Discovery Grants Program - Individual

Principal investigators: Zamble, Deborah

$340,000

Fluorescence Plate Reader for Chemical Biology

Co-investigatorNSERC2014Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Nitz, Mark

$39,000

Real-Time PCR to Study Metal-Regulated Gene Expression

Principal investigatorNSERC2013Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Zamble, Deborah

$28,633

The nickel-regulated transcription factor NikR from H. pylori and E. coli

Nominated PICIHR2012Operating Grant

Principal investigators: Zamble, Deborah B

Keywords: Acid Adaptation; Dna-Binding Proteins; Metalloregulators; Mutant Proteins; Nickel Homeostasis; Pathogenic Bacteria; Transcription Factors

$466,164

A liquid chromatography system for metalloprotein purification

Principal investigatorNSERC2011Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Zamble, Deborah

$58,063

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2020

Subject: Prospective PhD student: Pathogenic Bacteria Dear Professor Zamble, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "A novel mode of control of nickel uptake by a multifunctional metallochaperone." (2021), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Mechanisms of Nickel-Responsive Proteins" (2020), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]