Evelyn Lambe

New Insights Into Cholinergic Transmission in the Interpeduncular Nucleus

Principal investigators: Richter Gorey, Claire L

Keywords: Electrophysiology; Interpeduncular Nucleus; Nicotinic Receptors; Optogenetics

A Novel SUMO2 Biologic Therapeutic for Synucleinopathies

Principal investigators: Tandon, Anurag; Fraser, Paul E; Lambe, Evelyn K; Lévesque, Martin

Keywords: Animal Model; Biologic; Electrophysiology; Neurodegeneration; Protein Aggregation; Proteinopathy; Sumo; Synaptic Dysfunction; Synucleinopathy; Therapeutic

Stress and flexibility of prefrontal serotonin signalling

Principal investigators: Lambe, Evelyn

Keywords: prefrontal cortex; serotonin; stress; optogenetics; electrophysiology; mice; postsynaptic receptors; autoregulation; synaptic integration; multiphoton imaging

Targeting cortical integrative mechanisms to treat cognitive impairment

Principal investigators: Lambe, Evelyn K

Keywords: Behaviour; Cerebral Cortex; Cognitive Deficits; Dendritic Plateau Potentials; Electrophysiology; Glutamate Receptors; Pharmacology; Prefrontal Cortex; Synaptic Integration; Transgenic Mice

Improving treatment for GRIN disorders

Principal investigators: Ramsey, Amy J

Keywords: Autism; Behaviour; Epilepsy; Intellectual Disability; Mouse Model; Neurodevelopmental Disorder; Nmda Receptor; Rare Genetic Disorder

Cholinergic prefrontal attention circuitry deficits in rodent models of Alzheimer's disease

Principal investigators: Power, Saige K

Keywords: Acetylcholine; Alzheimer'S Disease; Attention; Electrophysiology; Neuronal Synapses; Optogenetics; Prefrontal Cortex; Rodent Model

Role of cortical CCK-GABA cells in cognition and cognitive impairments of schizophrenia

Principal investigators: Kim, Junchul

Keywords: Behavioural Neuroscience; Cck; Chemogenetics; Cognition; Gaba; Optogenetics; Prefrontal Cortex; Recombinase; Schizophrenia; Working Memory

Stress and flexibility in serotonin signalling

Principal investigators: Lambe, Evelyn

Contribution of Mid-life Comorbidities to Alzheimer's Disease

Principal investigators: Mclaurin, Joanne; Lambe, Evelyn K; Stefanovic, Bojana

Keywords: Alzheimer'S Disease; Animal Models Of Disease; Comorbidities

Prefrontal attention circuitry: Mechanisms of deregulation and restoration in brain disorders

Principal investigators: Lambe, Evelyn K

Keywords: Alzheimer'S Disease Mouse Model; Attention Deficits; Behaviour; Brain Slice Electrophysiology; Depression Mouse Model; Dopamine; Muscarinic Acetylcholine Receptors; Nicotinic Acetylcholine Receptors; Prefrontal Cortex; Scylloinositol