Research
Read how they describe their research on their University of Toronto profile.
Latest papers
Hepatic responses as potential biomarkers of idiosyncratic drug reaction risk.
Toxicological sciences : an official journal of the Society of Toxicology · 2026 · senior author
Relevance of reactive metabolites and covalent binding to drug candidate selection.
Drug metabolism reviews · 2026 · first author
TAK-994 mechanistic investigation into drug-induced liver injury.
Toxicological sciences : an official journal of the Society of Toxicology · 2025
Latest funding
- $688,500
Study of the Innate Immune Response to Drugs that Cause IDRs
CIHR · 2021 · Nominated PI
- $496,295
Immune responses to drugs that cause idiosyncratic liver injury and agranulocytosis
CIHR · 2015 · Nominated PI
- $522,215
Investigation of the Mechanisms of Idiosyncratic Drug Reactions
CIHR · 2012 · Nominated PI
76 publications.
Hepatic responses as potential biomarkers of idiosyncratic drug reaction risk.
Liao J, Lyu X, Yang K, Chen L, Uetrecht J
Relevance of reactive metabolites and covalent binding to drug candidate selection.
Uetrecht J
TAK-994 mechanistic investigation into drug-induced liver injury.
Shinozawa T, Miyamoto K, Baker KS, Faber SC, Flores R, Uetrecht J, von Hehn C, Yukawa T, Tohyama K, Kadali H, von Grotthuss M, Sudo Y, Smith EN, Diogo D, Zhu AZX, Dragan Y, Cebers G, Wagoner MP
The use of PD-1 functional knockout rats to study idiosyncratic adverse reactions to nevirapine.
Cho T, Hayes A, Henderson JT, Uetrecht J
The role of corticosterone in nevirapine-induced idiosyncratic drug-induced liver injury.
Jee A, Sernoskie SC, Uetrecht J
The development and characterization of a CRISPR/Cas9-mediated PD-1 functional knockout rat as a tool to study idiosyncratic drug reactions.
Cho T, Wierk A, Gertsenstein M, Rodgers CE, Uetrecht J, Henderson JT
Potential Involvement of Sulfotransferase in the Mechanism of Lamotrigine-induced Skin Rash.
Cao Y, Bairam A, Liu MC, Uetrecht J
The Role of Myeloperoxidase in Clozapine-Induced Inflammation: A Mechanistic Update for Idiosyncratic Drug-Induced Agranulocytosis.
Sernoskie SC, Jee A, Uetrecht J
Idiosyncratic Drug Reactions: A 35-Year Chemical Research in Toxicology Perspective.
Uetrecht J
Sulfation of 12-hydroxy-nevirapine by human SULTs and the effects of genetic polymorphisms of SULT1A1 and SULT2A1.
Kurogi K, Cao Y, Segawa K, Sakakibara Y, Suiko M, Uetrecht J, Liu MC
Study of the Innate Immune Response to Drugs that Cause IDRs
Principal investigators: Uetrecht, Jack P
Keywords: Adverse Drug Reactions, Immune-Mediated
Immune responses to drugs that cause idiosyncratic liver injury and agranulocytosis
Principal investigators: Uetrecht, Jack P
Keywords: Adverse Drug Reactions; Drug Metabolism; Immune Tolerance; Immune-Mediated
Investigation of the Mechanisms of Idiosyncratic Drug Reactions
Principal investigators: Uetrecht, Jack P
Keywords: Animal Models; Drug Metabolism; Idiosyncratic Drug Reactions; Immunotoxicity
Macrophage Activation by Drugs Leading to Autoimmunity
Principal investigators: Uetrecht, Jack P
Keywords: Adverse Drug Reactions; Autoimmunity; Drug Safety
Arylhydroxylamine esters: formation and reactions in chemical and biological systems
Principal investigators: McClelland, Robert
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
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Profile data last refreshed on September 25, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.