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Research
Latest papers
Understanding genetic variants in context.
eLife · 2024
Multiplexed Assays of Variant Effect and Automated Patch Clamping Improve KCNH2-LQTS Variant Classification and Cardiac Event Risk Stratification.
Circulation · 2024
Multiplexed Assays of Variant Effect and Automated Patch-clamping Improve KCNH2-LQTS Variant Classification and Cardiac Event Risk Stratification.
medRxiv : the preprint server for health sciences · 2024
Latest funding
- $3,642,800
Systematically mapping functional human sequence variation and context-dependent protein interactions
CIHR · 2017 · Nominated PI
- $844,003
Regenerative biomaterials in vascularized tissue engineering
CIHR · 2016 · Co-investigator
- $1,399,299
From correlation to causation in genomics: identifying mechanisms underlying disease
CIHR · 2014 · Co-investigator
3 publications.
Understanding genetic variants in context.
Sinnott-Armstrong N, Fields S, Roth F, Starita LM, Trapnell C, Villen J, Fowler DM, Queitsch C
Multiplexed Assays of Variant Effect and Automated Patch Clamping Improve KCNH2-LQTS Variant Classification and Cardiac Event Risk Stratification.
O'Neill MJ, Ng CA, Aizawa T, Sala L, Bains S, Winbo A, Ullah R, Shen Q, Tan CY, Kozek K, Vanags LR, Mitchell DW, Shen A, Wada Y, Kashiwa A, Crotti L, Dagradi F, Musu G, Spazzolini C, Neves R, Bos JM, Giudicessi JR, Bledsoe X, Gamazon ER, Lancaster MC, Glazer AM, Knollmann BC, Roden DM, Weile J, Roth F, Salem JE, Earle N, Stiles R, Agee T, Johnson CN, Horie M, Skinner JR, Ackerman MJ, Schwartz PJ, Ohno S, Vandenberg JI, Kroncke BM
Multiplexed Assays of Variant Effect and Automated Patch-clamping Improve KCNH2-LQTS Variant Classification and Cardiac Event Risk Stratification.
O'Neill MJ, Ng CA, Aizawa T, Sala L, Bains S, Winbo A, Ullah R, Shen Q, Tan CY, Kozek K, Vanags LR, Mitchell DW, Shen A, Wada Y, Kashiwa A, Crotti L, Dagradi F, Musu G, Spazzolini C, Neves R, Bos JM, Giudicessi JR, Bledsoe X, Gamazon ER, Lancaster M, Glazer AM, Knollmann BC, Roden DM, Weile J, Roth F, Salem JE, Earle N, Stiles R, Agee T, Johnson CN, Horie M, Skinner J, Ackerman MJ, Schwartz PJ, Ohno S, Vandenberg JI, Kroncke BM
Systematically mapping functional human sequence variation and context-dependent protein interactions
Principal investigators: Roth, Frederick
Keywords: Functional Genomics; Genetic Interaction; Human Sequence Variation; Next-Generation Sequencing; Personal Genomics; Protein Interaction; Sequence Variant Interpretation; Systems Biology
Regenerative biomaterials in vascularized tissue engineering
Principal investigators: Sefton, Michael V
Keywords: Biomaterials; Endothelial Cells; Host Response; Macrophage; Tissue Engineering; Vascularization
From correlation to causation in genomics: identifying mechanisms underlying disease
Principal investigators: Bader, Gary D
Keywords: Bioinformatics; Biological Networks; Biological Pathways; Computational Biology; Disease Mechanisms; Functional Genomics; Protein Domains; Protein Interactions; Proteomics
Discovering gene functions, the pathways they encode, and how these genes and pathways are related to human disease
Principal investigators: Roth, Frederick
Keywords: Dna Sequencing; Gene Functions; Gene Pathways; Genetic Changes; Proteins
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
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